|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?显示文摘Helicobacter pylori(H.pylori)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human population.Infection is a risk factor for gastritis,ulcer disease and stomach cancer.Immunity against H.pylori is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including cancer.Furthermore,host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases.In this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H.pylori and discuss how such polymorphisms may influence infection/disease outcomes. | Camila A Figueiredo Cintia Rodrigues Marques Ryan dos Santos Costa Hugo Bernardino F da Silva Neuza M Alcantara-Neves | 2014 | World Journal of Gastroenterology2014，20，18： | 11 |
| 2 | 高纤维膳食和补充乙酸盐改变肠道菌群,预防醋酸脱氧皮质酮-盐型高血压小鼠高血压和心力衰竭的发展显示文摘水果和蔬菜的膳食摄入与高血压的发生率较低有关,但所涉及的机制尚未阐明。该研究评估了高纤维膳食和短链脂肪酸(short-chain fatty acid,SCFA)(乙酸盐)对肠道微生物群和预防心血管病的影响。方法:用盐皮质激素诱发小鼠高血压模型,观测正常喂食组、高纤维喂食组和补充乙酸盐组的肠道微生物、心脏结构/功能和血压水平。 | 刘莉 叶鹏 Marques FZ Nelson EM Chu PY Horlock D Fiedler A Ziemann M Tan JK Kuruppu S Rajapakse NW El-Osta A Mackay CR Kaye DM | 2016 | 中华高血压杂志2016，24，12： | 8 |
| 3 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 4 | 膳食硝酸盐通过减少交感神经过度激活的机制降低血管紧张素Ⅱ诱导的高血压大鼠的血压显示文摘几项实验和临床研究表明,膳食中添加硝酸盐可提高一氧化氮的生物利用度。在口腔中,共生细菌将硝酸盐还原成亚硝酸盐,其随后被吸收到循环中,通过酶系统还原为一氧化氮。已知增加硝酸盐-亚硝酸盐-一氧化氮途径可以改善心血管、肾脏和代谢功能,并且交感神经兴奋有助于疾病的进展,但是膳食硝酸盐对交感神经活动的潜在影响仍有待阐明。 | 刘莉 叶鹏 ■ DD Cruz JC ■ A Zhuge Z Marques SM Naves LM Persson AEG Weitzberg E Lundberg JO Balarini CM Pedrino GR Braga VA ■ M | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 5 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 6 | The 200th horizontal openhole gravel-packing operation in Campos Basin: a milestone in the history of petrohras completion practices in ultradeep waters显示文摘 | Marques L C C Paixao L C A Martions M O | 2007 | SPE1063642007，，： | 1 |
| 7 | Extraction of the soluble material from the shells of the bacuri fruit (Platonia insignis Mart) with pressurized CO2 and other solvents 显示文摘 | Monteiro A R Meireles M A Marques M O M | 1997 | J Supercrit Fluids1997，11，： | 1 |
| 8 | Fresenius' J Anal Chem显示文摘 | Marques M J Salvador A Morales-Rubio A | 2000 | 367: 601-6132000，367，： | 1 |
| 9 | Detection and confirmation of chloramphenicol in milk by high performance liquid chromatography-tandem mass spectrometry 显示文摘 | Nicolich R S Werneck-Barroso E Sipoli Marques M A | 2006 | Analytica Chimica Acta2006，565，： | 1 |
| 10 | Biogenic amines in wines: influence of oenological factors显示文摘 | MARQUES A P LEITAO M C SAN ROMAO M V | 2008 | Food Chemistry2008，107，2： | 1 |
| 11 | Modelling of anethanol-water distillation column assisted by an external heat pump显示文摘 | Oliveira S B M Parise J A R Pitanga Marques R | 2002 | International Journal of Energy Research2002，26，12： | 1 |
| 12 | In vitro response of the brown bullhead catfish( BB ) and rainbow trout( RTG-2 ) cell lines to benzo pyrene 显示文摘 | Araujo C S A Marques S A F Carrondo M J T | 2000 | Science of the Total Environment2000，247，2： | 1 |
| 13 | Simple and rapid method determination for metformin in human plasma using high performance liquid chromatography tandem mass spectrometry: application to pharmacokinetic studies 显示文摘 | S'lpoli Marques M A Soares A S Pinto O W | 2007 | Chromatography B2007，852，： | 1 |
| 14 | Market Orientation and Performance: Modelling a Neural Network 显示文摘 | Silva M Moutinho L Coelho A Marques A | 2009 | European Journal of Marketing2009，43，3： | 1 |
| 15 | Assessment of genetic damage induced by dental bleaching agents on mouse lymphoma cells by single cell gel (comet) assay显示文摘 | Ribeiro D A Marques M E Salvadori D M | 2005 | J Oral Rehabil2005，32，10： | 1 |
| 16 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 17 | Polypropylene degra- dation : Theoretical and experimental investigations 显示文摘 | Bertin D Leblanc M Marque S R A | 2010 | Polym Degrad Stab2010，95，5： | 1 |
| 18 | Oxygen and electronic transport in apatite-type La10-x(Si,Al)6)26显示文摘 | SHAULA A L KHARTON V V MARQUES F M B | 2005 | Journal of Solid State Chemistry2005，178，： | 1 |
| 19 | Extraction of ginger (Zingiber officinale Roscoe) oleoresin with CO2 and co-solvents: A study of the antioxidant action of the extracts 显示文摘 | Zancan K C Marques M O M Petenate A J | 2002 | J Supercrit Fluids2002，24，1： | 1 |
| 20 | U- niversity-industry collaboration and innovation in emergent and mature industries in new industrialized countries显示文摘 | FREITAS I M B MARQUES R A SILVA E M D P | 2013 | General Information2013，42，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员