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| 1 | Long noncoding RNAs:a missing link in osteoporosis显示文摘Osteoporosis is a systemic disease that results in loss of bone density and increased fracture risk,particularly in the vertebrae and the hip.This condition and associated morbidity and mortality increase with population ageing.Long noncoding(lnc)RNAs are transcripts longer than 200 nucleotides that are not translated into proteins,but play important regulatory roles in transcriptional and post-transcriptional regulation.Their contribution to disease onset and development is increasingly recognized.Herein,we present an integrative revision on the studies that implicate lncRNAs in osteoporosis and that support their potential use as therapeutic tools.Firstly,current evidence on lncRNAs involvement in cellular and molecular mechanisms linked to osteoporosis and its major complication,fragility fractures,is reviewed.We analyze evidence of their roles in osteogenesis,osteoclastogenesis,and bone fracture healing events from human and animal model studies.Secondly,the potential of lncRNAs alterations at genetic and transcriptomic level are discussed as osteoporosis risk factors and as new circulating biomarkers for diagnosis.Finally,we conclude debating the possibilities,persisting difficulties,and future prospects of using lncRNAs in the treatment of osteoporosis. | Andreia Machado Silva Sara Reis Moura JoseHenrique Teixeira Mario Adolfo Barbosa Susana Gomes Santos Maria Ines Almeida | 2019 | Bone Research2019，7，1： | 13 |
| 2 | Association between Helicobacterpylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas显示文摘AIM To correlate Helicobacter pylori(H. pylori), Epstein-Barr virus(EBV) and human papillomavirus(HPV) with gastric cancer(GC) cases in Pará State, Brazil.METHODS Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eber1 RNA was used to detect the presence of EBV in the samples, and the L1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for E6 and E7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the patients.RESULTS The majority of the 302 samples analyzed were obtained from men(65%) aged 55 years or older(67%) and were classified as the intestinal subtype(55%). All three pathogens were found in the samples analyzed in the present study(H. pylori : 87%, EBV: 20%, HPV: 3%). Overall, 78% of the H. pylori-positive(H. pylori+) samples were cag A +(H. pylori-cag A+), and there was an association between the cytotoxic product of this gene and EBV. Coinfections of H. pylori-cagA+ and EBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for EBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the E6 and E7 oncoproteins was detected. The fundus of the stomach was the region least affected by the pathogens.CONCLUSION HPV was not involved in gastric tumorigenesis. Prophylactic and therapeutic measures against H. pylori and EBV may prevent the development of GC, especially the more aggressive forms. | Carolina Rosal Teixeira de Souza Marcelli Carolini Alves Almeida Andre Salim Khayat Emerson Lucena da Silva Paulo Cardoso Soares Luiz Claudio Chaves Rommel Mario Rodriguez Burbano | 2018 | World Journal of Gastroenterology2018，24，43： | 6 |
| 3 | Fluoroquinolones for the treatment of latent Mycobacterium tuberculosis infection in liver transplantation显示文摘Solid organ transplantation(SOT)is the best treatment option for end-stage organ disease.Newer immunosuppressive agents have reduced the incidence of graft rejection but have increased the risk of infection,particularly due to the reactivation of latent infections due to opportunistic agents such as Mycobacterium tuberculosis.Active tuberculosis(TB)after SOT is a significant cause of morbidity and mortality.Most cases of posttransplant TB are secondary to reactivation