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| 1 | Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis显示文摘BACKGROUND Timely differentiation of biliary atresia(BA)from other infantile cholestatic diseases can impact patient outcomes.Additionally,non-invasive staging of fibrosis after Kasai hepatoportoenterostomy has not been widely standardized.Shear wave elastography is an ultrasound modality that detects changes in tissue stiffness.The authors propose that the utility of elastography in BA can be elucidated through meta-analysis of existing studies.AIM To assess the utility of elastography in:(1)BA diagnosis,and(2)post-Kasai fibrosis surveillance.METHODS A literature search identified articles that evaluated elastography for BA diagnosis and for post-Kasai follow-up.Twenty studies met criteria for meta-analysis:Eleven for diagnosis and nine for follow-up post-Kasai.Estimated diagnostic odds ratio(DOR),sensitivity,and specificity of elastography were calculated through a random-effects model using Meta-DiSc software.RESULTS Mean liver stiffness in BA infants at diagnosis was significantly higher than in non-BA,with overall DOR 24.61,sensitivity 83%,and specificity 79%.Post-Kasai,mean liver stiffness was significantly higher in BA patients with varices than in patients without,with DOR 16.36,sensitivity 85%,and specificity 76%.Elastography differentiated stage F4 fibrosis from F0-F3 with DOR of 70.03,sensitivity 96%,and specificity 89%.Elastography also differentiated F3-F4 fibrosis from F0-F2 with DOR of 24.68,sensitivity 85%,and specificity 81%.CONCLUSION Elastography has potential as a non-invasive modality for BA diagnosis and surveillance post-Kasai.This paper’s limitations include inter-study method heterogeneity and small sample sizes.Future,standardized,multi-center studies are recommended. | Ellen S Wagner Hussien Ahmed H Abdelgawad Meghan Landry Belal Asfour Mark B Slidell Ruba Azzam | 2022 | World Journal of Gastroenterology2022，28，32： | 5 |
| 2 | Catabolism of Branched Chain Amino Acids Supports Respiration but Not Volatile Synthesis in Tomato Fruits显示文摘分支链氨基酸 transaminases (BCAT ) 在分支链氨基酸白氨酸,异白氨酸,和缬氨酸的新陈代谢有一个关键角色。这些酶催化合成的最后步和这些氨基酸的降级的起始的步。尽管在植物的分叉的链氨基酸的 biosynthetic 小径广泛地被调查了,很多基因被描绘了,他们在植物的分解代谢完全还没被理解。我们以前在西红柿描绘了分叉的链氨基酸 transaminase 基因家庭,揭示 subcellular 本地化和六基因编码的酶的运动性质。这里,我们在水果开发期间检验了酶的可能的功能。我们进一步描绘了在分叉的链氨基酸 transaminases 的表示不同的转基因的植物 1 和 3,在线 overexpressing 任何一个 BCAT1 或 BCAT3 在在 BCAT1 和 volatiles 的层次缺乏的水果评估呼吸的率。我们测试的份量上经由喂实验的先锋和同位素,在水果 volatiles 的形成的分叉的链氨基酸和他们的相应 keto 酸的重要性。我们的结果不仅第一次在水果呼吸表明分叉的链氨基酸的重要性,而且揭示那 keto 酸,而非氨基酸,是为分叉的链风味 volatiles 的可能的先锋。 | Andrej Kochevenko Wagner L. Araujo Gregory S. Maloney Denise M. Tieman Phuc Thi Do Mark G. Taylor Harry J. Klee Alisdair R. Fernie | 2012 | Molecular Plant2012，5，2： | 4 |
| 3 | Modeling carbon footprints across the supply chain显示文摘 | Balan Sundarakani Robert de Souza Mark Goh Stephan M. Wagner Sushmera Manikandan | 2010 | International Journal of Production Economics2010，，： | 2 |
| 4 | Erythropoietin attenuates the sequels of ischaemic spinal cord injury with enhanced recruitment of CD+34cellsin mice显示文摘 | Hirano K Wagner K Mark P | 2012 | J Cell Mol Med2012，16，8： | 1 |
