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| 1 | Adhesive small bowel adhesions obstruction: Evolutions in diagnosis, management and prevention显示文摘Intra-abdominal adhesions following abdominal surgery represent a major unsolved problem. They are the first cause of small bowel obstruction. Diagnosis is based on clinical evaluation, water-soluble contrast followthrough and computed tomography scan. For patients presenting no signs of strangulation, peritonitis or severe intestinal impairment there is good evidence to support non-operative management. Open surgery is the preferred method for the surgical treatment of adhesive small bowel obstruction, in case of suspected strangulation or after failed conservative management, but laparoscopy is gaining widespread acceptance especially in selected group of patients. 'Good' surgical technique and anti-adhesive barriers are the main current concepts of adhesion prevention. We discuss current knowledge in modern diagnosis and evolving strategies for management and prevention that are leading to stratified care for patients. | Fausto Catena Salomone Di Saverio Federico Coccolini Luca Ansaloni Belinda De Simone Massimo Sartelli Harry Van Goor | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 28 |
| 2 | Ultrasound detection of abdominal lymphadenomegaly in subjects with hepatitis C virus infection and persistently normal transaminases:a predictive index of liver histology severity显示文摘UltrasounddetectionofabdominallymphadenomegalyinsubjectswithhepatitisCvirusinfectionandpersistentlynormaltransaminases:apredi... | Maurizio Soresi, Antonio Carroccio, Giulio Bonfissuto, Vincenzo Agate 1, Carmela Magliarisi, Federico Aragona 1, Massimo Levrero 2, Alberto Notarbartolo and Giuseppe Montalto Cattedra di Medicina Interna, 1Istituto di Anatomia Patologica, Univ | 1998 | World Journal of Gastroenterology1998，4，3： | 15 |
| 3 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 4 | Antimicrobial management of intra-abdominal infections:Literature's guidelines显示文摘Antimicrobial management of severe intra-abdominal infections (IAIs) involves a delicate balance of optimizing empirical therapy,which has been shown to improve clinical outcomes,while simultaneously reducing unnecessary antimicrobial use.Two sets of guidelines for the management of intra-abdominal infections were recently published.In 2010,the Surgical Infection Society and the Infectious Diseases Society of America (SIS-IDSA) created guidelines for the diagnosis and management of complicated IAIs.The new SIS-IDSA guidelines replace those previously published in 2002 and 2003.The World Society of Emergency Surgery (WSES) guidelines represent additional contributions,made by specialists worldwide,to the debate regarding proper antimicrobial drug methodology.These guidelines represent the conclusions of the consensus conference held in Bologna,Italy,in July 2010 during the first congress of the WSES. | Massimo Sartelli Fausto Catena Federico Coccolini Antonio Daniele Pinna | 2012 | World Journal of Gastroenterology2012，18，9： | 7 |
| 5 | Peritoneal carcinosis of ovarian origin显示文摘Epithelial ovarian cancer (EOC) is the second most common genital malignancy in women and is the most lethal gynecological malignancy,with an estimated five-year survival rate of 39%.Despite efforts to develop an effective ovarian cancer screening method,60% of patients still present with advanced disease.Comprehensive management using surgical cytoreduction to decrease the tumor load to aminimum,and intraperitoneal chemotherapy to eliminate microscopic disease on peritoneal surface,has the potential to greatly improve quality of life and to have an impact on survival in ovarian cancer patients.Despite achieving clinical remission after completion of initial treatment,most patients (60%) with advanced EOC will ultimately develop recurrent disease or show drug resistance;the eventual rate of curability is less than 30%.Given the poor outcome of women with advanced EOC,it is imperative to continue to explore novel therapies. | Anna Fagotti Valerio Gallotta Federico Romano Francesco Fanfani Cristiano Rossitto Angelica Naldini Massimo Vigliotta Giovanni Scambia | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 5 |
| 6 | Laparoscopic management of intra-abdominal infections:Systematic review of the literature显示文摘AIM: To investigate the role of laparoscopy in diagnosis and treatment of intra abdominal infections.METHODS: A systematic review of the literature was performed including studies where intra abdominal infections were treated laparoscopically.RESULTS: Early laparoscopic approaches have become the standard surgical technique for treating acute cholecystitis. The laparoscopic appendectomy has been demonstrated to be superior to open surgery in acute appendicitis. In the event of diverticulitis, laparoscopic resections have proven to be safe and effective procedures for experienced laparoscopic surgeons and may be performed without adversely affecting morbidity and mortality rates. However laparoscopic resection has not been accepted by the medical community as the primary treatment of choice. In high-risk patients, laparoscopic approach may be used for exploration or peritoneal lavage and drainage. The successful laparoscopic repair of perforated peptic ulcers