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| 1 | New advances on glial activation in health and disease显示文摘In addition to being the support cells of the central nervous system(CNS), astrocytes are now recognized as active players in the regulation of synaptic function, neural repair, and CNS immunity. Astrocytes are among the most structurally complex cells in the brain, and activation of these cells has been shown in a wide spectrum of CNS injuries and diseases. Over the past decade, research has begun to elucidate the role of astrocyte activation and changes in astrocyte morphology in the progression of neural pathologies, which has led to glial-specific interventions for drug development. Future therapies for CNS infection, injury,and neurodegenerative disease are now aimed at targeting astrocyte responses to such insults including astrocyte activation, astrogliosis and other morphological changes, and innate and adaptive immune responses. | Kim Mai Lee Andrew G Mac Lean | 2015 | World Journal of Virology2015，4，2： | 13 |
| 2 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 3 | Research progress in electrospinning engineering for all-solid-state electrolytes of lithium metal batteries显示文摘Owing to safety issue and low energy density of liquid lithium-ion batteries(LIBs),all-solid-state lithium metal batteries(ASLMBs)with unique all-solid-state electrolytes(SEs)have attracted wide attentions.This arises mainly from the advantages of the SEs in the suppression of lithium dendrite growth,long cycle life,and broad working temperature range,showing huge potential applications in electronic devices,electric vehicles,smart grids,and biomedical devices.However,SEs suffer from low lithiumion conductivity and low mechanical integrity,slowing down the development of practical ASLMBs.Nanostructure engineering is of great efficiency in tuning the structure and composition of the SEs with improved lithium-ion conductivity and mechanical integrity.Among various available technologies for nanostructure engineering,electrospinning is a promising technique because of its simple operation,cost-effectiveness,and efficient integration with different components.In this review,we will first give a simple description of the electrospinning process.Then,the use of electrospinning technique in the synthesis of various SEs is summarized,for example,organic nanofibrous matrix,organic/inorganic nanofibrous matrix,and inorganic nanofibrous matrix combined with other components.The current development of the advanced architectures of SEs through electrospinning technology is also presented to provide references and ideas for designing high-performance ASLMBs.Finally,an outlook and further challenges in the preparation of advanced SEs for ASLMBs through electrospinning engineering are given. | Manxi Wang Yaling Wu Min Qiu Xuan Li Chuanping Li Ruiling Li Jiabo He Ganggang Lin Qingrong Qian Zhenhai Wen Xiaoyan Li Ziqiang Wang Qi Chen Qinghua Chen Jinhyuk Lee Yiu-Wing Mai Yuming Chen | 2021 | Journal of Energy Chemistry2021，30，10： | 4 |
| 4 | Near-fault ground motions with prominent acceleration pulses:pulse characteristics and ductility demand显示文摘Major earthquakes of last 15 years (e.g., Northridge 1994, Kobe 1995 and Chi-Chi 1999) have shown that many near-fault ground motions possess prominent acceleration pulses. Some of the prominent ground acceleration pulses are related to large ground velocity pulses, others are caused by mechanisms that are totally different from those causing the velocity pulses or fling steps. Various efforts to model acceleration pulses have been reported in the literature. In this paper, research results from a recent study of acceleration pulse prominent ground motions and an analysis of structural damage induced by acceleration pulses are summarized. The main results of the study include: (1) temporal characteristics of acceleration pulses; (2) ductility demand spectrum of simple acceleration pulses with respect to equivalent classes of dynamic systems and pulse characteristic parameters; and (3) estimation of fundamental period change under the excitation of strong acceleration pulses. By using the acceleration pulse induced linear acceleration spectrum and the ductility demand spectrum, a simple procedure has been developed to estimate the ductility demand and the fundamental period change of a reinforced concrete (RC) structure under the impact of a strong acceleration pulse. | Mai Tong Vladimir Rzhevskyt Dai Junwu George C Lee Qi Jincheng Qi Xiaozhai | 2007 | Earthquake Engineering and Engineering Vibration2007，6，3： | 3 |
