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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | One-week dual therapy with ranitidine bismuth citrate and clarithromycin for the treatment of Helicobacter pylori infection in Brazilian patients with peptic ulcer显示文摘AIM: To assess the efficacy and safety of ranitidine bismuth citrate plus clarithromycin given for 1 wk in Brazilian patients with peptic ulcer.METHODS: One hundred and twenty patients with peptic ulcer were randomized in two treatment groups: (1) 1-wk regimen consisting of ranitidine bismuth citrate 400 mg b.i.d. with clarithromycin 500 mg b.i.d. or (2) 2-wk regimen of the same treatment. Eradication of the infection was considered when both the histologic examination and the urease test were negative for the infection 3 mo after treatment.RESULTS: By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively treated for 1 or 2 wk (P>0.05). By per protocol analysis, the eradication rates were 80% and 83%,respectively, in patients treated for 1 or 2 wk (P>0.05). Nine patients (8.2%) reported minor side effects. CONCLUSION: One-week therapy with ranitidine bismuth citrate and clarithromycin is safe, well tolerated and effective for treatment of H pylori infection, andappears to be comparable to the 2-wk regimen in terms of efficacy. | Maria Aparecida Mesquita S(o|^)nia Letícia Silva Lorena Jazon Romilson Souza Almeida Ciro Garcia Montes Fábio Guerrazzi Luciana T Campos José Murilo Rubiota Zeitune | 2005 | World Journal of Gastroenterology2005，11，23： | 1 |
| 3 | A genetic algorithm for solving a capacitated P - median problem 显示文摘 | ELON S C MARIA T A S ALEX A F | 2003 | Numeric Algorithm2003，35，4： | 1 |
| 4 | 显示文摘 | Tombak A Ayguavives F T Maria J P | 2000 | IEEE MTT-S Dig2000，，3： | 1 |
| 5 | Processof Lemongrass Essential oil: Physicochemical Characteriza-tion and Assessment Quality of the Distillate and the ResidueProducts 显示文摘 | LAURA P T GLAUCIA M F P MARIA R W | 2011 | Industrial & Engineering Chemistry Research2011，50，13： | 1 |
| 6 | The problem of assigning responsibility for greenhouse gas emissions 显示文摘 | Simone B Maria P F Enzo T | 2004 | Ecological Economics2004，，49： | 1 |
| 7 | Behavior of overhead transmission line parameters on the presence of ground wires显示文摘 | Srgio K Jos Pissolato F Maria Cristina T | 2005 | IEEE Trans on Power Delivery2005，20，2： | 1 |
| 8 | Heterogeneous Photocatalysis显示文摘 | Marye A F Maria T D | 1993 | Chem Rev1993，93，： | 1 |
| 9 | Extraction of lignin from sugar cane bagasse and Pinus taeda wood chips using ethanol-water mixture and carbon dioxide at high pressures显示文摘 | DANIEL P MARIA T B LUIZ h F | 2005 | The Journal of Supercritical Fluids2005，36，1： | 1 |
| 10 | Effect of physical training on exercise capacity,gas exchange and N-terminal probrain natriuretic peptide levels in patients with chronic heart failure显示文摘 | Maria Sarullo F Gristina T Brusca I | 2006 | Eur J Cardiovasc Prev Rehabil2006，13，5： | 1 |
| 11 | Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease显示文摘 | Christos M Papamichael John P Lekakis Kimon S Stamatelopoulos Theodoros G Papaioannou Maria K Alevizaki Adriana T Cimponeriu John E Kanakakis Aggeliki Papapanagiotou Anastasios Th Kalofoutis Stamatios F Stamatelopoulos | 2000 | The American Journal of Cardiology2000，，6： | 1 |
| 12 | Expression of Adhesion Molecules by Human Endothelial Cells Exposed to Oxidized Low Density Lipoprotein Influences of Degree of Oxidation and Location of Oxidized LDL显示文摘 | AKIRA T YAN H MARIA F | 2001 | Atherosclerosis2001，，154： | 1 |
| 13 | Does the Clam Ensis siliqua Provide Useful Information About Contamination by Polychlorinated Biphenyls and Organochlo~_ne Pesticides Beyond that of Mussel Mytilus galloprovincialis显示文摘 | Maria C F Maria T Ci Clara N | 2014 | Bulletin of Environmental Contamination and Toxicology2014，，92： | 1 |
| 14 | Study of Some Physical Properties of Biodegradable Films Based on Blends of Gelatin and Poly( vinyl alcohol) using a Response-surface Methodology显示文摘 | Carvalho R A Maria T M C Moraes I C F | 2009 | Materials Science and Engineering C2009，29，： | 1 |
| 15 | Protoplast formation and regeneration from Streptomyces clavuligerus NRRL 3585 and elavulanie acid production 显示文摘 | Maria das G C Jose L L F Galba M C T | 2002 | Brazilian Journal of Microbiology2002，33，： | 1 |
| 16 | Dendritic cells of immune thrombocytopenic purpura show increased capacity to present apoptotic platelet to T lymphocytes显示文摘 | CATANIL L MARIA E F PIER L T | 2006 | Experimental hematology2006，34，： | 1 |
| 17 | Protein degradation in C3 and C4 plants with particular reference to ribulose bisphosphate carboxylase and glycolate oxidase显示文摘 | MARIA G E RICARDO B F ARTUR R T | 1998 | Journal of Experimental Botany1998，49，： | 1 |
| 18 | Volt- age-Controlled RF Filters Employing Thin-Film Bari- um-Strontium-Titanate Tunable Capacitors 显示文摘 | Tombak A Maria J P Ayguavives F T | 2003 | IEEE Transactions on Microwave Theory and Techniques2003，51，： | 1 |
| 19 | Study of some physical proper- ties of biodegradable films based on blends of gelatin and poly( vinyl alcohol) using a response - surface methodology 显示文摘 | Carvalho R A Maria T M C Moraes I C F | 2009 | Materials Science and Engineering C2009，29，： | 1 |
| 20 | Heavy met als in stream sediments from copper and gold mining areas in southern Brazil显示文摘 | MARIA H D P MILTON L L F ELBA C T | 1997 | Journal of Geochemical Exploration1997，58，： | 1 |
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