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| 1 | Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)represents a global health problem.Infections with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this tumor.Regardless of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis.Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence motifs.Here,we summarize the current literature implicating galectins in the pathogenesis of HCC.Expression of'proto-type'galectin-1,'chimera-type'galectin-3 and'tandem repeat-type'galectin-4 is up-regulated in HCC cells compared to their normal counterparts.On the other hand,the'tandemrepeat-type'lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes.The abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor prognosis.Moreover,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take place.Galectin-based therapies have been proposed to attenuate liver pathologies.Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC. | María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F Troncoso | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 2 | Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department显示文摘 | Agrawal D Manzi S F Gupta R | 2003 | Ann Emerg Med2003，42，5： | 1 |
| 3 | Prevalence and risk factors of carotid plaque in women with systemic lupus erythematosus显示文摘 | Manzi S Selzer F Sutton-Tyrrell K | 1999 | Arthritis Rheum1999，42，1： | 1 |
| 4 | Effect of intermittent PTH administration in the periodontitis-associated bone loss in ovariectomized rats显示文摘 | MARQUES M R SILVA M A D MANZI F R | 2005 | Arch Oral Biol2005，50，4： | 1 |
| 5 | Prevalence and risk factors of carotid plaque in women with systemic lupus erythematosus 显示文摘 | Manzi S Seizer F Sutton-Tyrrel K | 1999 | Arthritis Rheu1999，42，： | 1 |
| 6 | Suboptimal cold start strategies for spank ignition engines显示文摘 | Keynejad F Manzie C | 2013 | IEEE Transactions on Control Systems Technology2013，21，4： | 1 |
| 7 | Association study of Toll-like receptor 5 ( TLR5 ) and Toll-like receptor 9 ( TLR9 ) pol- ymorphisms in systemic lupus erythematosus 显示文摘 | Demirci F Y Manzi S Ramsey-Goldman R | 2007 | J Rheumatol2007，34，8： | 1 |
| 8 | Adaptive brake torque variation compensation for an electromechanical brake 显示文摘 | LEE C F MANZIE C | 2012 | SAE International Journal of Passenger Cars-Electronic and Electrical Systems2012，5，2： | 1 |
| 9 | Preprocedural fasting state and adverse events in children undergo- ing procedural sedation and analgesia in a pediatric e- mergency department 显示文摘 | Agrawal D Manzi S F Gupta R | 2003 | Ann Emerg Med2003，42，5： | 1 |
| 10 | Relationship between endurance field tests and match performance in young soccer players 显示文摘 | Castagna C Manzi V Impellizzeri F Weston M Barbero A1- varez J C | 2010 | J Strength Cond Res2010，24，12： | 1 |
| 11 | A re-appraisal of Ceprano calvaria affinities with Homo erectus after the new reconstruction显示文摘 | Ascenzi A Mallegni F Manzi G | 2000 | Journal of Human Evolution2000，39，： | 1 |
| 12 | Aircraft wake detection using bistatic radar: analysis of experimental results显示文摘 | IANNUZZELLI R J SCHEMM C E MARCOTTE F J MANZI L P | 1998 | Johns Hopkins APL Technical Digest1998，19，3： | 1 |
| 13 | Solid-state 13 C-NMR spectroscopy of mushrooms gives directly the ratio be- tween proteins and polysaceharides 显示文摘 | PIZZOFERRATO L MANZI P BERTOCCHI F | 2000 | J Agric Food Chem2000，48，11： | 1 |
| 14 | Deep-water clastic evaporites deposition in the Messinian Adriatic foredeep (northern Apennines,Italy):did the Mediterranean ever dry out?显示文摘 | Manzi V Lugli S Lucchi F R | 2005 | Sedimentology2005，52，4： | 1 |
| 15 | The land surface scheme ISBA with the Meteo-France climate model ARPEGE, I, Implenentation and preliminary results显示文摘 | Mahfouf J F A O Manzi J Noilhan | 1995 | J Climate1995，8，： | 1 |
| 16 | Role of an intronic polymorphism in the PDCD1 gene with the risk of sporadic systemic lupus erythematosus and the occurrence of antiphospholipid anti-bodies显示文摘 | Sanghera DK Manzi S Bontempo F | 2004 | J Hum Genet2004，115，5： | 1 |
| 17 | Analysis of the self-discharge process in Li Co PO4 electrodes:Bulks显示文摘 | Manzi J Vitucci F M Paolone A | 2015 | Electrochimica Acta2015，179，： | 1 |
| 18 | Effect of Inter- mittent PTH Adnfirtistration in the Periodontitis-Associated l:ne Ia:ss in Ovariectomized Rats显示文摘 | Marques M R da Silva M A Manzi F R | 2005 | Archives of Oral Biolo- g3''2005，50，4： | 1 |
| 19 | Association of a common inter- femn regulatory factor 5 (IRF5)variant with increased risk of systemic lu- pus erythem-atusus ( SLE ) 显示文摘 | Demirci F Y Manzi S Ramsey-Goldman R | 2007 | Ann Hum Genet2007，71，3： | 1 |
| 20 | Unprocedural Fasting State and Adverse Events in Children Undergoing Procedu- ral Sedation and Analgesia in a Pediatric Emergency De- partment显示文摘 | Agrawal D Manzi S F Gupta R | 2003 | Ann Emerg Med2003，，42： | 1 |
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