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| 1 | Characterization of six tumorsuppressor genes and microsatellite instability in hepatocellular carcinomain southern African blacks显示文摘AIM To analyse cumulative loss of heterozygosity (LOH) of chromosomal regions and tumor suppressor genes in hepatocellular carcinomas (HCCs) from 20 southern African blacks. METHODS p53, RB1, BRCA1, BRCA2, WT1 and E cadherin genes were analysed for LOH, and p53 gene was also analysed for the codon 249 mutation, in tumor and adjacent non tumorous liver tissues using molecular techniques and 10 polymorphic microsatellite markers. RESULTS p53 codon 249 mutation was found in 25% of the subjects, as was expected, because many patients were from Mozambique, a country with high aflatoxin B 1 exposure. LOH was found at the RB1, BRCA2 and WT1 loci in 20%(4/*!20) of the HCCs, supporting a possible role of these genes in HCC. No LOH was evident in any of the remaining genes. Reports of mutations of p53 and RB1 genes in combination, described in other populations, were not confirmed in this study. Change in microsatellite repeat number was noted at 9/*!10 microsatellite loci in different HCCs, and changes at two or more loci were detected in 15%(3/*!20) of subjects. CONCLUSION We propose that microsatellite/genomic instability may play a role in the pathogenesis of a subset of HCCs in black Africans. | Martins C Kedda MA Kew MC | 1999 | World Journal of Gastroenterology1999，5，6： | 21 |
| 2 | 冠状动脉钙化用于指导个性化阿司匹林治疗以预防心血管病:基于多民族动脉粥样硬化研究显示文摘最近美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)的一级预防指南建议,低剂量阿司匹林治疗仅适用于年龄40~70岁、患动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)风险较高,但出血风险不高的成年人。然而,尚不清楚如何更准确地识别出这些患者。根据2019年降低心血管病相对危险度和出血风险的阿司匹林荟萃分析研究数据,本研究旨在评估冠状动脉钙化(coronary artery calcium,CAC)在指导阿司匹林在一级预防中如何使用的价值。 | 周卫(译) 叶鹏(摘/审校) Achirica MC Miedema MD McEvoy JW Rifai MA Greenland P Dardari Z Budoff M Blumenthal RS Yeboah J Duprez DA Mortensen MB Dzaye O Hong J Nasir K Blaha MJ | 2020 | 中华高血压杂志2020，28，4： | 2 |
| 3 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 4 | Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC显示文摘 | Bayeux MC Fernandes AT Foglio MA | 2002 | Braz J Med Biol Res2002，35，10： | 1 |
| 5 | Insights on human evolution : an analysis of Alu insertion polymorphisms显示文摘 | Terreros MC Alfonso-Sanchez MA Novick GE | 2009 | J Hum Genet2009，54，10： | 1 |
| 6 | Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients 显示文摘 | Weijmer MC van den Dorpel MA Van de Ven PJ | 2005 | J Am Soc Nephrol2005，16，9： | 1 |
| 7 | Food poisoning and Staphylococcus aureus enterotoxins 显示文摘 | Argudin MA Mendoza MC Rodicio MR | 2010 | Toxins2010，2，7： | 1 |
| 8 | Modeling of enzymatic protein hydrolysis显示文摘 | Márquez MC Vázquez MA | 1999 | Process Biochemistry1999，35，： | 1 |
| 9 | Atrial fibrillation begets atrial fibrillation:a study in awake chronically instrumented goats显示文摘 | Wijffels MC Kirchhof CJ Dorland R Allessie MA | 1995 | Circulation1995，92，： | 1 |
| 10 | Assessment of outcome in ankylosing spondylitis: an extended radiographic scoring system显示文摘 | Creemers MC Franssen MJ van't Hof MA | 2005 | Ann Rheum Dis2005，64，1： | 1 |
| 11 | A simple description of age-related changes in crystalline lens thickness显示文摘 | Garcia-Domene MC Díez-Ajenjo MA Gracin V Felipe A Artigas JM | | 0，，05： | 1 |
| 12 | Functional outcomes of in tramuscular botu linum toxin type A in the upper limbs of children with cerebral palsy:a phase Ⅱ tria显示文摘 | Ma WA O'flaherty SJ Waugh MC | | 0，，02： | 1 |
| 13 | Migraine is associated with an increased Risk of deep white matter lesions,subclinical posterior circulation infarcts and brain iron accumulation:the population-based显示文摘 | Krinit MC van Bnchem MA launer LJ | 2010 | MRI CAMERA Cephalalgia2010，30，： | 1 |
| 14 | Menopause,estrogens and endothelial dysfunction:current concepts显示文摘 | Irigoyen MC Spritzer PM | 2007 | Clinics2007，62，1： | 1 |
| 15 | Are intrauterine growth restriction and preterm birth associated with dental caries 显示文摘 | Saraiva MC Bettiol H Barbieri MA | 2007 | Community Dent Oral Epidemiol2007，35，2： | 1 |
| 16 | Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex 显示文摘 | Schumacher MA Crum M Miller MC | 2004 | Structure ( Camb)2004，12，5： | 1 |
| 17 | Estimation of intra- abdominal pressure by bladder pressure measurement: validity and methodology显示文摘 | Fusco MA Martins RS Chang MC | 2001 | J Trauma2001，50，： | 1 |
| 18 | Uncomplicated general anesthesia in the elderly results in cognitive decline:does cognitive decline predict morbidity and mortality显示文摘 | Lewis MC Nevo I Paniagua MA | | 0，，03： | 1 |
| 19 | Migraine as a risk factor for subclinical brain lesions显示文摘 | Kruit MC van Buchem MA Hofman PAM | | 0，，： | 1 |
| 20 | Iron- fortified rice is as efficacious as supplemental iron drops in infants and young children 显示文摘 | Beinner MA Velasquez-Melndez G Pessoa MC | 2010 | J Nutr2010，140，1： | 1 |
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