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| 1 | Pancreatic injury in patients with septic shock: A literature review显示文摘Sepsis and septic shock are life threatening condition associated with high mortality rate in critically-ill patients. This high mortality is mainly related to the inadequacy between oxygen delivery and cellular demand leading to the onset of multiorgan dysfunction. Whether this multiorgan failure affect the pancreas is not fully investigated. In fact, pancreatic injury may occur because of ischemia, overwhelming inflammatory response, oxidative stress, cellular apoptosis and/or metabolic derangement. Increased serum amylase and/or lipase levels are common in patients with septic shock. However, imaging test rarely reveal significant pancreatic damage. Whether pancreatic dysfunction does affect the prognosis of patients with septic shock or not is still a matter of debate. In fact, only few studies with limited sample size assessed the clinical relevance of the pancreatic injury in this group of patients. In this review, we aimed to describe the epidemiology and the physiopathology of pancreatic injury in septic shock patients, to clarify whether it requires specific management and to assess its prognostic value. Our main finding is that pancreatic injury does not significantly affect the outcome in septic shock patients. Hence, increased serum pancreatic enzymes without clinical features of acute pancreatitis do not require further imaging investigations and specific therapeutic intervention. | Anis Chaari Karim Abdel Hakim Kamel Bousselmi Mahmoud Etman Mohamed El Bahr Ahmed El Saka Eman Hamza Mohamed Ismail Elsayed Mahmoud Khalil Vipin Kauts William Francis Casey | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 8 |
| 2 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 3 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 4 | Pancreatic pseudocyst or a cystic tumor of the pancreas?显示文摘Pancreatic pseudocysts are the most common cystic lesions of the pancreas and may complicate acute pancreatitis, chronic pancreatitis, or pancreatic trauma. While the majority of acute pseudocysts resolve spontaneously, few may require drainage. On the other hand, pancreatic cystic tumors, which usually require extirpation, may disguise as pseudocysts. Hence, the distinction between the two entities is crucial for a successful outcome. We conducted this study to highlight the fundamental differences between pancreatic pseudocysts and cystic tumors so that relevant management plans can be devised. We reviewed the data of patients with pancreatic cystic lesions that underwent intervention between June 2007 and December 2010 in our hospital. We identified 9 patients(5 males and 4 females) with a median age of 40 years(range, 30–70 years). Five patients had pseudocysts, 2 had cystic tumors, and 2 had diseases of undetermined pathology. Pancreatic pseudocysts were treated by pseudocystogastrostomy in 2 cases and percutaneous drainage in 3 cases. One case recurred after percutaneous drainage and required pseudocystogastrostomy. The true pancreatic cysts were serous cystadenoma, which was treated by distal pancreatectomy, and mucinous cystadenocarcinoma, which was initially treated by drainage, like a pseudocyst, and then by distal pancreatectomy when its true nature was revealed. We conclude that every effort should be exerted to distinguish between pancreatic pseudocysts and cystic tumors of the pancreas to avoid the serious misjudgement of draining rather than extirpating a pancreatic cystic tumor. Additionally, percutaneous drainage of a pancreatic pseudocyst is a useful adjunct that may substitute for surgical drainage. | Mohammad Ezzedien Rabie Ismail El Hakeem Mohammad Saad Al Skaini Ahmad El Hadad Salim Jamil Mian Tahir Shah Mahmoud Obaid | 2014 | Chinese Journal of Cancer2014，33，2： | 2 |
| 5 | Passivity and passification of time-delay systems显示文摘 | Mahmoud M S Ismail A | 2004 | J Math Anal Appl2004，292，1： | 1 |
| 6 | BIRC6/ Apollon gene expression in childhood acute leukemia: impact on therapeutic response and prognosis 显示文摘 | Ismail EA Mahmoud HM Tawfik LM | 2012 | Haematol2012，88，2： | 1 |