| 5 | Mechanical properties of carbon nanoparticle reinforced elastomers显示文摘 | MARK D F DIANA R WAGNER H D | | 0，，11： | 1 |
| 6 | Biomechanical Analysis Comparing Titanium Elastic Nails With Locked Plating in Two Simulated Pediatric Femur Fracture Models显示文摘 | Scott E. Porter George R. Booker Douglas E. Parsell Mark D. Weber George V. Russell James Woodall Michael Wagner Thomas Neubauer | 2012 | Journal of Pediatric Orthopaedics2012，，6： | 1 |
| 7 | A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree显示文摘 | Kirsten M. Timms Susanne Wagner Mark E. Samuels Kristian Forbey Howard Goldfine Srikanth Jammulapati Mark H. Skolnick Paul N. Hopkins Steve C. Hunt Donna M. Shattuck | 2004 | Human Genetics2004，，： | 1 |
| 8 | Branched-chain amino acid interactions with reference to amino acid requirements in adult men:valine metabolism at different leucine intakes显示文摘 | Marks L Wagner DA | 1991 | Am J Clin Nutr1991，54，2： | 1 |
| 9 | Water distribution reliability: analytical methods显示文摘 | Wagner J M Shamir U Marks D H | 1988 | Journal of Water Resources Planning and Management1988，4，3： | 1 |
| 10 | Imitation Costs and Patents: An Empirical Study显示文摘 | Mansfield Edwin Mark Schwartz and Samuel Wagner | 1981 | Economic Journal1981，91，12： | 1 |
| 11 | Organ donation and utilization,1995-2004:entering the collaborative era显示文摘 | Marks WH Wagner D Pearson TC | 2006 | Am J Transplant2006，6，52： | 1 |
| 12 | Naturally Occurring and Experimental Diabetes in Cynomolgus Monkeys: A Comparison of Carbohydrate and Lipid Metabolism and Islet Pathology显示文摘 | Janice D Wagner J Mark Cline | 2001 | Toxicologic Pathology2001，9，1： | 1 |
| 13 | Water distribution reliability - simulation methods 显示文摘 | Wagner J M Shamir U Marks D H | 1988 | Journal of Water Resources Planning and Manage-ment1988，114，3： | 1 |
| 14 | Water distribution reliability: simulation methods 显示文摘 | Wagner J M Shamir U Marks D H | 1988 | Journal of Water Resources Planning and Management1988，114，3： | 1 |
| 15 | AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram显示文摘 | Galen S. Wagner Peter Macfarlane Hein Wellens Mark Josephson Anton Gorgels David M. Mirvis Olle Pahlm Borys Surawicz Paul Kligfield Rory Childers Leonard S. Gettes | 2009 | Journal of the American College of Cardiology2009，，11： | 1 |
| 16 | Water distribution reliability: simulation methods显示文摘 | Wagner J Shamir U Marks D | 1988 | Journal of Water Resources Planning and Management1988，114，3： | 1 |
| 17 | Visual Loss as a Complication of Spine Surgery: A Review of 37 Cases显示文摘 | Mark A. Myers Steven R. Hamilton Armen J. Bogosian Craig H. Smith Theodore A. Wagner | 1997 | Spine1997，，12： | 1 |
| 18 | Self-injury, Sexual Self-concept, and a Conservative Christian Upbringing: An Exploratory Study of Three Young Women’s Perspectives显示文摘 | Wagner Joyce Rehfuss Mark | 2008 | Journal of Mental Health Counseling2008，，2： | 1 |
| 19 | Mechanical Properties of Carbon Nanoparticle-reinforced Elastomers显示文摘 | Mark D Frogley Diana Ravich H Daniel Wagner | 2003 | Composites Science and Technology2003，63，11： | 1 |
| 20 | Imitation Costs and Patents: An Empirical Study 显示文摘 | Edwin Mansfield Mark Schwartz and Samuel Wagner | 1981 | The Economic Journal1981，91，： | 1 |
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