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368篇 您的检索式：作者名="Mclean G"

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	题名	作者	年代	出处	被引量
1	Molecular isoform distribution and glycosylation of acetycholinesterase are altered in brain and cerebrospinal fluid of patients with Alzheimer's disease显示文摘	Saez-Valero J Sberna G Mclean A	1999	Neurochem1999，72，4：	2
2	Embryo-mediated genome editing for accelerated genetic improvement of livestock显示文摘Selecting beneficial DNA variants is the main goal of animal breeding.However,this process is inherently inefficient because each animal only carries a fraction of all desirable variants.Genome editing technology with its ability to directly introduce beneficial sequence variants offers new opportunities to modernize animal breeding by overcoming this biological limitation and accelerating genetic gains.To realize rapid genetic gain,precise edits need to be introduced into genomicallyselected embryos,which minimizes the genetic lag.However,embryo-mediated precision editing by homology-directed repair(HDR)mechanisms is currently an inefficient process that often produces mosaic embryos and greatly limits the numbers of available edited embryos.This review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated accelerated breeding scheme that overcomes the present efficiency limitations of HDR editing in bovine embryos.It integrates embryo-based genomic selection with precise multi-editing and uses embryonic cloning with elite edited blastomeres or embryonic pluripotent stem cells to resolve mosaicism,enable multiplex editing and multiply rare elite genotypes.Such a breeding strategy would enable a more targeted,accelerated approach for livestock improvement that allows stacking of beneficial variants,even including novel traits from outside the breeding population,in the most recent elite genetic background,essentially within a single generation.	Zachariah MCLEAN Björn OBACK Götz LAIBLE	2020	Frontiers of Agricultural Science and Engineering2020，7，2：	2
3	P450 BM3:the very model of a modern flavocytochrome 显示文摘	MUNRO A W LEYS D G MCLEAN K J	2002	Trends Biochem Sci2002，27，5：	1
4	Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘	Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G	1998	Nature1998，393，：	1
5	Quaternary ammonium compounds in the Capparaceae显示文摘	Mclean W F H Blunden G Jewers K	1996	Biochem Syst Ecol1996，24，5：	1
6	Pilot-scale Casting of Single-crystal Copper Wires by the Ohno Continuous Casting Process显示文摘	Soda H McLean A Wang Z and Motoyasu G	1995	Journal of Materials Science1995，，30：	1
7	Line-based correction of radial lens distortion显示文摘	PRESCOTT B MCLEAN G	1997	Graphical Models and Image Processing1997，59，1：	1
8	Cathodoluminescence and trace element zoning in quartz phenocrysts and xenocrysts 显示文摘	Watt G R Wright P Galloway S McLean C	1997	Geochim Cosr nochim1997，61，：	1
9	The characteristics of single crystal bismuth wires produced by the Ohno continuous casting process 显示文摘	Motoyasu G Kadowaki H Soda H McLean A	1999	Journal of materials science1999，，34：	1
10	Granular cell tumours of the gastrointestinal tract:expression of nestin and clinicopathological evaluation of 11 patients显示文摘	Parfitt J R McLean C A Joseph M G	2006	Histopathology2006，48，：	1
11	Effect of co-ingestion of fat on the metabolic responses to slowly and rapidly absorbed carbohydrates 显示文摘	Collier G Mclean A O'Dea K	1984	Diabetologia1984，26，1：	1
12	Mapping QTLs for resistance to the cyst nematode Globodera palli da derived from the wild potato species Solanum vernei显示文摘	Bryan G Mclean K Bradshaw E	2002	TAG2002，105，：	1
13	Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation显示文摘	Noseda M McLean G Niessen K		0，，07：	1
14	Studies of the Solid-liquid Interface Location during Heated Mould Continuous Casting of Metals and Alloys显示文摘	Soda H McLean A and Motoyasu G	2005	International Journal of Cast Metals Research2005，18，3：	1
15	Ligand regulation of green fluorescent protein-tagged forms of the human bota(1 ) - and born(2) - adrenoceptors;comparisons with is the unmodified receptors 显示文摘	Mclean AJ Milligan G	2000	Br J Pharmacol2000，130，8：	1
16	Nonlinear absorption study of a C60-toluene solution显示文摘	McLean D G Sutherland R L Brant M C	1993	Opt Lett1993，18，11：	1
17	Development and Initial Validation of an Instrument Measuring Coaching Skill显示文摘	McLean G N Yang B & Kuo M C	2005	Human Resource Development Quarterly2005，16，2：	1
18	Continuously cast Cu-Al-Ni shape memory wires with a unidirectional morphology显示文摘	MOTOYASU G KANEKO M SODA H MCLEAN A	2001	Metallurgical and Materials Transactions A2001，32，3：	1
19	In vitro neurotoxicity of artemlsinin derivatives 显示文摘	McLEAN W G WARD S A	1998	Med Trop(Mars)1998，58，3：	1
20	Effect of porosity and surface hydrophilicity on migration of epithelial tissue over synthetic polymer显示文摘	Steele JG Johnson G McLean KM	2000	J Biomed Mater Res2000，50，：	1

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