|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | Molecular Characterization of the Arabidopsis Floral Homeotic Gene APETALAI显示文摘 | Mandel M Gustason Brown C Savidge B | 1992 | Nature1992，360，： | 1 |
| 3 | Independence fringes produced by superposition independent maser light beams显示文摘 | Magyar B G Mandel Dr L | 1963 | Nature1963，，4877： | 1 |
| 4 | Covering models for two-tiered emergency medical service systems显示文摘 | Marvin B Mandell | 1998 | Location Science1998，6，： | 1 |
| 5 | Effects of carcass weight class and postmortem aging on carcass characteristics and sensory at- tributes in grain-fed veal显示文摘 | Mandell I B Maclaurin T Buttenhan S | 2001 | Food Sci2001，66，5： | 1 |
| 6 | Molecu- lar characterization of the Arabidopsis floral homeotic gene APETELA1 显示文摘 | Mandel M A Gustafson-Brown C Savidge B | 1992 | Nature1992，360，6401： | 1 |
| 7 | Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho related signaling 显示文摘 | Babbin B A Parkos C A Mandell K J | 2007 | The American Journal of Pathology2007，170，95： | 1 |
| 8 | Certain special features of the formation of welds made at high speeds显示文摘 | PATON E O MANDEL' BERG S L Sidorenko B G | 1971 | Autom Weld1971，24，8： | 1 |
| 9 | Differential diagnoses and therapy显示文摘 | MANDELL B F LIPANI J Refractory osteoarthritis | 1995 | Rheum Dis Clin North Am1995，21，： | 1 |
| 10 | Modeling effectiveness-equity trade-offs in public service delivery systems显示文摘 | Mandell M B | | 0，，04： | 1 |
| 11 | Some long - run properties of geophysical records显示文摘 | Mandel Brot B B Wallis J R | 1969 | Water Resource Research1969，5，2： | 1 |
| 12 | Molecular characterization of the Arabidopsis floral homeotic-gene, APETALA1 显示文摘 | Mandel M A Gustafson-Brown C Savidge B | 1992 | Nature1992，360，6401： | 1 |
| 13 | Molecular characterization of the Arabidopsis floral homeotic gene APETALAI显示文摘 | Aleiandra Mandel M Gustafson-Brown C Savidge B | 1992 | Nature1992，360，： | 1 |
| 14 | Road transport conditions of slaughter cattle: Effects on the prevalence of dark, firm and dry beef显示文摘 | WARREN L A MANDELL I B BATEMAN K G | 2010 | Canadian Journal of Animal Science2010，90，4： | 1 |
| 15 | Frequency of symptoms of ovarian cancer in women presenting to primary care clinics 显示文摘 | Goff B A Mandel L S Melancon C H | 2004 | JAMA2004，291，22： | 1 |
| 16 | Molecular Characterization of the Arabidopsis Floral Homeotic Gene APETALAI显示文摘 | MANDEL M GUSTAFSON BROWN C SAVIDGE B et a l | 1992 | Nature1992，360，27： | 1 |
| 17 | Biomonitoring of 2,4-dichlorophenoxyacetic acid exposure and dose in farm families 显示文摘 | ALEXANDER B H MANDEL J S BAKER B A | 2007 | Environ Health Perspect2007，115，3： | 1 |
| 18 | Synthesis and spectroscopic characterization of cobalt(Ⅲ) and copper(Ⅱ) comple- xes of hexadentate and tetradentate ligands containing pyridyl arms 显示文摘 | Jeffrey B Mandel Chris Maricondi Bodie E Douglas | 1988 | Inorganic Chemistry1988，27，17： | 1 |
| 19 | Activated protein C resistance can be associated with recurrent fetal loss显示文摘 | MANDEL H LANIR N | 1997 | Br J Haematol1997，97，3： | 1 |
| 20 | Refractory osteoarthritis Differentialdiagno- sis and therapy显示文摘 | MANDELL B F LIPAAI J | 1995 | Rheum Dis Clin North Am1995，21，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员