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| 1 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 2 | Mechanical thrombectomy with the S olitaire AB device in large intracerebral artery occlusions显示文摘 | John J McCabe Timothy J Phillips Con Phatouros Tejinder Singh David Blacker Graeme J Hankey William McAuliffe | 2012 | Journal of Medical Imaging and Radiation Oncology2012，，2： | 2 |
| 3 | Translocation of cytochrome c from the mitochondria to the cytosol occurs during heat - induced programmed cell death in cucumber plants显示文摘 | Balk J Leaver C J McCabe PF | 1999 | FEBS Lett1999，463，： | 1 |
| 4 | A matdx metalloproteinase gene is expressed at the boundary of senescence and programmed cell death in cucumber显示文摘 | DELORME VGR MCCABE PF KIM D J | 2000 | Plant Physiol2000，123，： | 1 |
| 5 | Predicting facies architecture through sequence stratigraphy-an example from the Kaiparowits Plateau, Utah 显示文摘 | Shanley K W McCabe P J | 1991 | Geology1991，19，3： | 1 |
| 6 | Absorption distribution etelimination de I'extrait marque de Ginkgo biloba chezle rat显示文摘 | Moreau JP Eck J McCabe J | 1996 | Presse Med1996，15，： | 1 |
| 7 | Expression of pituitarytumor transforming gene in colorectal tumors 显示文摘 | Heaney AP Singson R McCabe C J | 2000 | Lancet2000，355，： | 1 |
| 8 | Relationships between identity and self-representations during adolescence 显示文摘 | Makros J McCabe M P | 2001 | Journal of youth and adolescence2001，30，5： | 1 |
| 9 | Differences in topographic characteristics computed from 100-and 1000-m resolution digital elevation model data 显示文摘 | David M W Gregory J McCabe | 2000 | Hydrological Processes2000，14，： | 1 |
| 10 | Acceleration of tibia and distal radius fracture healing in patients who smoke显示文摘 | Cook S D Ryaby J P McCabe J | 1997 | Clin Orthop Relat Res1997，337，： | 1 |
| 11 | Perspectives on the sequence stratigraphy of continental strata 显示文摘 | Shanley K W McCabe P J | 1994 | AAPG1994，78，4： | 1 |
| 12 | Improved method for the estimation of hydroxyl free radical levels in vivo based on liquid chromatograph with electrochemical detraction显示文摘 | MCCABE D R MAHER T J ACWORTH I N | 1997 | J Chromatogr B1997，691，： | 1 |
| 13 | A fully human mono- clonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL显示文摘 | Kostenuik P J Nguyen H Q McCabe J | 2009 | Bone Miner Res2009，24，2： | 1 |
| 14 | Evaluating the use of goodness of fit measures in hydropic and hydro-climatic model validation 显示文摘 | LEGATES D R MCCABE G J | 1999 | Water Re- sources1999，35，1： | 1 |
| 15 | Long-term outcome after angiop~asty and stenting for symptomatic vertebral artery stenosis compared with medical treatment in the Carotid And Vertebral Artery Transluminal Angioplasty Study ( CAVATAS ): a randomized triM显示文摘 | Coward LJ McCabe DJ Ederle J | 2007 | Stroke2007，38，5： | 1 |
| 16 | Trust,Reciprocity and Social History显示文摘 | Berg J Dickhaut J McCabe K | | 0，，10： | 1 |
| 17 | A study of frictional forces between brackets and archwires显示文摘 | Downing A McCabe J Gordon P | 1994 | Br J Orthod1994，21，4： | 1 |
| 18 | School cli- mate : Research, policy, practice, and teacher education 显示文摘 | Cohen J Mccabe E M Michelli N M | 2009 | Teachers College Record2009，111，1： | 1 |
| 19 | Cancer DNA methylation: molecular mechanisms and clinical implications显示文摘 | McCabe M T Brandes J C Vertino P M | 2009 | Clin Cancer Res2009，15，12： | 1 |
| 20 | Degree of residual stenosis in the culprit coronary artery after thmmbolytic administration( thrembolysis in myocardial infarction trials显示文摘 | Llevadot J Giugliano RP McCabe CH | 2000 | Am J Cardiol2000，85，12： | 1 |
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