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| 1 | Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-KB inflammatory signaling pathway显示文摘Xyloketal B (Xyl-B ) 是从红树属植物真菌 Xylaria sp 孤立的新奇海洋的混合物。我们以前证明有 Xyl-B 的那个预告的处理施加了 neuroprotective 效果并且在新生的老鼠稀释了 hypoxic-ischemic 大脑损害。在现在的学习,我们调查了预告的处理的 neuroprotective 效果并且与在用短暂中间的成年老鼠的 Xyl-B 处理以后服的动脉吸藏(tMCAO ) 模型,并且探索了内在的机制。成年男 C57 老鼠受到 tMCAO 外科。为预告的处理, Xyl-B 经由多重注射被给(12.5, 25,和 50 mg ?@ | Ni PAN Liu-yi LU Mei LI Guo-hao WANG Fang-yu n SUN Hong-shuo SUN Xue-jun WEN Jian-ding CHENG Jian- wen CHEN Ji-yan PANG Jie LIU Yong-yuan GUAN Li-yan ZHAO Wen-liang CHEN Guan-lei WANG | 2017 | Acta Pharmacologica Sinica2017，38，9： | 24 |
| 2 | Neuroprotective effects of INT-777 against Aβ1-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice显示文摘OBJECTIVE To investigate the neuroprotective effects of TGR5 agonist INT-777 in the Aβ_(1-42)-treated mouse model of acute neurotoxicity.METHODS Cognitive impairment was induced by single intracerebroventricular injection of aggregated Aβ_(1-42)(410 pmol per mouse;5 μL)into the mouse brain in normal ICR mice.After3 d,INT-777(0.75,1.5 or 3.0 μg per mouse) was infused into the same site.Another 3 d later,the cognition function was evaluated by Morris water maze(MWM),novel objective recognition(NOR),and Y maze tests.Furthermore,the levels of TGR5,TNF-α,IL-1β,IL-6,NF-κB p65,Iba1,caspase 3,Bcl-2,Bax,PSD95,and synaptophysin in the hippocampus and frontal cortex were detected using Western blotting.Microglia activation in the hippocampal CA1,CA3 and DG regions and frontal cortex were detected by immunohistochemistry.TUNEL staining was used to detect the apoptotic cells.The number of spines in the hippocampal CA1,CA3 and DG regions and frontal cortex was detected by GolgiCox staining.RESULTS INT-777(1.5 or 3.0 μg per mouse) significantly ameliorated memory impairment in the Aβ_(1-42)-treated mice,evidenced by increased the time spent in the target quadrant(P<0.05),and the number of target crossings(P<0.05) in the MWM test,increased the discrimination index in the NOR test(P<0.05),and increased the number of correct choices(P<0.05,P<0.01) and decreased the latency(P<0.05) to enter the shock-free compartment in the Y-maze test.Importantly,this treatment reversed Aβ_(1-42)-induced TGR5 down-regulation(P<0.05,P<0.01),suppressed the increase of nuclear NF-κB p65(P<0.05,P<0.01) and mitigated neuroinflammation,evidenced by lower proinflammatory cytokines such as TNF-α(P<0.05),IL-1β(P<0.05),IL-6(P<0.05,P<0.01),and less Iba1-positive cells in the hippocampal CA1,CA3 and DG regions and frontal cortex(P<0.05,P<0.01) as well as the protein level of Iba1.INT-777(1.5 or3.0 μg per mouse) also pronouncedly suppressed apoptosis through the reduction of TUNEL-positive cells(P<0.05,P<0.01),decreased activation of caspase 3(P<0.05),increased ratio of Bcl-2/Bax(P<0.05,P<0.01),and ameliorated synaptic dysfunction via promoting dendritic spines generation(P<0.05,P<0.01) with the upregulation of PSD95(P<0.05) and synaptophysin proteins(P<0.05).CONCLUSION INT-777 has potent neuroprotective effects against Aβ_(1-42)-induced neurotoxicity,which suggests that the activation of TGR5 could be a novel and promising strategy for the treatment of AD. | WU Xian LYU Yang-ge DU Yi-feng CHEN Fang Miranda N REED HU Mei Vishnu SUPPIRAMANIAM TANG Su-su HONG Hao | 2018 | 中国药理学与毒理学杂志2018，32，9： | 6 |
| 3 | Chaos behavior of crude copper composition time series from the copper convertor and the predicable time scale显示文摘 | WANG Y N MEI Ch | 2006 | Nonlinear Analysis:Real World Applications2006，7，4： | 1 |
| 4 | Testing the importance of the explanatory variables in a mixed geographically weighted regression model显示文摘 | Mei C Wang N Zhang W | 2006 | Environment and Planning A2006，38，： | 1 |
| 5 | A New Fluorescent Probe of Rhodamine B Derivative for the Detection of Copper Ion显示文摘 | Mei L Xiang Y Li N | 2007 | Talanta2007，72，5： | 1 |
| 6 | 3-D mapping of regional soil hydraulic characteristics through establishment of pedo-transter functions显示文摘 | Mei D Hui H Christoph N | 2012 | Disaster Advances2012，5，4： | 1 |
| 7 | Effect of hot-isostatic-press- ing parameters on the microstructure and properties of powder Ti- 6A1- 4V hot- isostatically- pressed samples显示文摘 | ZHANG K MEI J WAIN N | 2010 | Metallurgical and Materials Transactions: A2010，41，4： | 1 |
| 8 | Genetic mapping and QTL analysis of fiber related traits 显示文摘 | MEI M Syed N H Gao W | 2004 | Theor Appl Genet2004，108，： | 1 |