of latent tuberculosis infection(LTBI)due to the effects of long-term immunosuppressive therapy.Risk minimization strategies have been developed to diagnose LTBI and initiate treatment prior to transplantation.Isoniazid with vitamin B6 supplementation is the treatment of choice.However,liver transplantation(LT)candidates and recipients have an increased risk of isoniazid-induced liver toxicity,leading to lower treatment completion rates than in other SOT populations.Fluoroquinolones(FQs)exhibit good in vitro antimycobacterial activity and a lower risk of drug-induced liver injury than isoniazid.In the present review,we highlight the disease burden posed by posttransplant TB and summarize the emerging clinical evidence supporting the use of FQs for the treatment of LTBI in LT recipients and candidates. | Jose Tiago Silva Rafael San-Juan Mario Fernández-Ruiz José María Aguado | 2019 | World Journal of Gastroenterology2019，25，26： | 5 |
| 4 | Transcriptome analyses of the Dof-like gene family in grapevine reveal its involvement in berry, flower and seed development显示文摘The Dof(DNA-binding with one finger)protein family spans a group of plant transcription factors involved in the regulation of several functions,such as plant responses to stress,hormones and light,phytochrome signaling and seed germination.Here we describe the Dof-like gene family in grapevine(Vitis vinifera L.),which consists of 25 genes coding for Dof.An extensive in silico characterization of the VviDofL gene family was performed.Additionally,the expression of the entire gene family was assessed in 54 grapevine tissues and organs using an integrated approach with microarray(cv Corvina)and real-time PCR(cv Pinot Noir)analyses.The phylogenetic analysis comparing grapevine sequences with those of Arabidopsis,tomato,poplar and already described Dof genes in other species allowed us to identify several duplicated genes.The diversification of grapevine DofL genes during evolution likely resulted in a broader range of biological roles.Furthermore,distinct expression patterns were identified between samples analyzed,corroborating such hypothesis.Our expression results indicate that several VviDofL genes perform their functional roles mainly during flower,berry and seed development,highlighting their importance for grapevine growth and production.The identification of similar expression profiles between both approaches strongly suggests that these genes have important regulatory roles that are evolutionally conserved between grapevine cvs Corvina and Pinot Noir. | Danielle Costenaro da Silva Vítor da Silveira Falavigna Marianna Fasoli Vanessa Buffon Diogo Denardi Porto Georgios Joannis Pappas Jr Mario Pezzotti Giancarlo Pasquali Luís Fernando Revers | 2016 | Horticulture Research2016，3，1： | 5 |
| 5 | Evidence of endometrial amino acid metabolism and transport modulation by peri-ovulatory endocrine profiles driving uterine receptivity显示文摘Background: In beef cattle, changes in the periovulatory endocrine milieu are associated with fertility and conceptus growth. A large preovulatory follicle(POF) and the resulting elevated concentrations of progesterone(P4) during diestrus positively affect pregnancy rates. Amino acids(AA) are important components of maternally derived secretions that are crucial for embryonic survival before implantation. The hypothesis is that the size of the POF and the concentration of P4 in early diestrus modulate the endometrial abundance of SLC transcripts related to AA transport and metabolism and subsequently impact luminal concentrations of AA. The follicle growth of Nelore cows was manipulated to produce two experimental groups: large POF and CL(LF-LCL group) and small POF and CL(SF-SCL group). On Day 4(D4; Experiment 1) and Day 7(D7; Experiment 2) after