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	题名	作者	年代	出处	被引量
1	Molecular targets in the treatment of alcoholic hepatitis显示文摘Alcohol related costs to health and society are high. One of the most serious complications of alcohol misuse to the individual is the development of alcoholic hepatitis (AH), a clinical syndrome of jaundice and progressive inflammatory liver injury in patients with a history of recent heavy alcohol use. It has a poor outcome and few existing successful therapies. The use of glucocorticoids in patients with severe AH is still controversial and there remains a group of patients with glucocorticoid-resistant disease. However, as our understanding of the pathogenesis of the condition improves there are opportunities to develop new targeted therapies with specific actions to control liver inflammation without having a detrimental effect on the immune system as a whole. In this article we review the molecular mechanisms of AH concentrating on the activation of the innate and adaptive immune response. We consider existing treatments including glucocorticoids, anti-tumor necrosis factor therapy and pentoxifylline and their limitations. Using our knowledge of the disease pathogenesis we discuss possible novel therapeutic approaches. New targets include pro-inflammatory cytokines such as interleukin (IL)-17, chemokines and their receptors (for example IL-8, CXCL9 and CXCR3) and augmentation of anti-inflam- matory molecules such as IL-10 and IL-22. And there is also future potential to consider combination therapy to selectively modulate the immune response and gain control of disease.	Ashwin D Dhanda Richard WL Lee Peter L Collins C Anne McCune	2012	World Journal of Gastroenterology2012，18，39：	9
2	Is liver biopsy necessary in the management of alcoholic hepatitis?显示文摘Acute alcoholic hepatitis(AAH)is characterised by deep jaundice in patients with a history of heavy alcohol use,which can progress to liver failure.A clinical diagnosis of AAH can be challenging to make in patients without a clear alcohol history or in the presence of risk factors for other causes of acute liver failure.Other causes of acute on chronic liver failure such as sepsis or variceal haemorrhage should be considered.Liver biopsy remains the only reliable method to make an accurate diagnosis.However,there is controversy surrounding the use of liver biopsy in patients with AAH because of the risks of performing a percutaneous biopsy and limitations in access to transjugular biopsy.We review the existing literature and find there are few studies directly comparing clinical and histological diagnosis of AAH.In the small number of studies that have been conducted the correlation between a clinical and histological diagnosis of AAH is poor.Due to this lack of agreement together with difficulties in accessing transjugular liver biopsy outside tertiary referral centres and research institutions,we cannot advocate universal biopsy for AAH but there remains a definite role for liver biopsy where there is clinical diagnostic doubt or dual pathology.Italso adds value in a clinical trial context to ensure a homogeneous trial population and to further our understanding of the disease pathology.Further prospective studies are required to determine whether non-invasive markers can be used to accurately diagnose AAH.	Ashwin D Dhanda Peter L Collins C Anne McCune	2013	World Journal of Gastroenterology2013，19，44：	4
3	Renal cell carcinoma treated by vaccines for active specific immunotherapy: correlation of survival with skin testing by autologous tumor cell显示文摘	McCune C S O'Donnell R W Marquis D M	1990	Cancer Immunol Immunother1990，32，：	1
4	Regulation of pineal alpha1B -adrenergic receptor mRNA: day/night rhythm and beta- adrenergic receptor/cyclic AMP control 显示文摘	Coon SL McCune SK Sugden D	1997	Mol Pharmacol1997，51，4：	1
5	hnmunosuppressive drug therapy of systemic lupus erythematosus 显示文摘	Fox D A McCune W J	1994	Rheum Dis Clin North Am1994，20，1：	1
6	Th17 and regulatory T cells: implications for AIDS pathogenesis 显示文摘	Kanwar B Favre D McCune JM	2010	Curt Opin HIV AIDS2010，5，2：	1
7	The charac- terization of friction stir welding process effects on stiffened panel buckling performance 显示文摘	Murphy A McCune W Quinn D	2007	Thin- Walled Structures2007，45，3：	1
8	Thl7 and regulatory T cells: im- plications for AIDS pathogenesis显示文摘	Kanwar B Favre D McCune J M	2010	Curr Opin HIV AIDS2010，5，2：	1
9	Th17 and regulatory T cells:implications for AIDS pathogenesis显示文摘	Kanwar B Favre D McCune JM		0，，02：	1
10	Theory of blade design for large defleteions显示文摘	JAPISKE D BAINES W R MCCUNE J E	1984	Journal of Engineering for Gas Turbines and Power1984，，106：	1
11	The characterisation of friction stir welding process effects on stiffened panel buckling per- formanee显示文摘	MURPHY A MCCUNE W QUINN D	2007	Thin-Walled Structures2007，45，3：	1
12	Equations for potential annual direct incident radiation and heat load 显示文摘	McCune B Keon D	2002	Journal of Vegetation Science2002，13，：	1
13	Th17 and regulatory T cells ~ implications for AIDS pathogenesis显示文摘	KanwarB Favre D McCune JM	2010	Curr Opin HIV AIDS2010，5，：	1
14	Kinetic spray coatings显示文摘	VAN STEENKISTE T H SMITH J R TEETS R E MOLESKI J J GORKIEWICZ D W TISON R P MARANTZ D R KOWALSKY K A RIGGS W L ZAJCHOWSKI P H PILSNER B MCCUNE R C BARNETT K J	1999	Surf Coat Technol1999，111，1：	1
15	The characterization of friction stir welding process effects on stiffened panel buckling performance显示文摘	MURPHY A MCCUNE W QUINN D	2007	Thin-walled Structures2007，45，：	1
16	Aberrant phenotype and func-tion of myeloid dendritic cells in systemic lupus erythematosus显示文摘	Ding D Mehta H McCune W J	2006	Immunol2006，177，9：	1
17	The accumulation of fluorine by plants显示文摘	JACOBSON J S WEINSTEIN L H MCCUNE D C	1966	Journal of the Air Pollution Control Association1966，16，8：	1
18	Granulocyte colony stimulating factor use in cancer patients显示文摘	BAKER J MCCUNE J S HARVEY R D 3RD	2000	Ann Pharmacother2000，34，78：	1
19	Inhibition of suppressor T lymphocytes(Ts) by cimetidine显示文摘	Sahasrabudhe D M McCune C S O'Donnell R W	1987	J Immunol1987，138，9：	1
20	Differences in the cellular localization and agonist-mediated internalization properties of the alpha( 1 ) -adrenoceptor subtypes 显示文摘	Chalothorn D McCune DF Edelmann SE	2002	Mol Pharmacol2002，61，5：	1

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