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| 1 | Pyrrolidine dithiocarbamate reduces ischemia-reperfusion injury of the small intestine显示文摘AIM: To evaluate whether pyrrolidine dithiocarbamate (PDTC), an enhancer of HO production, attenuates intestinal IR injury.METHODS: Eighteen male rats were randomly allocated into three groups: (a) sham; (b) IR, consisting of 30 min of intestinal ischemia, followed by 2-h period of reperfusion; and (c) PDTC treatment before IR. Intestinal microvascular perfusion (IMP) was monitored continuously by laser Doppler fiowmetry. At the end of the reperfusion, serum samples for lactate dehydrogenase (LDH) levels and biopsies of ileum were obtained. HO activity in the ileum was assessed at the end of the reperfusion period.RESULTS: At the end of the reperfusion in the IR group,IMP recovered partially to 42.5% of baseline (P<0.05vs sham), whereas PDTC improved IMP to 67.3% of baseline (P<0.01 vs IR). There was a twofold increase in HO activity in PDTC group (2 062.66±106.11) as compared to IR (842.3±85.12) (P<0.001). LDH was significantly reduced (P<0.001) in PDTC group (585.6±102.4)as compared to IR group (1 973.8±306.5). Histological examination showed that the ileal mucosa was significantly less injured in PDTC group as compared with IR group.CONCLUSION: Our study demonstrates that PDTC improves the IMP and attenuates IR injury of the intestine possibly via HO production. Additional studies are warranted to evaluate the clinical efficacy of PDTC in the prevention of IR injury of the small intestine. | Ismail H Mallick Wen-Xuan Yang Marc C Winslet Alexander M Seifalian | 2005 | World Journal of Gastroenterology2005，11，46： | 8 |
| 2 | Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography–mass spectrometry显示文摘 | Michel Y Haller Stephan R Müller Christa S McArdell Alfredo C Alder Marc J.-F Suter | 2002 | Journal of Chromatography A2002，，1： | 2 |
| 3 | Helicobacer pylori initiate or perpetuate immune thrombocytopenic purpura? 显示文摘 | Marc M Nichola C Christelle J | 2004 | Blood2004，103，3： | 1 |
| 4 | Intermittent antegrade tep id versus cold blood cardioplegia in elective myocardial revascularization显示文摘 | Andrew C Fiore M D Marc T | 1998 | Ann Thorac Surg1998，65，： | 1 |
| 5 | Cell cycle arrest and proapoptotic effects of the anticancer cyclodep-sipeptide serratamolide(AT514)are independent of p53 status in breast cancer cells显示文摘 | Vanessa S C Beatriz M Marc M | 2005 | Biochemical pharmacology2005，71，12： | 1 |
| 6 | Synthesis, characterization, and magnetic properties of dendrimer-encapsulated nickel nanoparticles containing <150 atoms显示文摘 | Marc R K Joaquin C Richard M C | 2006 | Chem Mater2006，18，21： | 1 |
| 7 | Growth and dry mass partitioning in tomato as affected by phosphorus nutrition and light显示文摘 | DE GROOT C C MARCELIS L F M VAN DEN BOOGAARD R | 2001 | Plant Cell & Environment2001，24，： | 1 |
| 8 | Computer modeling and intraoperative navigation in maxillofacial surgery 显示文摘 | Annette M Pham Amir A Rafii Marc C | 2007 | Otolaryngology-Head and Neck Surgery (S1043-1810)2007，137，4： | 1 |
| 9 | The TIMI risk score for unstable angina/non ST elevation MI: A method for prognostication and therapeutic decision making显示文摘 | Elliott M Marc C Peter J | 2000 | JAMA2000，284，8： | 1 |
| 10 | Ultrasound of the knee with emphasis on the detailed anatomy of anterior, medial, and lateral structures显示文摘 | De Maeseneer M Marcelis S Boulet C | 2014 | Skeletal Radio12014，43，8： | 1 |
| 11 | Oxygen optrode for use in a fiber optic glucose biosensor 显示文摘 | MORENO - BONDI M C WOLFBEIS O S MARC J P | 1990 | Anal Chem1990，62，21： | 1 |
| 12 | Growth and drymass partitioning in tomato as affected by phosphorus nutrition and light 显示文摘 | de Groot C C Marcelis L F M van den Boogaard R | 2001 | Plant Cell Environ2001，24，： | 1 |
| 13 | The Dioscorea genus: a review of bioactive steroid saponins显示文摘 | Marc S Anne C M Marie A L | 2007 | J Nat Med2007，，61： | 1 |
| 14 | SJES14110700138146显示文摘 | Michael Manns Stanislas Pol Ira M Jacobson Patrick Marcellin Stuart C Gordon Cheng-Yuan Peng Ting-Tsung Chang Gregory T Everson Jeong Heo Guido Gerken Boris Yoffe William J Towner Marc Bourliere Sophie Metivier Chi-Jen Chu William Sievert Jean-Pierre Bron | 2014 | The Lancet2014，，9954： | 1 |
| 15 | Interaction of nitrogen and phosphorus nutrition in determining growth显示文摘 | De Groot C C Marcelis L F M Van den Boogaard R | 2003 | Plant Soil2003，248，： | 1 |
| 16 | Analysis of Groundwater' Resource Decline in an Intermountain Aquifer System in Central Iran显示文摘 | Marc V C Mahdi R Kristine M | | Geologica Belgica0，15，3： | 1 |
| 17 | Why do employees take more initiatives to improve their performance after co-deveh)ping performance measures? A field study显示文摘 | Bianca A C Marc J F Celeste P M | 2012 | Management ccounting Resem''ch2012，23，2： | 1 |
| 18 | Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production显示文摘 | Bert K Lopansri Nicholas M Anstey J Brice Weinberg Gregory J Stoddard Maurine R Hobbs Marc C Levesque Esther D Mwaikambo Donald L Granger | 2003 | The Lancet2003，，9358： | 1 |
| 19 | Interaction of nitrogen and phosphorus nutrition in determin- ing growth显示文摘 | De Groot C C Marcelis L F M Van Den Roogaard R | 2003 | Plant and Soil2003，248，12： | 1 |
| 20 | A nonlinearleast-squares approach for identification of the inductionmotor parameters显示文摘 | Wang K Y John C Marc B Leon M T | 2005 | IEEE Transactions on AutomaticControl2005，50，10： | 1 |
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