Gn RH-induced ovulation(Gn RH treatment = D0), the animals were slaughtered and uterine tissues and uterine washings were collected. q RT-PCR was used to evaluate the expression levels of AA transporters in D4 and D7 endometrial tissues.The concentrations of AA were quantified in D4 and D7 uterine washings by HPLC.Results: Transcript results show that, on D4, SLC6 A6, SLC7 A4, SLC17 A5, SLC38 A1, SLC38 A7 and SCLY and on D7 SLC1 A4, SLC6 A1, SLC6 A14, SLC7 A4, SLC7 A7, SLC7 A8, SLC17 A5, SLC38 A1, SLC38 A7, SLC43 A2 and DDO were more abundant in the endometria of cows from the LF-LCL group(P < 0.05). In addition, concentrations of AA in the uterine lumen were influenced by the endocrine profiles of the mother. In this context, D4 uterine washings revealed that greater concentrations of taurine, alanine and α-aminobutyric acid were present in SF-SCL(P < 0.05).In contrast, lower concentrations of valine and cystathionine were quantified on D7 uterine washings from SF-SCL cows(P < 0.05).Conclusion: The present study revealed an association between the abundance of transcripts related to AA transport and metabolism in the endometrium and specific periovulatory endocrine profiles related to the receptive status of the mother. Such insights suggest that AAs are involved in uterine function to support embryo development. | Moana Rodrigues Franca Maressa Izabel Santos da Silva Guilherme Pugliesi Veerle Van Hoeck Mario Binelli | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 4 |
| 6 | Multidetector Computed Tomographic Imaging in Chronic Obstructive Pulmonary Disease显示文摘 | Diana E. Litmanovich Kirsten Hartwick Mario Silva Alexander A. Bankier | 2014 | Radiologic Clinics of North America2014，，1： | 2 |
| 7 | Effect of rotary or manual instrumentation, with or without a calcium hydroxide 1% chlorhexidlne intracanal dressing,on the healing of experimentally induced chronic periapieal lesions 显示文摘 | ANDIARA DE ROSSI LE'A AB SILVA MARIO R LEOUARDO | 2005 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2005，99，5： | 1 |
| 8 | Novel design methodology and comparative analysis for ZVT PWM converters with resonant auxiliary circuit 显示文摘 | Mario Lucio da Silva Martins Jumar Luis Russi Helio Leaes Hey | 2006 | IEEE Transactions on Industry Applications2006，42，3： | 1 |
| 9 | Investigation of surface properties of Ru-based oxide electrodes containing Ti, Ce and Nb 显示文摘 | Mario H P Santana Leonardo M Da Silva Luiz A De Faria | 2003 | Electrochimica Acta2003，48，： | 1 |
| 10 | In vitro influence of temperature on the biological control activity of the fungus Duddingtonia flagrans against Haemonchus contortus in sheep显示文摘 | Rodrigo Buske Janio Morais Santurio Clarissa Vasconcelos Oliveira Liziane Aita Bianchini José Henrique Souza Silva Mario Luiz Rue | 2013 | Parasitology Research2013，，2： | 1 |
| 11 | Seismic performance of dual-steel moment resisting frames显示文摘 | Andre Tenchini Mario D’Aniello Carlos Rebelo Raffaele Landolfo Luis Sim?esda Silva Luciano Lima | 2014 | Journal of Constructional Steel Research2014，101，43： | 1 |
| 12 | Styrene epoxidation catalysed by manganese(III) salen complex supported on activated carbons显示文摘 | Mario Cardoso Ana Rosa Silva Baltazar de Castro | 2005 | Applied Catalysis A:General2005，285，： | 1 |
| 13 | 短跑运动员血浆中脑源性神经营养因子水平较普通人群显著升高(英文)显示文摘目的目前研究发现锻炼能增强健康人血液中脑源性神经营养因子(BDNF)的水平。BDNF水平的改变常发现于耐力运动而非力量锻炼。本研究旨在探讨厌氧型活动(如短跑)是否能改变人血浆中BDNF的浓度。方法对22名巴西100米短跑运动员,包括14名过去4年间参加过国际级奥林匹克及户外世锦赛的运动员(国际级)和8名只参加过本国比赛的运动员(国内级),以及15名此前从未参加过任何运动比赛的健康对照人群,用ELISA法检测其血浆中BDNF的水平。结果与对照组相比,国际级和国内级短跑运动员血浆中BDNF的水平均显著升高。此外,国际级短跑运动员血浆中BDNF的水平显著高于国内级运动员。结论血浆中BDNF水平的升高可能与运动加强有关。 | Paulo Roberto Correia Fulvio Alexandre Scorza Sérgio Gomes da Silva Aline Pansani Michelle Toscano-Silva Antonio Carlos de Almeida Ricardo Mario Arida | 2011 | Neuroscience Bulletin2011，27，5： | 1 |