for experienced surgeons, is demonstrated to be safe and effective. Regarding small bowel perforations, comparative studies contrasting open and laparoscopic surgeries have not yet been conducted. Successful laparoscopic resections addressing iatrogenic colonic perforation have been reported despite a lack of literature-based evidence supporting such procedures. In post-operative infections, laparoscopic approaches may be useful in preventing diagnostic delay and controllingthe source.CONCLUSION: Laparoscopy has a good diagnostic accuracy and enables to better identify the causative pathology; laparoscopy may be recommended for the treatment of many intra-abdominal infections. | Federico Coccolini Cristian Tranà Massimo Sartelli Fausto Catena Salomone Di Saverio Roberto Manfredi Giulia Montori Marco Ceresoli Chiara Falcone Luca Ansaloni | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 5 |
| 7 | Laparoscopic splenectomy for a littoral cell angioma of the spleen: Case report显示文摘A littoral cell angioma(LCA) is a primary vascular tumor of the spleen, that can have malignant potential and may present association with other malignancies. This is a case of LCA that was discovered incidentally in a 79-year-old woman who presented with a polycythemia at the time of consultation. The neoplasm was evaluated by ultrasound and computed tomography. The patient underwent a splenectomy that revealed LCA by pathological evaluation. The post-operative outcome was favorable with no complications or recurrent disease. This case presentation, clinical, radiographic, and pathological features of an uncommon splenic tumor can be studied in order to advance our knowledge in our understanding of LCA. | Alice Marzetti Federico Messina Daniela Prando Luca A Verza Ugo Vacca Alireza Azabdaftari Leonardo Rubinato Domenico Reale Massimo Favat Mario Barbujani Ferdinando Agresta | 2015 | World Journal of Clinical Cases2015，3，11： | 3 |
| 8 | Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of three randomised trials显示文摘 | Massimo Di Maio Cesare Gridelli Ciro Gallo Frances Shepherd Franco Vito Piantedosi Silvio Cigolari Luigi Manzione Alfonso Illiano Santi Barbera Sergio Federico Robbiati Luciano Frontini Elena Piazza Giovanni Pietro Ianniello Enzo Veltri Federico Castiglio | 2005 | Lancet Oncology2005，，9： | 2 |
| 9 | Epidemiological network analysis in HIV-1 B infected patients diagnosed in Italy between 2000 and 2008显示文摘 | Annapaola Callegaro Valentina Svicher Claudia Alteri Alessandra Lo Presti Daniela Valenti Antonio Goglio Marco Salemi Eleonora Cella Carlo Federico Perno Massimo Ciccozzi Franco Maggiolo | 2011 | Infection, Genetics and Evolution2011，，3： | 2 |
| 10 | Hemophagocytic lymphohistiocytosis caused by primary Epstein-Barr virus in patient with Crohn's disease显示文摘We present a case of a 19-year-old man with a 6-year history of Crohn's disease(CD), previously treated with 6-mercaptopurine, who was admitted to our department for Epstein-Barr virus(EBV) infection and subsequently developed a hemophagocytic lymphohistiocytosis(HLH). HLH is a rare disease which causes phagocytosis of all bone marrow derived cells. It can be a primary form as a autosomic recessive disease, or a secondary form associated with a variety of infections; EBV is the most common, the one with poorer prognosis. The incidence of lymphoproliferative disorders was increased in patients with inflammatory bowel disease(IBD) treated with thiopurines. Specific EBV-related clinical and virological management should be considered when treating a patient with IBD with immunosuppressive therapy. Moreover EBV infection in immunosuppressed patient can occur with more aggressive forms such as encephalitis and diffuse large B cell lymphoma. Our case confirms what is described in the literature; patients with IBD, particularly patients with CD receiving thiopurine therapy, who present 5 d of fever and cervical lymphadenopathy or previous evidence of lymphopenia should be screened for HLH. | Francesco Virdis Sara Tacci Federico Messina Massimo Varcada | 2013 | World Journal of Gastrointestinal Surgery2013，5，11： | 2 |
| 11 | Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors显示文摘During the last decades,further knowledge of hepatocellular carcinoma(HCC)molecular mechanisms has led to development of effective systemic treatments including tyrosine kinase inhibitors(TKIs)and immunotherapy.In this review,we describe first and second line systemic treatment options for advanced HCC.Several trials have evaluated new drugs for the treatment of HCC patients:In first line,lenvatinib resulted non-inferior to sorafenib and it can be used as alternative,even in the lack of evidence for sequential treatment options in second line after lenvatinib.Recently,atezolizumab plus bevacizumab have shown superiority over sorafenib in first-line.Sorafenib-regorafenib sequential administration in selected patients has opened a new paradigm of treatment in advanced HCC with a life expectancy exceeding two years.Other TKIs for second line treatment include cabozantinib and ramucirumab(specifically for patients with Alpha-fetoprotein values≥400 ng/mL).The combination of TKIs with immunotherapy may represent a big step forward for these patients in the near future. | Federico Pinero Marcelo Silva Massimo Iavarone | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 12 | Stereovision system for estimating tractors and agricultural machines transit area under orchards canopy显示文摘Managing orchards requires delicate agricultural operations being typically carried out in narrow zones where the operators usually drive machineries under stress that could result in poor performance.In such conditions,the use of technology would help manage the machines to reduce the hazardous work and eventual damage to the plants.To safely drive a tractor,the driver needs to be aware of its surroundings,thus a stereovision system can provide helpful information.Stereo imaging has proven to be an effective three-dimensional vision system.Indeed,the range(or third coordinate)information is useful to detect the obstacle distances.Such distances,when detected during agricultural operations,could be used to assist the operator in driving the tractor at regular or variable working speeds and eventually to provide manufacturers useful indications to model the form of ROPS(roll over protection structure).This study aimed to verify the closeness of agreement between manual and stereo-image measurements,and thus to provide helpful information regarding safety and working purposes.The system used a custom low-cost dual web-camera in combination with an image analysis algorithm in order to automatically extract the information needed.Manual independent measurements were carried out using a metric tape(sensitivity 1 cm).A regular structure was used for the analysis:four rows of ten trees each one.Alternated red and blue paper markers were placed on the hazelnut trees(two per tree)of two couples of rows for enhanced visibility.For each couple of trees(one on the right,the other on the left),the four markers formed a trapezoid that was measured.The results of the analysis demonstrated that the stereo vision provided distance measurements with reasonable accuracy(error<5%)in the range of distances lower than 20 m.The resolution assessed for the developed video system is suitable for obtaining distance information in real scenes.This information could be used to assist drivers to operate agricultural machineries through narrow tree rows during work execution.Moreover,such information could be used for safeguarding decision-making and/or for controlling some tractor functions such as continuing moving,changing driving direction,changing 3-point hitch position,reducing transmission speed,halting the tractor.These functions will be necessary before tractors become fully autonomous.Finally,the measured distances,marking the narrow transitions between the tree rows,could be also used to study the ROPS form,both for working safely and for avoiding possible damage caused to the hazel trees laterally. | Corrado Costa Paolo Febbi Federico Pallottino Massimo Cecchini Simone Figorilli Francesca Antonucci Paolo Menesatti | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 1 |
| 13 | Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts显示文摘 | Heikki Joensuu Aki Vehtari Jaakko Riihim?ki Toshirou Nishida Sonja E Steigen Peter Brabec Lukas Plank Bengt Nilsson Claudia Cirilli Chiara Braconi Andrea Bordoni Magnus K Magnusson Zdenek Linke Jozef Sufliarsky Massimo Federico Jon G Jonasson Angelo Paolo | 2012 | Lancet Oncology2012，，3： | 1 |
| 14 | De- sign for disassembly:a method-ology for identifying the opti- mal disassembly sequence 显示文摘 | Federico Cappelli Massimo Delogu Marco Pierini | 2007 | Journal of Engineering De- sign2007，18，6： | 1 |
| 15 | Atypical (mid-ventricular) Takotsubo syndrome in a survival of out-of-hospital ventricular fibrillation: Cause or consequence?显示文摘 | Nicola Gasparetto Alessandro Zorzi Martina Perazzolo Marra Federico Migliore Massimo Napodano Domenico Corrado Sabino Iliceto Luisa Cacciavillani | 2013 | International Journal of Cardiology2013，，： | 1 |
| 16 | Risk Factors and Prognostic Indicators of Bacterial Meningitis in a Cohort of 3580 Postneurosurgical Patients显示文摘 | Giovanni Federico Mario Tumbarello Teresa Spanu Romeo Roselli Maurizio Iacoangeli Massimo Scerrati Evelina Tacconelli | 2001 | Scandinavian Journal of Infectious Diseases2001，，7： | 1 |
| 17 | Extrahepatic Textiloma Long Misdiagnosed as Calcified Echinococcal Cyst显示文摘 | Federico Cattaneo Massimo Graffeo Enrico Brunetti D. A. Edelman I. D. Kyriazanos | 2013 | Case Reports in Gastrointestinal Medicine2013，，： | 1 |
| 18 | Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts显示文摘 | Heikki Joensuu Aki Vehtari Jaakko Riihim?ki Toshirou Nishida Sonja E Steigen Peter Brabec Lukas Plank Bengt Nilsson Claudia Cirilli Chiara Braconi Andrea Bordoni Magnus K Magnusson Zdenek Linke Jozef Sufliarsky Massimo Federico Jon G Jonasson Angelo Paolo | 2012 | Lancet Oncology2012，，3： | 1 |
| 19 | CAN-Labview Based Development Platform for Fine-tuning Hybrid Vehicle Management Systems 显示文摘 | Massimo Ceraolo Paolo Capozzella Federico Baronti | 2005 | IEEE Transactions on Energy Conversion2005，17，9： | 1 |
| 20 | NGAL: a biomarker of acute kidney injury and other systemic conditions显示文摘 | Sachin S. Soni Dinna Cruz Ilona Bobek Chang Yin Chionh Federico Nalesso Paolo Lentini Massimo Cal Valentina Corradi Grazia Virzi Claudio Ronco | 2010 | International Urology and Nephrology2010，，1： | 1 |
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