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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | A Negative Feedback Control of Transforming Growth Factor-Signaling by Glycogen Synthase Kinase 3 - mediated Smad3 Linker Phosphorylation at Ser-204显示文摘 | Millet C Yamashita M Heller M | 2009 | 1 BioI Chem2009，284，19： | 1 |
| 3 | Endocrine responses to 7 days of head-down bed rest and orthostatic tests in men and women显示文摘 | Millet C Custaud MA Maillet A | 2001 | Clinical Physiology2001，21，2： | 1 |
| 4 | Formation and Behaviour Study of an Environment-friendly Corrosion Inhibitor by Electrochemical Methods 显示文摘 | BOMMERSBACH P ALEMANY-DUMONT C MILLET J P | 2005 | Electrochimica Acta2005，51，6： | 1 |
| 5 | Hypothermia as an indicator of the acute effects of lipopolysaccharides:comparison with serum levels of IL1beta,IL6and TNF alpha显示文摘 | BlanquéR Meakin C Millet S | 1996 | Gen Pharmacol1996，27，6： | 1 |
| 6 | Multi-class pesticide analysis in human hair by gas chromatography tandem (triple quadrupole) mass spectrometry with solid phase microextraction and liquid injection显示文摘 | SALQUEBRE G SCHUMMER C MILLET M | 2012 | Analytica Chimica Acta2012，710，： | 1 |
| 7 | An analytical method coupling accelerated solvent extraction and HPLC-fluorescence for the quantification of particle-bound PAHs in indoor air sampled with a 3-stages cascade impactor 显示文摘 | Liaud C Millet M Calve S L | 2015 | Tatanta2015，131，1： | 1 |
| 8 | Level ground and uphill cycling efficiency in seated and standing positions显示文摘 | Millet GP Tronche C Fuster N | 2002 | Med Sci Sports Exerc2002，34，10： | 1 |
| 9 | Cereal supplementation modified the fibrolytic activity but not the structure of fibrolytic activities and cellulolytic bacterial community structure in the solid and liquid phases of rumen contents显示文摘 | Martin C Millet L Fonty G | 2001 | Reproduction Nutrition Development2001，41，： | 1 |
| 10 | Renal effects of ibuprofen for the treatment of patient ductus arteriosus in premature infants 显示文摘 | Giniger RP Buffet C Millet V | 2007 | Journal of Maternal - Fetal and Neonatal Medicine2007，20，4： | 1 |
| 11 | Application of single strand conformation polymorphism-PCR method for distinguishing cheese bacterial communities that inhibit Listeria monocytogenes显示文摘 | SAUBUSSE M MILLET L DELBES C | 2007 | Int J Food Microbiol2007，116，： | 1 |
| 12 | Vertical dimension in the treat-ment of the edentulous patient显示文摘 | Millet C Leterme A Jeannin C | 2010 | Rev Stomatol Chir Maxillofac2010，111，56： | 1 |
| 13 | Radiation-induced upregulation of telomerase activity escapes P13-kinase inhibition in two malignant glioma cell lines 显示文摘 | Millet P Granotier C Etienne O et ol | 2013 | Int J Oncol2013，43，2： | 1 |
| 14 | Thermogravimetric Analysis of Vanadium Phosphorus Oxide Catalysts Doped with Cobalt and Iron 显示文摘 | Martin V Millet J M M Volta J C | 1998 | J Therm Anal Calorim1998，53，1： | 1 |
| 15 | Renal effects of ibuprofen for the treatment of patient ductus arteriosus in premature infants显示文摘 | Giniger RP Buffet C Millet V | 2007 | J Matern Fetal Neonatal Med2007，20，4： | 1 |
| 16 | BTA stat and BTA TRAK: Acomparative evaluation of urine testing for the diagnosis of transitional cell carcinoma of the bladder显示文摘 | Irani J Desgrandchamps F Millet C | 1999 | Eur Urol1999，35，2： | 1 |
| 17 | Removal of heavy organics by supercritical CO2 显示文摘 | Sehgal A Yalamanchili M R Millet C | 2003 | Solid State Phenomena2003，92，： | 1 |
| 18 | Adenovirus-mediated gene transferofurokinase plasm inhibitor imhibits angiogenesis in experimental arthrltis显示文摘 | APPAMILLY F BOUQUET C MILLET V | 2002 | Gene Ther2002，9，3： | 1 |
| 19 | Comparison betweenlaser speckle contrast imaging and laser Doppler imagingto assess skin blood flow in humans显示文摘 | Millet C Roustit M Blaise S | 2011 | Microvasc Res2011，82，2： | 1 |
| 20 | Symbiont diversity in Reticulitermes santonensis ( Isoptera: Rhinotermitidae ): investigation strategy through proteomics 显示文摘 | Bauweus J Millet C Tarayre C | 2013 | Environmental Entomology2013，42，5： | 1 |
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