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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | The role of chemokine receptors in primary effector and memory immune responses显示文摘 | Sallusto F Mackay C R Lanzavecchia A | | 0，，： | 3 |
| 3 | Reverse micellar synthesis of a nanoparticle/polymer composite 显示文摘 | Pavel F M Mackay R A | 2000 | Langmuir2000，16，23： | 1 |
| 4 | Modeling tetracycline antibiotic sorption to clays显示文摘 | Figueroa R A Leonard A MacKay A A | 2003 | Environmental Science & Technology2003，38，2： | 1 |
| 5 | identification of the 72- kDa(MMP - 2)and 92 - kDa(MMP - 9)gelatinase type iv collar - genase in preparations of laminin and Matrigel 显示文摘 | Mackay A R Gomez D E Cottam D W | 1993 | Biotech - niques1993，15，： | 1 |
| 6 | Modeling tetracycline antibiotic sorotion to clays显示文摘 | Figueroa R A Leonard A MacKay A A | 2004 | Environ Sci Technol2004，38，2： | 1 |
| 7 | Sorption of oxytetracycline to iron oxides and iron oxide-rich soils显示文摘 | Figueroa R A MacKay A A | 2005 | Environmental Science & Technology2005，39，17： | 1 |
| 8 | The role of chemo- kine receptors in primary, effector, and memory immune re- sponses 显示文摘 | Sallusto F Mackay C R Lanzaveechia A | 2000 | Annu Rev Immunol2000，18，： | 1 |
| 9 | Urban groundwater base- flow influence upon inorganic river-water quality: the river tame headwaters catchment in the city of Birmingham, UK 显示文摘 | RIVETT M O ELLIS P A MACKAY R | 2011 | Journal of Hydrology2011，400，12： | 1 |
| 10 | Modeling tetracycline antibiotic sorption to clays 显示文摘 | Figueroa R A Leonard A MacKay A A | 2004 | Environmental Science & Technology2004，38，2： | 1 |
| 11 | Differentiating infection from vaccination in foot-and-mouth disease using a panel of recombinant non-structural proteins in ELISA显示文摘 | Mackay D K J Forsyth M A Davies P R | 1997 | Vaccine1997，16，5： | 1 |
| 12 | Acute COPD exacerba tions显示文摘 | Wedzicha J A Singh R Mackay A J | 2014 | Clin Chest Med2014，35，1： | 1 |
| 13 | Stability of discrete breathers显示文摘 | MACKAY R S SEPULCHRE J A | 1998 | Phys D1998，119，： | 1 |
| 14 | Development of high-manganese steels for heavy duty cast-to-shape applications显示文摘 | SMITH R W DEMONTE A MACKAY W B F | 2004 | J Mater Process Technol2004，153，： | 1 |
| 15 | Modeling tetracycline antibiotic sorption to clays 显示文摘 | Figueroa R A Leonard A MacKay A A | 2004 | Environ Sci Technol2004，38，2： | 1 |
| 16 | Modeling tetracycline antibiotic sorption to clays显示文摘 | FIGUEROA R A LEONARD A MACKAY A A | 2004 | Environmental Science & Technology2004，38，2： | 1 |
| 17 | Differentiating infection from vaccination in foot-and-mouth disease using a panel of recombinant,non-structural proteins in ELISA显示文摘 | Mackay D K Forsyth M A Davies P R | 1998 | Vaccine1998，16，5： | 1 |
| 18 | Sorption of oxytetracycline to iron oxides and iron oxide-rich soils 显示文摘 | Figueroa R A MacKay A A | 2005 | Environ Sci Technol2005，39，17： | 1 |
| 19 | Modeling tetracycline antibiotic sorption to clays 显示文摘 | Figueroa R A Leonard A MacKay A A | 2004 | Environ Sci Technol2004，38，2： | 1 |
| 20 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
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