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| 1 | Prevalence of Helicobacter pylori infection and intestinal metaplasia in subjects who had undergone surgery for gastric adenocarcinoma in Northwest Italy显示文摘AIM: To investigate the seroprevalence of Helicobacter pylori(H pylorri) infection and its more virulent strains as well as the correlation with the histologic features among patients who had undergone surgery for gastric cancer (GC).METHODS: Samples from 317 (184 males, 133females, mean age 69±3.4 years) consecutive patients who had undergone surgery for gastric non-cardia adenocarcinoma were included in the study. Five hundred and fifty-five (294 males, 261 females, mean age 57.3±4.1 years) patients consecutively admitted to the Emergency Care Unit served as control. Histological examination of tumor, lymph nodes and other tissues obtained at the time of surgery represented the diagnostic 'gold standard'. An enzyme immunosorbent assay was used to detect serum anti-H pylori(IgG)antibodies and Western blotting technique was utilized to search for anti-CagA protein (IgG).RESULTS: Two hundred and sixty-one of three hundred and seventeen (82.3%) GC patients and 314/555 (56.5%)controls were seropositive for anti-H pylori (P<0.0001;OR, 3.58; 95%CI, 2.53-5.07). Out of the 317 cases, 267(84.2%) were seropositive for anti-CagA antibody vs 100 out of 555 (18%) controls (P<0.0001; OR, 24.30;95%CI, 16.5-35.9). There was no difference between the frequency of H pyloriin intestinal type carcinoma (76.2%) and diffuse type cancer (78.8%). Intestinal metaplasia (IM) was more frequent but not significant in the intestinal type cancer (83.4% vs 75.2% in diffuse type and 72.5% in mixed type). Among the patients examined for IM, 39.8% had IM type Ⅰ, 8.3% type Ⅱ and 51.9% type Ⅲ (type Ⅲ vs others, P = 0.4).CONCLUSION; This study confirms a high seroprevalence of H pyloriinfection in patients suffering from gastric adenocarcinoma and provides further evidence that searching for CagA status over H pylori infection might confer additional benefit in identifying populations at greater risk for this tumor. | Giorgio Palestro Rinaldo Pellicano Gian Ruggero Fronda Guido Valente Marco De Giuli Tito Soldati Agostino Pugliese Stefano Taraglio Mauro Garino Donata Campra Miguel Angel Cutufia Elena Margaria Giancarlo Spinzi Aldo Ferrara Giorgio Marenco Mario Rizzetto Antonio Ponzetto | 2005 | World Journal of Gastroenterology2005，11，45： | 5 |
| 2 | Proliferative activity is asignificant prognostic factor in male breast carcinoma 显示文摘 | Pich A Margaria E Chinsa L | 1994 | Am J Pathol1994，145，： | 1 |
| 3 | Comparative study on joint data/pilot strategies for high sensitivity galileo E1 open service signal acquisition 显示文摘 | Ta T H Dovis F Margaria D | 2010 | IET Radar Sonar & Navigation2010，4，6： | 1 |
| 4 | Comparative study on joint data/pilot strategies for high sensitivity Galileo E1 open service signal acquisition 显示文摘 | TA T H DOVIS F MARGARIA D at al | 2010 | IET Radar Sonar & Navigation2010，4，6： | 1 |
| 5 | Theeffect of some drugs on the maximal capacity of athleticperformance in man显示文摘 | MARGARIA R AGHEMO P ROVELLI E | 1964 | Internationale Zeitschrift fürangewandte Physiologie einschlie-lich Arbeitsphysiologie1964，20，4： | 1 |
| 6 | Galileo AItBOC signal multiresotution acquisition strategy显示文摘 | Davide Margaria Fabio Dovis Paolo Mulassano | 2008 | IEEE A&E Systems Magazing2008，23，11： | 1 |
| 7 | Warmed-over flavour analysis in low temperature-long time processed meat by an 'electronic nose'显示文摘 | GRIGIONI G M MARGARIA C A PENSEL N A | 2000 | Meat Science2000，56，： | 1 |
| 8 | Indirect determination of maximal O2 consumption in man显示文摘 | Margaria R Aghemo P Rovelli E | 1965 | J Appl Physical1965，20，5： | 1 |
| 9 | Comparative study on jointdata/pilot strategies for high sensitivity Galileo E1 open servicesignal acquisition显示文摘 | Ta T H Dovis F Margaria D | 2010 | The Institution of Engineering andTechnology2010，4，6： | 1 |
| 10 | Assuring property con- formance of code generators via model checking 显示文摘 | Jorges S Margaria T Steffen B | 2011 | Formal Aspects of Computing2011，23，5： | 1 |
| 11 | Prognostic relevance of AgNORs in tumor pathology 显示文摘 | Pith A Chiusa L Margaria E | 2000 | Micron2000，31，2： | 1 |
| 12 | Differential al- gebra methods for the study of the structural identifiability of ra- tional function state-space models in the bioecience 显示文摘 | Margaria G Riccomagno E Chappell M J | 2001 | Mathe- matical Bioscience2001，174，： | 1 |
| 13 | Warmed- over favour analysis in low temperature-long time processed meat by an 'electronic nose' 显示文摘 | Grigioni G M Margaria C A Pesel N A | 2000 | Meat Science2000，56，3： | 1 |
| 14 | Proliferative activity is a significant prognostic factor in male breast carcinoma显示文摘 | Pich A Margaria E Chiusa L | 1994 | Am J Pathol1994，145，3： | 1 |
| 15 | Therapy and survival in male breast carcinoma: A retrospective analysis of 50 cases 显示文摘 | Margaria E Chiusa L Ferrari L | 2000 | Oncol Rep2000，7，5： | 1 |
| 16 | Acea program on the emissions of fine particulates from passenger cars (2) Part 1: Particle Characterization of a Wide Range of Engine Technologies显示文摘 | MOHR M LEHMANN U MARGARIA G | 2003 | SAE Paper2003，，： | 1 |
| 17 | Warmedover flavour analysis in low temperature-long time processed meat by an 'electronic nose '显示文摘 | GRIGIONI G M MARGARIA C A PENSEL N A | 2000 | Meat Science2000，56，3： | 1 |
| 18 | Assuring property conformance of code generators via model checking 显示文摘 | Jorges S Margaria T Steffen B | 2011 | Formal Aspects of Computing2011，23，5： | 1 |
| 19 | Analysis of recovery from anaerobic work显示文摘 | D. B. Dill H. T. Edwards E. V. Newman R. Margaria | 1936 | Arbeitsphysiologie1936，，3： | 1 |
| 20 | Warmed-over flavour analysis in low temperaturelong time processed meat by an 'electronic nose'显示文摘 | Gabriela M Grigioni Carlos A Margaria Norma A Pensel | 2000 | Meat Science2000，56，： | 1 |
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