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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Microbial biomass estimated by phospholipids phosphate in soil with diverse microbial communities显示文摘 | Hiu T C J McPherson E F Harris J A | 1993 | Soil Biochem1993，25，： | 1 |
| 3 | Alluvial-Fans and TheirNatural Distinction from Rivers Based on Morpholo-gy, Hydraulic Iocesses, Sedimentary Processes,and Facies Assemblages 显示文摘 | Blair T C Mcpherson J G | 1994 | Journal of SedimentaryResearch1994，64，： | 1 |
| 4 | Prevention of protein adsorption by tethered poly(ethylene oxide) layers: experiments and single-chain mean-field analysis显示文摘 | MCPHERSON T K/DANE A SZLEIFER I PARK K | 1998 | Langmuir1998，14，1： | 1 |
| 5 | Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management显示文摘 | McPherson S Hardy T Henderson E | 2015 | J Hepatol2015，62，5： | 1 |
| 6 | Global data assimilation experiments with scatterometer winds from SEASAT-A显示文摘 | Yu T W Mcpherson R D | 1984 | Monthly Weather Review1984，112，1： | 1 |
| 7 | Real-time, universal screening for acute HIV infection in a routine HIV counseling and testing population 显示文摘 | Pilcher CD Mcpherson J T Leone PA | 2002 | JAMA2002，288，： | 1 |
| 8 | Prevention of protein adsorption by tethered poly(ethylene oxide) layers:experiments and single-chain mean-field analysis显示文摘 | McPherson T Kidane A Szleifer I | 1998 | Langmuir1998，14，： | 1 |
| 9 | Modelling the atmospheric deposition and stormwater washoff of nitrogen compounds 显示文摘 | Burian S J Streit G E McPherson T N | 2001 | Environ Modell Software2001，16，5： | 1 |
| 10 | A review of tree root conflicts with sidewalks, curbs, and roads 显示文摘 | Randrup T B McPherson E G Costello L R | 2001 | Urban Ecosystems2001，5，3： | 1 |
| 11 | Microbial biomass estimated by phospholipid phosphate in soils with diverse microbial communities显示文摘 | HILL T C J MCPHERSON E F HARRIS J A | 1993 | Soil Biol Biochem1993，25，12： | 1 |
| 12 | Grain-size and textural classifical of coarse sedimentary particles 显示文摘 | Blair T C McPherson J G | 1999 | Journal of Sedimentary Research1999，69，1： | 1 |
| 13 | Structural characteriza- tion of plasma sprayed hydroxyapatite coatings 显示文摘 | Mcpherson R Gane N Bastow T | 1995 | Journal of Materials Science-Materials in Medicine1995，6，6： | 1 |
| 14 | Scavenger Receptor Class B Type I Localizes to A Late Endosomal Compartment显示文摘 | Ahras M Nainq T Mcpherson R | 2008 | J Lipid Res(S0022-2275)2008，49，7： | 1 |
| 15 | Modeling the atmospheric deposition and stormwater washoff of nitrogen compounds 显示文摘 | Burian S J Streit G E McPherson T N | 2001 | Environ Modelling Software2001，16，5： | 1 |
| 16 | Evaluation of transgenic soybean exhibiting high expression of a synthetic Bacillus thuringiensis crylA transgene for suppressing lepidopteran population densities and crop injury显示文摘 | McPherson R M MacRae T C | 2009 | Journal of Economic Entomology2009，102，4： | 1 |
| 17 | The efficacy and safety of weekly vinorelbine in relapsed malignant pleural mesothelioma显示文摘 | STEBBING J POWLES T MCPHERSON K | 2009 | Lung Cancer2009，63，1： | 1 |
| 18 | Modeling the atmospheric deposition and stormwater washoff of nitrogen compounds 显示文摘 | Burian S J Streit G E McPherson T N | 2001 | Environmental Modelling & Software2001，16，5： | 1 |
| 19 | Submerged arc welding of stainless steel and the challenge from the laser welding process显示文摘 | Mcpherson N A Chi K Baker T N | 2003 | Journalof Materials Processing Technology2003，134，： | 1 |
| 20 | Global data assimilation experiments with scatterometer winds from SEASAT-A显示文摘 | YU T W MCPHERSON R D | 1984 | Mon Wea Ree1984，112，： | 1 |
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