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| 1 | Surveillance for hepatocellular carcinoma in chronic liver disease:Evidence and controversies显示文摘Primary liver cancer is the sixth most common cancer in the world and the third cause of cancer-related death.Hepatocellular carcinoma(HCC)represents more than90%of primary liver cancers and generally occurs in patients with underlying chronic liver disease such as viral hepatitis,hemochromatosis,primary biliary cirrhosis and non-alcoholic steatohepatitis.Especially cirrhotic patients are at risk of HCC and regular surveillance could enable early detection and therapy,with potentially improved outcome.We here summarize existing evidence for surveillance including ultrasound,other radiological modalities and various serum biomarkers,and current international guideline recommendations for surveillance.Ultrasound andα-fetoprotein(alone or in combination)are most frequently used for surveillance,but their sensitivities and specificities are still far from perfect,and evidence for surveillance remains weak and controversial.Various other potential surveillance tools have been tested,including serum markers as des-carboxyprothrombin,lectin-boundα-fetoprotein,and(most recently)circulating TIE2-expressing monocytes,and radiological investigations such as computed tomographyscan or magnetic resonance imaging-scan.Although early results appear promising,these tools have generally been tested in diagnostic rather than surveillance setting,and in most cases,no detailed information is available on their cost-effectiveness.For the near future,it remains important to define those patients with highest risk of HCC and most benefit from surveillance,and to restrict surveillance to these categories. | Suzanne van Meer Robert A de Man Peter D Siersema Karel J van Erpecum | 2013 | World Journal of Gastroenterology2013，19，40： | 10 |
| 2 | The relation between morphology and hydrotreating activity for supported MoS2 particles 显示文摘 | HENSEN E J M KOOYMAN P J Van der MEER Y Van der KRAAN A M de BEER V H J Van VEEN J A R Van SANTEN R A | 2001 | J Catal2001，199，2： | 1 |
| 3 | SAPE: A program for semi-automatic parameter extraction for strain analysis 显示文摘 | Mulehrone K F Meere P A Choudhury K R | 2005 | Journa| of Structural Geology2005，27，11： | 1 |
| 4 | Cytomegalovirus as a cause of anterior uveitis in immunocompetent patients显示文摘 | van Boxtel LA van der Lelij A van der Meer J | 2007 | Ophthalmology2007，114，： | 1 |
| 5 | Advanced hybrid transient stability and EMTsimulation for VSC-HVDC Systems 显示文摘 | VAN DER MEER A A GIBESCU M VAN DER MEIJDEN M A M M | 2015 | IEEE Transactions on Power Delivery2015，30，3： | 1 |
| 6 | The impact of radiation therapy on quality of life in patients with cancer显示文摘 | Liu L Meers K Capurso A | 1998 | Cancer Pract1998，6，： | 1 |
| 7 | Rapamycin and MPA, but not CsA, impair human NK cell cytotoxicity due to differential effects on NK cell phenotype显示文摘 | Eissens DN Van Der Meer A Van Cranenbroek B | 2010 | AmJ Transplant2010，10，9： | 1 |
| 8 | Dietary cheese whey protein protects rats against mild dextran sulfate sodium-induced colitis:role ofmucin and microbiota显示文摘 | Sprong R C Schonewille A J van der Meer R | 2010 | J Dairy Sci2010，93，4： | 1 |
| 9 | Long-term sustainability of metal immobilization by soil amendments:Cy clonie ashes versus lime addition显示文摘 | RUTENS A ADRIAENSEN K MEERS E | 2010 | Environment Pollution2010，158，14： | 1 |
| 10 | Risk factors for progression of atheroscleresis measml at multiple sites in the arterial tree: the Rotterdam Study 显示文摘 | Van der Meer IM Iglesias del Sol A Hak AE | 2003 | Stroke2003，34，： | 1 |
| 11 | Donor and recipient HLA/KIR genotypes do not predict liver transplantation outcome 显示文摘 | Moroso V van der Meer A Tilanus HW | 2011 | Transpl Int2011，24，9： | 1 |
| 12 | Multi- and hyperspectral geologic remote sensing: A review显示文摘 | van der Meer F D van der Werff H M A van Ruitenbeek F J A | 2012 | International Journal of Applied Earth Observation and Geoinformation2012，14，1： | 1 |
| 13 | Polyphosphate accumulation in the senescing mushroom Agaricus bisporus显示文摘 | Braaksma A Meer P V Schaap D J | 1996 | Post-harvest Biology and Technology1996，8，： | 1 |
| 14 | KIR gene and KIR ligand analysis to predict graft rejection after renal transplantation显示文摘 | Kreijveld E Van der Meer A Tijssen H J | 2007 | Transplantation2007，84，8： | 1 |
| 15 | Comparison of EDTA and EDDS as potential soil amendments for enhanced phytoextraction of heavy metal显示文摘 | Meers E Ruttens A Hopgood M J | 2005 | Chemosphere2005，58，： | 1 |
| 16 | Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke:the Rotterdam Study显示文摘 | Oei HH van der Meer IM Hofman A | 2005 | Circulation2005，111，： | 1 |
| 17 | Comparison of EDTA and EDDS aspotential soil amendments forenhanced phytoextraction of heavy metals显示文摘 | Meers E Ruttens A Hopgood M J | 2005 | Chemosphere2005，58，： | 1 |
| 18 | In vivo evidence for a role of toll-like receptor 4 in the development of intimal lesions显示文摘 | Vink A Schoneveld AH van der Meer JJ | 2002 | Circulation2002，106，15： | 1 |
| 19 | Finite strain estimation using the mean radial length of elliptical objects with bo-otstrap confidence intervals 显示文摘 | Mulehrone K F Meere P A | 2003 | Journal of Structural Geology2003，25，4： | 1 |
| 20 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
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