| 5 | Distributed adaptive Top- k monitoring in wireless sensor networks显示文摘 | H T Mai Y W Lee K Y Lee | 2011 | Journal of Sys- tems and Software2011，84，2： | 1 |
| 6 | Lipase - catalyzed Biodiesel Production From Soybean Oil in Ionic Liquids显示文摘 | Sung Ho Ha Mai Ngoc Lan Sang Hyun Lee | 2007 | Enzyme and Microbial Technology2007，，： | 1 |
| 7 | Optimization methodology for damper configuration based on building performance indices显示文摘 | LIU Wei TONG Mai LEE G C | 2005 | Journal of Structural Engineering2005，131，11： | 1 |
| 8 | Approach to improve ZnO-based FBAR devices显示文摘 | MAI L LEE J Y YOON G | 2007 | Electron Lett2007，43，13： | 1 |
| 9 | Protective mocha nism of Salvia miltiorrhiza on carbon tetrachloride in duced acute hepatotoxicity in rats 显示文摘 | Lee T Mai LM Wang GJ | 2003 | J pharmaeological sciences2003，91，3： | 1 |
| 10 | Anther developmental defects in Arabidopsis thaliana male-sterile mutants显示文摘 | Paul M. Sanders Anhthu Q. Bui Koen Weterings K. N. McIntire Yung-Chao Hsu Pei Yun Lee Mai Thy Truong T. P. Beals R. B. Goldberg | 1999 | Sexual Plant Reproduction1999，，6： | 1 |
| 11 | Lipase-catalyzed biodiesel production from soybean oil in ionic liquids 显示文摘 | Sung Ho Ha Lan Mai Ngoc Lee Sang Hyun | 2007 | Enzyme and Microbial Technology2007，41，3： | 1 |
| 12 | Anther developmental defects in Arabidopsis thaliana male-sterile mutants显示文摘 | Paul M. Sanders Anhthu Q. Bui Koen Weterings K. N. McIntire Yung-Chao Hsu Pei Yun Lee Mai Thy Truong T. P. Beals R. B. Goldberg | 1999 | Sexual Plant Reproduction1999，，6： | 1 |
| 13 | Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis显示文摘 | Pierre Blanchard Anne Lee Sophie Marguet Julie Leclercq Wai Tong Ng Jun Ma Anthony T C Chan Pei-Yu Huang Ellen Benhamou Guopei Zhu Daniel T T Chua Yong Chen Hai-Qiang Mai Dora L W Kwong Shie Lee Cheah James Moon Yuk Tung Kwan-Hwa Chi George Fountzilas Li | 2015 | The Lancet Oncology2015，，： | 1 |
| 14 | Anther developmental defects in Arabidopsis thaliana male-sterile mutants显示文摘 | Paul M. Sanders Anhthu Q. Bui Koen Weterings K. N. McIntire Yung-Chao Hsu Pei Yun Lee Mai Thy Truong T. P. Beals R. B. Goldberg | 1999 | Sexual Plant Reproduction1999，，6： | 1 |
| 15 | Protective mechanism of salvia miltiorrhiza on carbon tetrachloride-induced acute hepatotoxicity in rats 显示文摘 | Lee T Y Mai L M Wang G J | 2003 | J Pharmacol Sci2003，91，： | 1 |
| 16 | Anther developmental defects in Arabidopsis thaliana male-sterile mutants显示文摘 | Paul M. Sanders Anhthu Q. Bui Koen Weterings K. N. McIntire Yung-Chao Hsu Pei Yun Lee Mai Thy Truong T. P. Beals R. B. Goldberg | 1999 | Sexual Plant Reproduction1999，，6： | 1 |
| 17 | KHA-CARI Autosomal Dom- inant Polycystic Kidney Disease Guideline:Management of Intracra- nial Aneurysms 显示文摘 | Lee V W Dexter M A Mai J | 2015 | Semin NepKrol2015，35，6： | 1 |
| 18 | Nationalboard certified physical educators:background characteristics,subjective warrants,and motivations显示文摘 | Woods Amelia Mays Rhoades Jesse Lee | 2010 | Journalof Teaching in Physical Education2010，29，3： | 1 |
| 19 | A Framework for Multiple Ontology Integration of Multi- lingual Ontologies in Web Environment 显示文摘 | Dosam Hwang In Keun Lee Ho Mai Thi Pham | 2010 | Information2010，，5： | 1 |
| 20 | Inhibitory effects of isoquinoline alkaloid berberine on ischemia- induced apoptosis via activation of phosphoinositide 3-kinase/protein kinase B signaling pathway显示文摘 | Mia Kim Mai Soon Shin Jae Min Lee | 2014 | Int Neurourol J2014，18，3： | 1 |
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