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| 1 | ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis显示文摘Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute stroke.We studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery stenosis.Participants and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SEM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CEA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent CEA.Data were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)curves.Results:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥4.There was no significant difference in the NICE red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score was<4 in 27 of 86(31% :95% CI 21 to 41)embolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral microemboli.After adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery stenosis.On the basis of NICE guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treatment in many patients. | Mahmud Saedon Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2017 | Stroke & Vascular Neurology2017，2，2： | 6 |
| 2 | Imaging vulnerable plaque by ultrasound显示文摘 | Demaria AN Narula J Mahmud E | 2006 | J Am Coll Cardiol2006，47，： | 1 |
| 3 | Numerical Simulation of Turbulent Batch Mixing in a Vessel Agi-tated by A Rushton Turbine显示文摘 | Jaced K H Mahmud T Zhu J M | | 0，，02： | 1 |
| 4 | Arterial stiffness is related to system- ic inflammation in essential hypertension 显示文摘 | Mahmud A Feely J | 2005 | Hyperten- sion2005，46，5： | 1 |
| 5 | Performance testing of a counter-cross-flow run-around membrane energy exchanger (RAMEE) system for HVAC applications显示文摘 | Mahmud K Mahmood G I Simonson C J | 2010 | Energy and Buildings2010，42，7： | 1 |
| 6 | Biosyn thesis of the validamycins :identification of intermediates in the biosyn thesis of validamycin a by streptomyces hygro scopicus var limoneus显示文摘 | DONG H J MAHMUD T TORNUS I | 2001 | J Am Chem Soc2001，123，： | 1 |
| 7 | Adiponectin and arterial stiffness显示文摘 | Feely J | 2005 | Am J Hypertens2005，18，121： | 1 |
| 8 | Circadian blood pressure variation : relationship between dipper status and measure of arte- rial stiffness显示文摘 | Jerrard-Dunne P Mahmud A Feely J | 2007 | J Hypertens2007，25，6： | 1 |
| 9 | Robust partial feedback linearizing stabilization scheme for three-phase grid-connected photovoltaic systems显示文摘 | Mahmud M A Pota H R Hossain M J | 2014 | IEEE Journal of Photovoltaics2014，4，1： | 1 |
| 10 | Artefial stiffness is related to systemic inflammation in essential hypertension显示文摘 | Mahmud A Feely J | 2005 | Hypertension2005，46，5： | 1 |
| 11 | Numerical simulation of turbulent batch mixing in a vessel agitated by a Rushton turbine 显示文摘 | JAVED K H MAHMUD T ZHU J M | 2006 | Chemical Engineering and Processing2006，45，： | 1 |
| 12 | IL-2,-7,and-15,but not thymic stromal lymphopoeitin,redundantly govern CD4+Foxp3+regulatory T cell development显示文摘 | Vang KB Yang J Mahmud SA | 2008 | J Immunol2008，181，5： | 1 |
| 13 | Beta-blockers reduce aortic stiffness in hypertension but neblvolol, not atenolol, reduces wave reflection 显示文摘 | Mahmud A Fecly J | 2008 | Am J Hypertens2008，21，6： | 1 |
| 14 | Arterial stiffness is retated to systemic inflammation in essential hypertension显示文摘 | Mahmud A Feely J | | 0，，05： | 1 |
| 15 | Circadian blood pressure variation:relationship between dipper status and measures of arterial stiffness显示文摘 | Jerrard-Dunne P Mahmud A Feely J | 2007 | J Hypertens2007，25，： | 1 |
| 16 | Circadian blood pressure varia-tion relationship between dipper status and measures of arterialstiffness显示文摘 | Jerrard P Mahmud A Feely J | 2007 | J Hypertens2007，25，3： | 1 |
| 17 | Imaging vulnerable plaque by ultrasound显示文摘 | DeMaria AN Narula J Mahmud E | 2006 | J Am Coil Cardiol2006，47，8： | 1 |
| 18 | Type 2 diabetes in children and adolescents显示文摘 | Amed S Daneman D Mahmud FH Hamilton J | 2010 | Expert Rev Cardiovasc Ther2010，8，3： | 1 |
| 19 | Reactions of carbonyl sulfide and methyl mercaption with ethanolamines显示文摘 | Mahmud A Rabman Robert N Maddox G J Mains | 1989 | Ind Eng Chem Res1989，28，4： | 1 |
| 20 | Arterial stiffness is related to systemic inflammation in essential hypertension 显示文摘 | MAHMUD A FEELY J | 2005 | Hypertension2005，46，5： | 1 |
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