| 7 | BIRC6/Apollon gene expression in childhood acute leukemia: impact on therapeutic response and prognosis显示文摘 | ISMAIL E A MAHMOUD H M TAWFIK L M | 2012 | fur J Haematol2012，88，2： | 1 |
| 8 | Profitability analysis of a femtosecond laser system for cataract surgery using a fuzzy logic approach显示文摘AIM:To define the financial and management conditions required to introduce a femtosecond laser system for cataract surgery in a clinic using a fuzzy logic approach.METHODS:In the simulation performed in the current study,the costs associated to the acquisition and use of a commercially available femtosecond laser platform for cataract surgery(VICTUS,TECHNOLAS Perfect Vision GmbH,Bausch & Lomb,Munich,Germany) during a period of 5y were considered.A sensitivity analysis was performed considering such costs and the countable amortization of the system during this 5y period.Furthermore,a fuzzy logic analysis was used to obtain an estimation of the money income associated to each femtosecond laser-assisted cataract surgery(G). RESULTS:According to the sensitivity analysis,the femtosecond laser system under evaluation can be profitable if 1400 cataract surgeries are performed per year and if each surgery can be invoiced more than $500.In contrast,the fuzzy logic analysis confirmed that the patient had to pay more per surgery,between $661.8 and $667.4 per surgery,without considering the cost of the intraocular lens(IOL).CONCLUSION:A profitability of femtosecond laser systems for cataract surgery can be obtained after a detailed financial analysis,especially in those centers with large volumes of patients.The cost of the surgery for patients should be adapted to the real flow of patients with the ability of paying a reasonable range of cost. | Jose Antonio Trigueros David P Pinero Mahmoud M Ismail | 2016 | International Journal of Ophthalmology(English edition)2016，9，7： | 1 |
| 9 | Robust Kalman filtering for discrete-time Markovian jump systems with parameter uncertainty显示文摘 | MAHMOUD M S SHI P ISMAIL A | 2004 | Journal of Computational and Applied Mathematics2004，169，： | 1 |
| 10 | Hotspot mutations of PIK3CA and AKTI genes are absent in multiple myeloma显示文摘 | ISMAIL S I MAHMOUD I S MSALLAM M M | 2010 | Leuk Res2010，34，6： | 1 |
| 11 | BIRC6/apollon gene expression in childhood acute leukemia:impact on therapeutic response and prognosis显示文摘 | Ismail EA Mahmoud HM Tawfik LM | | 0，，02： | 1 |
| 12 | Robust adaptive control of uncertain discrete-time state-delay systems 显示文摘 | Mahmoud M S Boukas E Ismail A | 2008 | Computers & Mathematics with Applications2008，55，12： | 1 |
| 13 | A uni- fied approach for the optimal PMU location for pow- er system state estimation显示文摘 | Abbasy Nabil H Ismail Hanafy Mahmoud | 2009 | IEEE Trans on Power Systems2009，24，2： | 1 |
| 14 | Hotspot mutations of PIK3 CA and AKT1 genes are absent in multiple myeloma显示文摘 | Ismail S I Mahmoud I S Msallam M M Sughayer M A | 2010 | Leuk Res2010，34，6： | 1 |
| 15 | Null Steering in phased Arrays by Controlling the Element Positions 显示文摘 | T H Ismail Mahmoud M Dawoud | 1991 | IEEE Trans AP1991，39，11： | 1 |
| 16 | BIRC6/Apollon gene ex- pression in childhood aeute leukemia: impact on therapeutic re- sponse and prognosis显示文摘 | Abdel E Ismail R Mahmoud HM | 2012 | haematology2012，88，2： | 1 |
| 17 | Robust Kalman filtering for discrete-time Markovian jump systems with parameter uneertainty显示文摘 | Mahmoud M S Shi P Ismail A | 2004 | Journal of Computational and Applied Mathematics2004，169，1： | 1 |
| 18 | A unified approach for the optimal PMU locationfor power system state estimation 显示文摘 | Nabil H Abbasy Hanafy Mahmoud Ismail | 2009 | IEEE Transactions on Power Systems2009，24，2： | 1 |
| 19 | Null Steering in phased Arrays by Controlling the Element Positions显示文摘 | T H Ismail Mahmoud M Dawoud | 1991 | IEEE Trans AP1991，39，11： | 1 |
| 20 | Design and analysis of planar phased MIMO antenna for radar applications 显示文摘 | ISMAIL N E D MAHMOUD S H HAMED A | 2014 | Session 3P02014，，： | 1 |
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