| 14 | Effect of the Cymbopogon citratus , Maytenus ilicifolia and Baccharis genistelloides extracts against the stannous chloride oxidative damage in Escherichia coli显示文摘 | Suzana de F. Melo Scheila F Soares Rogério F da Costa Claudia R da Silva Marcia B.N de Oliveira Roberto J.A.C Bezerra Adriano Caldeira-de-Araújo Mario Bernardo-Filho | 2001 | MutRes-Genetic Toxicology and Environmental Mutagenesis2001，，1： | 1 |
| 15 | H2 Optimal Ripple - free Deadbeat Controller Design显示文摘 | Mario E Salgado Diego A Oyarzun Eduardo I Silva | 2007 | Automatica2007，43，： | 1 |
| 16 | Tumor necrosis factor-α and interleukin-6 expression in leukocytes and their association with polymorphisms and bone markers in diabetic individuals treated with pioglitazone显示文摘 | Silvia T. Himelfarb Fernanda A. Silva Simone S. Arazi Cristina M. Farjado Adriana Garofalo Marcelo C. Bertolami Adriana Bertolami Andre Faludi Marcelo F. Sampaio Adriana A. Rezende Rosario D.C. Hirata Mario H. Hirata | 2011 | Drug Metabolism and Drug Interactions2011，，1： | 1 |
| 17 | Raised C-Reactive Protein and Impaired Flow-Mediated Vasodilation Precede the Development of Preeclampsia显示文摘 | Ronald G. García Johanna Celedón Jesús Sierra-Laguado Miguel A. Alarcón Carlos Luengas Federico Silva Mario Arenas-Mantilla Patricio López-Jaramillo | 2007 | American Journal of Hypertension2007，，1： | 1 |
| 18 | Diagnosis of Helicobacter pylori Infection by Means of Reduced-Dose 13C-Urea Breath Test and Early Sampling of Exhaled Breath显示文摘 | Sylmara L.M. Pacheco Silvio K. Ogata Rodrigo S. Machado Francy Reis da Silva Patrício Mario L.E. Pardo Elisabete Kawakami | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，5： | 1 |
| 19 | Integrating species and successional classes for wood production in a mixed forest restoration system in a neotropical region显示文摘As forests in neotropical regions,particularly in developing countries,are devastated,interventions to restore biodiversity and its ecological functions are needed.Rural producers have thus been encouraged to grow trees for wood production as an economic activity.The objective of this study was to quantify the increment of wood density of four forest species from different successional classes of a mixed system of restoration in a neotropical forest in Brazil.Tree discs were sampled at breast height and analyzed radially by X-ray densitometry to obtain apparent density and basic density.Three trees each of a species from the pioneer,early and late secondary successional stages and of the dominant species in the climax community.The radial profiles indicated increasing density from the pith to bark of trunks,except for some variations due to wood defects and growth.Average density was 0.576 g cm^(-3),0.655 g cm^(-3),0.706 g cm^(-3)and 0.775 g cm^(-3),respectively,for Peltophorum dubium,Schinus terebinthifolius,Cariniana estrellensis and Hymenaea courbaril.Radial profiles indicated higher amplitudes in the apparent densities for slow-growing species.X-ray densitometry generated parameters such as minimum,average and maximum densities,and radial density variations.These parameters are important for understanding the ecological functional role of successional classes of the Atlantic Forest from the Neotropical region. | Ananias Francisco Dias Junior Ana Lucia Martins Sodero Pincelli Ana Paula Camara da Silva Alison Moreira da Silva Natalia Dias de Souza Mario Tommasiello Filho Jose Otavio Brito | 2021 | Journal of Forestry Research2021，32，6： | 1 |
| 20 | Escherichia coli strains from edema disease:O serogroups, and genes far Shiga toxin enterotoxins,and F18 fimbriae显示文摘 | ALex Souza da Silva Georgio Freesz Valadares Mario Paulo Amante Penatti | 2001 | Vet Microbiol2001，80，： | 1 |
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