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| 1 | Patterns of cancer recurrence in localized resected hepatocellular carcinoma显示文摘BACKGROUND:Tumor resection in non-metastatic hepatocellular carcinoma(HCC)patients with adequate liver reserve offers a potential cure,but has a high 5-year recurrence rate.We analyzed the patterns of cancer relapse after partial hepatectomy to guide post-operative management.METHODS:A total of 144 HCC patients(1996-2011)after partial hepatectomy were reviewed.Statistical correlations were determined using univariate and partition analyses.RESULTS:A median follow-up of 20 months showed recurrence in 71(49%)patients,and the median time to recurrence was 11.9 months.Vascular invasion(P<0.01)and number of lesions(P<0.01)predicted for recurrence.Histologic grade was not correlated with recurrence.Twenty-two(31%)patients developed both surgical margin(SM)and concurrent intrahepatic recurrences,and 28(40%)had non-SM intrahepatic recurrences with no other signs of recurrence.On partition analysis,the risk of marginal recurrence in patients with SM<1 mm and SM≥1 mm was 35%and 13.5%respectively.Approximately 57%of patients with intrahepatic recurrence had recurrence≤2.5 cm from SM.CONCLUSIONS:Intrahepatic recurrence after partial hepatectomy is common and is significantly associated with vascular invasion and tumor stage.About 57%of patients with intrahepatic relapse had a recurrence close(≤2.5 cm)to the SM.Additionally,patients with SM<1 mm have a higher recurrence rate and may benefit from adjuvant local therapy. | Aryavarta MS Kumar Elisha T Fredman Christopher Coppa Galal El-Gazzaz Federico N Aucejo May Abdel-Wahab | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，3： | 7 |
| 2 | Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c显示文摘AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA. | Tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna | 2018 | World Journal of Hepatology2018，10，9： | 4 |
| 3 | Direct coronary vasodilator action of adrenomedullin is mediated by nitric oxide显示文摘 | De MATTEO R MAY C N | 2003 | Br J Pharmacol2003，140，8： | 2 |
| 4 | Direct cardiac and vascular action of adrenomedullin in conscious sheep 显示文摘 | PARKES D G MAY C N | 1997 | Br J Pharmacol1997，120，6： | 2 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | Flow-based multiadsorbate ellipsometric porosimetry for the characterization of mesoporous Pt- TiO2 and Au-TiO2 nanocomposites显示文摘 | May R A Patel M N Johnston K P | 2009 | Langmuir2009，25，8： | 1 |
| 7 | Characterization and device applications of ZnO films deposited by high power impulse magnetron sputtering (HiPIMS) 显示文摘 | Partridge J G Mayes E L H McDougall N L | 2013 | J Phys D: Appl Phys2013，46，16： | 1 |
| 8 | Overexpression of Sbe2p,a Golgi protein,results in resistance to caspofungin in Saccharomyces cerevisiae显示文摘 | OSHEROV N MAY G S ALBERT N D | 2002 | Antimicrob Agents Chemother2002，46，： | 1 |
| 9 | Somatic embryogenesis and plant regeneration from leaves of Dendranthema grandiflora 显示文摘 | MAY R A TRIGIANO R N | 1991 | J Amer Soc Hort Sci1991，116，2： | 1 |
| 10 | The effect of alkaline pretreatment on the thermal decomposition of hemp显示文摘 | Sebestyén Z May Z Réczey K | 2011 | Journal of Thermal Analysis and Calorimetry2011，105，3： | 1 |
| 11 | Temporary skin transplantation and immunosuppression for extensive burns显示文摘 | May JW Albright N | 1974 | N Engl J Med1974，290，5： | 1 |
| 12 | Comparative study of imprinted polymer particles prepared by different polymerisation methods 显示文摘 | PEREZ-MORAL N MAYES A G | 2004 | Anal Claim Acta2004，504，： | 1 |
| 13 | Chemical and electrochemical basis of bioleaching processes显示文摘 | May N | 1999 | Minerals Engineering1999，10，9： | 1 |
| 14 | The swarming motility of Pseudomonas aeruginosais blocked by cranberry proanthocyanidins and othertannin-containing materials显示文摘 | O′May C Tufenkji N | 2011 | Appl Environ Microbiol2011，77，9： | 1 |
| 15 | Field emission conduction mechanisms in chemical-vapour-deposited diamond and diamond-like carbon films显示文摘 | Kuo M T Ashfold M N R | 1999 | Diamond Relat Mater1999，，8： | 1 |
| 16 | Acute small bowel obstruction due to internal herniation through the Foramen of Winslow: CT diagnosis and laparoseopic treatment显示文摘 | May A1 Cazeneuve N Bourbao-Tournois C | 2013 | J Vise Surg2013，150，5： | 1 |
| 17 | Mechanisms for the generation of mesoscale vorticity features in tropical cyclone rainbands显示文摘 | Franklin C N Holland G J May P T | | 0，，： | 1 |
| 18 | 显示文摘 | Mariano N A Souza C A C May J E | 2006 | Mater Sci Eng2006，354，： | 1 |
| 19 | Locus-specific amplification of HLA class I genes from genomic DNA:locus-specific sequences in the first and third introns of HLA-A,-B,and-C alleles显示文摘 | Cereb N Maye P Lee S | 1995 | Tissue antigens1995，45，1： | 1 |
| 20 | Novel approaches to the estimation of intake and bioavailability of radiocaesium in ruminants grazing forested areas显示文摘 | Mayes R M Beresford N A Lamb C S | 1994 | Science of the Total Environment1994，，157： | 1 |
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