|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 低社会经济地位与美国成年人早发冠状动脉粥样硬化性心脏病的关系显示文摘低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险因素和与低SES相关因素影响所占的比例。 | Hamad R Penko J Kazi DS Coxson P Guzman D Pengxiao C.Wei Mason A Wang EA Goldman L Fiscella K Bibbins-Domingo K 周卫(译) 刘莉(审校) | 2020 | 中华高血压杂志2020，28，7： | 7 |
| 2 | OPTIMIZATION OF A WAVE CANCELLATION MULTIHULL SHIP USING CFD TOOLS显示文摘A simple CFD tool, coupled to a discrete surface representation and a gradient based optimization procedure, is applied to the design of optimal hull forms and optimal arrangement of hulls for a wave cancellation multihull ship. The CFD tool, which is used to estimate the wave drag, is based on the zeroth order slender ship approximation. The hu ll surface is represented by a triangulation, and almost every grid point on the surface can be used as a design variable. A smooth surface is obtained via a si mplified pseudo shell problem. The optimal design process consists of two steps . The optimal center and outer hull forms are determined independently in the fi rst step, where each hull forms are determined independently in the first step, where each hull keeps the same displacement as the original design while the wav e drag is minimized. The optimal outer hull arrangement is determined in the se cond step for the optimal center and outer hull forms obtained in the first step . Results indicate that the new design can achieve a large wave drag reduction i n comparison to the original design configuration. | C. Yang, R. L■hner, O. Soto (School of Computational Sciences, George Mason University Fairfax VA 22030-4444, USA) | 2002 | Journal of Hydrodynamics2002，14，1： | 5 |
| 3 | Combination antiretroviral studies for patients with primary biliary cirrhosis显示文摘Following the characterization of a human betaretrovirus in patients with primary biliary cirrhosis(PBC),pilot studies using antiretroviral therapy have been conducted as proof of principal to establish a link of virus with disease and with the eventual aim to find better adjunct therapies for patients unresponsive to ursodeoxycholic acid.In the first open label pilot study,the reverse transcriptase inhibitor lamivudine had little demonstrable biochemical or histological effect after 1 year.Whereas,lamivudine in combination with zidovudine was associated with a significant reduction in alkaline phosphatase as well as improvement in necroinflammatory score,cholangitis and ductopenia over a 12 mo period.A double blind,multi-center randomized controlled trial using lamivudine with zidovudine for 6 mo confirmed a significant reduction in alkaline phosphatase,ALT and AST in patients on antiviral therapy.However,none of the patients achieved the stringent endpoint criteria for normalization of alkaline phosphatase.Furthermore,some patients developed biochemical rebound consistent with drug resistance.A major fault of these studies has been the inability to measure the viral load in peripheral blood and therefore,provide a direct correlation between improvement of hepatic biochemistry and reduction in viral load.Nevertheless,viral mutants to lamivudine with zidovudine were later characterized in the NOD.c3c4 mouse model of PBC that has been used to test other antiretroviral regimens to betaretrovirus.The combination of tenofovir and emtricitabine reverse transcriptase inhibitors and the HIV protease inhibitor,lopinavir were found to abrogate cholangitis in the NOD.c3c4 mouse model and the same regimen normalized the liver tests in a PBC patient with HIV and human betaretrovirus infection.This combination antiretroviral therapy has now been used in a double blind randomized controlled crossover study for patients with PBC followed by an open label extension study.Only a third of the PBC patients were able to tolerate the lopinavir but those maintained on tenofovir,emtricitabine and lopinavir experienced sustained and clinically meaningful reduction in hepatic biochemistry.While we await the histological and virological evaluation,it is clear that better tolerated regimens of antiretroviral treatment will be required in future clinical trials. | Ellina Lytvyak Aldo J Montano-Loza Andrew L Mason | 2016 | World Journal of Gastroenterology2016，22，1： | 2 |
| 4 | Detection of retroviral antibodies in primary biliary cirrhosis and other idiopathic biliary disorders显示文摘 | Mason AL Xu L Guo L | 1998 | Lancet1998，351，9116： | 2 |
| 5 | Lethality and centrality in protein networks显示文摘 | Jeong H Mason S P Barabasi A L | 2001 | Nature2001，411，： | 1 |
| 6 | In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody显示文摘 | Mason K Hunter N | 2000 | Clin Cancer Res2000，6，： | 1 |
| 7 | Lethality and centrality in protein networks显示文摘 | Jeong H Mason S P Barabasi A L | 2001 | Nature2001，411，6833： | 1 |
| 8 | Design, synthesis, and anfiviral activity of 2'-deoxy- 2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication显示文摘 | CLARK L J HOLLECKER L MASON C J | 2005 | J Med Chem2005，48，17： | 1 |
| 9 | Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high -risk individuals and inhibits replication in vitro显示文摘 | Golden -Mason L Cox AL Randall JA | 2010 | J hepatol2010，52，5： | 1 |
| 10 | Enhanced electron injection in organic electroluminescence devices using an Al/LiF electrode 显示文摘 | Hung L S Tang C W Mason M G | 1997 | Appl Phys Lett1997，70，： | 1 |
| 11 | Variational finite element calculation of the acoustic response of a rectangular panel显示文摘 | Gladwell G M L Mason V | 1971 | Sound and Vibration1971，14，1： | 1 |
| 12 | Differentiation of beach , dune and aeolian flat environment by size analysis 显示文摘 | Mason C C Folk R L | 1958 | Journal of Sedimentary Petrology1958，28，： | 1 |
| 13 | Enhancement of tum- or response to e-radiation by an inhibitor of cyclooxi- dase-2 enzyme显示文摘 | Gallo O Milas L Mason K | 2000 | Natl Cancer lnst2000，92，4： | 1 |
| 14 | Quality of life following ampu- tation or limb preservation in patients with lower extremity bone sarcoma显示文摘 | Mason G E Aung L Gall S | 2013 | Front Oncol2013，3，： | 1 |
| 15 | Fairness in network optimal flow control: optimality of product forms显示文摘 | MAZUMDAR R MASON L G DOULIGERIS C | 2004 | IEEE Trans on Commun2004，39，5： | 1 |
| 16 | On the current status of quartz crystal microbalance studies of superconductivity-dependent sliding friction显示文摘 | MASON B L WINDER S M KRIM J | 2001 | Tribology Letters2001，10，12： | 1 |
| 17 | On the stability of switched positive linear systems显示文摘 | GURVITS L SHORTEN R MASON O | 2007 | IEEE Trans on Automatic Control2007，52，6： | 1 |
| 18 | Maximizing therapeutic gain with gemcitabine and fractionated radiation显示文摘 | Mason KA Milas L Hunter NR | 1999 | Int J Radiat Oncol Biol Phys1999，44，5： | 1 |
| 19 | CpG oligodeoxynuclvotide enhances tumor response to radiation 显示文摘 | Milas L Mason KA Ariga H | 2004 | Cancer Res2004，64，15： | 1 |
| 20 | Enhanced electron injection in organic electroluminescence devices using an Al/LiF electrode显示文摘 | HUNG L S TANG C W MASON M G | 1997 | Appl Phys Lett1997，70，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员