| 9 | Bone marrow mesenchymal stem cells can differentiate into type Ⅱ alveolar epithelial cells in vitro显示文摘 | Ma N Gai H Mei J | | 0，，12： | 1 |
| 10 | Occupatinal head injury and subsequent glioma显示文摘 | Magnavita N Placentino RA Mei D | 2003 | Neurol Sci2003，24，1： | 1 |
| 11 | Sensitive and selective spectrofluorimetric determination of chromium(Ⅵ)in water by fluorescenceenhancement显示文摘 | Xiang Y Mei L Li N | 2007 | Analytica Chimica Acta2007，581，： | 1 |
| 12 | Free convection in a liquid-encapsulated molten semiconductor in a vertical magnetic field 显示文摘 | Yang Mei Ma N | 2005 | International Journal of Heat and Mass Transfer2005，48，1920： | 1 |
| 13 | Modified (NHC) Pd (allyl) Cl ( NHC = N-heterocyclic carbene) complexes for room-temperature Suzuki-Miyaura and Buchwald-Hartwig reactions显示文摘 | Marion N Navarro O Mei J G | 2006 | J Am Chem Soc2006，12，12： | 1 |
| 14 | Risk factors for liver disease among adults of Mexican descent in the United States and Mexico显示文摘AIM To compare the prevalence of chronic liver disease(CLD) risk factors in a representative sample of MexicanAmericans born in the United States(US) or Mexico, to a sample of adults in Mexico.METHODS Data for Mexican-Americans in the US were obtained from the 1999-2014 National Health and Nutrition Examination Survey(NHANES), which includes persons of Mexican origin living in the US(n = 4274). The NHANES sample was restricted to Mexican-American participants who were 20 years and older, born in the US or Mexico, not pregnant or breastfeeding, and with medical insurance.The data in Mexico were obtained from the 2004-2013 Health Worker Cohort Study in Cuernavaca, Mexico(n =9485). The following known risk factors for liver disease/cancer were evaluated: elevated aminotransferase levels(elevated alanine aminotransferase was defined as > 40 IU/L for males and females; elevated aspartate aminotransferase was defined as > 40 IU/L for males and females), infection with hepatitis B or hepatitis C,metabolic syndrome, high total cholesterol, diabetes,obesity, abdominal obesity, and heavy alcohol use. The main independent variables for this study classified individuals by country of residence(i.e., Mexico vs the US) and place of birth(i.e., US-born vs Mexico-born).Regression analyses were used to investigate CLD risk factors.RESULTS After adjusting for socio-demographic characteristics,Mexican-American males were more likely to be obese,diabetic, heavy/binge drinkers or have abdominal obesity than males in Mexico. The adjusted multivariate results for females also indicate that Mexican-American females were significantly more likely to be obese, diabetic, be heavy/binge drinkers or have abdominal obesity than Mexican females. The prevalence ratios and prevalence differences mirror the multivariate analysis findings for the aforementioned risk factors, showing a greater risk among US-born as compared to Mexico-born MexicanAmericans. CONCLUSION In this study, Mexican-Americans in the US had more risk factors for CLD than their counterparts in Mexico.These findings can be used to design and implement more effective health promotion policies and programs to address the specific factors that put Mexicans at higher risk of developing CLD in both countries. | Yvonne N Flores Zuo-Feng Zhang Roshan Bastani Mei Leng Catherine M Crespi Paula Ramírez-Palacios Heather Stevens Jorge Salmerón | 2018 | World Journal of Gastroenterology2018，24，37： | 1 |
| 15 | A new cytotoxic pregnanone from Calotropis gigantea显示文摘 | Wang Z N Wang M Y Mei W L | 2008 | Molecules2008，13，12： | 1 |
| 16 | Learning group-based dictionariesfor discriminative image representation 显示文摘 | Lei H Mei K Zheng N | 2014 | Pattern Recognition2014，47，2： | 1 |
| 17 | Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation显示文摘 | Pidkovka N Rao R Mei S | 2013 | J Biol Chem2013，288，7： | 1 |
| 18 | Endogenous salicylic acid protects rice plants from oxidative damage caused by aging as well as biotic and abiotic stress显示文摘 | Yang Y N Qi M Mei C S | 2004 | The Plant Journal2004，40，： | 1 |
| 19 | A New Colorimetric and Fluorescent Ratiometric Sensor for Hg2 ~ Based on 4-Pyren- 1-yl-pyrimidine 显示文摘 | Weng J N Mei Q B Ling Q D | 2012 | Tetrahedron2012，68，1： | 1 |
| 20 | Biocompatibility of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)modified by silk fibroin显示文摘 | Mei N Zhou P Pan LF | | 0，，： | 1 |
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