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| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 3 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 4 | MAP3Ks as central regulators of cell fate during development 显示文摘 | Evisabel A Craig Mark V Stevens Richard R Vaillancourt | 2008 | Developmental Dynamics2008，237，11： | 1 |
| 5 | Mapping and analysis of changes in the riparian landscape structure of the Lockyer Valley catchment Queensland, Australia显示文摘 | Armando A A Steven R R Mark S P | | Landscape and Urban Planning0，59，： | 1 |
| 6 | Pressurized liquid extraction using water/ isopropanol coupled with solid - phase extraction cleanup for semivolatile organic compounds, polycyclic aromatic hydrocarbons (PAH), and alkylated PAH homolog groups in sediment 显示文摘 | Mark R Steven D Teresa L | 2005 | Analytica Chimica Acta2005，549，： | 1 |
| 7 | Activation of innate immunity,inflammation,and potentiation of DNA vaccination through mammalian expression of the TLR5 agnnist Flagellin显示文摘 | Steven EA Erik R Mark DW | 2005 | J Immunol2005，175，6： | 1 |
| 8 | Within-stand spatial structure and relation of boreal canopy and understorey vegetation显示文摘 | Kembel Steven W Dale Mark R T | 2006 | Journal of Vegetation Science2006，17，： | 1 |
| 9 | Gene expression polymor- phisms and ESTs associated with gravitropic response of subterranean branch meristems and growth habit in Leymus wildryes]显示文摘 | Parminder K Ivan W M Steven R L Bushman B S Alvaro G H Kim W R Liu L Mark A M | 2008 | Plant Science2008，175，3： | 1 |
| 10 | The cost and effectiveness of solids thickening technologies for treating back- wash and recovering nutrients from intensive aquaculture systems显示文摘 | MARK J S KATA R STEVEN T S | 2010 | Bioresource Technology2010，101，： | 1 |
| 11 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 1 |
| 12 | Abundance, variability and chromosomal location of microsatellites in wheat显示文摘 | Marion S. R?der Jens Plaschke Susanne U. K?nig Andreas B?rner Mark E. Sorrells Steven D. Tanksley Martin W. Ganal | 1995 | MGG Molecular & General Genetics1995，，3： | 1 |
| 13 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 1 |
| 14 | Mapping and analysis of changes in the riparian landscape structure of the Lockyer Valley catchment Queensland, Australia 显示文摘 | Armando A A Steven R R Mark S P | 2002 | Landscape and Urban Planning2002，59，1： | 1 |
| 15 | Asymmetric synthesis of tetracyclic benz-o[a]quinolizidine targets显示文摘 | Steven M Allin Sean N Gaskell Mark R J Elsegood | | 0，，16： | 1 |
| 16 | Should We Test for CYP2C9 Before Initiating Anticoagulant Therapy in Patients with Atrial Fibrillation显示文摘 | Mark HE Steven MG Jonathan R | 2009 | Gen Intern Med2009，5，24： | 1 |
| 17 | Activated Kras,but not Hras or Nras,may initiate tumors of endodermal originvia stem cell expansion显示文摘 | Margaret P Steven E Mark R | 2008 | Mol Cell Biol2008，28，8： | 1 |
| 18 | Synthesis and properties of waterborne self-crosslinkable sulfo-urethane silanol dispersions 显示文摘 | Kevin Lewandowski Larry R Krepski Daniel E Mickus Ralph R Roberts Steven M Heilmann Wayne K Larson Mark D Purgett Steven D Koecher Stephen A Johnson Daniel J Mcgurran Chris J Rueb Sadanand V Pathre Khalid A M Thakur | 2002 | Journal of Polymer Science Part A : Polymer Chemistry2002，40，17： | 1 |
| 19 | The human drug metabolizing cytochromes P450显示文摘 | STEVEN A W MARK V B BARBARA J R | 1996 | J Pharmacokinet Biopharm1996，24，5： | 1 |
| 20 | Heterogeneous e xpression of connexins in rabbit sinoatrial node cells: correlation between connexin i- sotype and cell size显示文摘 | Haruo Honjo Mark R Boyet Steven R Coppen | 2002 | J Cardiovascular Research2002，53，1： | 1 |
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