|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Direct analysis of the mushroom poisons α-and β-amanitin in human urine using a novel on-line turbulent flow chromatography mode coupled to liquid chromatography-high resolution-mass spectrometry/mass spectrometry显示文摘 | HELFERA G MEYER M R MICHELY J A | 2014 | Journal of Chromatography A2014，1325，： | 1 |
| 3 | An electrochemical immunosensor for aflatoxin M1 determination in milk using screenprinted electrodes显示文摘 | MICHELI L GRECCO R BADEA R | 2005 | Biosensors and Bioelectronics2005，21，4： | 1 |
| 4 | An electrochemical immunosensor for aflatoxin M1 determination in milk using screen-printed electrodes 显示文摘 | Micheli L Grecco R Badea M | 2005 | Biosens Bioelectron2005，21，4： | 1 |
| 5 | STM investigation of single layer graphite structures produced on Pt(lll) byhydrocarbon decomposition显示文摘 | Land T A Michely T Behm R J | 1992 | Surface Science1992，264，3： | 1 |
| 6 | Histograms analysis for image retrieval显示文摘 | R Brunelli O Mich | 2001 | Pattern Recogn2001，34，8： | 1 |
| 7 | Le Pouvoir reflechissant des ouvrages maritimes exposes a I' action de la houle显示文摘 | Miche R | 1951 | Ann be Ponts et Chaussees1951，1951，： | 1 |
| 8 | Histograms Analysis for Image Retrieval显示文摘 | Brunelli R Mich O | 2001 | Pattern Recognition2001，34，8： | 1 |
| 9 | Carcinogenic and endocrine disrupting effects of cigarette smoke and risk of breast cancer显示文摘 | Pierre R Band Nhu D Le Raymond Fang Michèle Deschamps | 2002 | The Lancet2002，，9339： | 1 |
| 10 | Kinetics of colour change of raspberry, sweet (Prunus avium) and sour (Prunus cerasus) cherries preserves packed in glass containers: light androom temperature effects显示文摘 | Ochoa M R Kesseler A G Michelis A D | 2001 | Journal ofFood Engineering2001，49，1： | 1 |
| 11 | Leucine supplementation im- proves muscle protein synthesis in elderly men independently of hy- peraminoacidaemia显示文摘 | Isabelle R Mich~le B Claire S | 2006 | The Journal of Physilolgy2006，575，： | 1 |
| 12 | Disposable immunosensor for the determination of domoic acid in shellfish 显示文摘 | MICHELI L RADOI A GUARINA R | 2004 | Biosens Bioelectron2004，20，： | 1 |
| 13 | An Electrochemical Immunosensor for Aflatoxin M1 Determinantion in Milk Using Screen-Printed Electrodes显示文摘 | Micheli L Grecco R Badea M | 2005 | Biosensors and Bioelectronics2005，21，4： | 1 |
| 14 | Histograms analysis for image retrieval 显示文摘 | BRUNELLI R MICH O | 2001 | Pattern Recognition2001，，8： | 1 |
| 15 | An electrochemical immunosensor for aflatoxin M1 determination in milk using screen-printed electrodes 显示文摘 | Micheli L Grecco R Badea M | 2005 | Palleschi G Biosens Bioelec- tron2005，21，4： | 1 |
| 16 | Relationship between vitellogenin and vitellin in a marine shrimp( Penaeus Semisulcatus) and molecular characterization of vitellogenin complementary DNAs显示文摘 | AVARRE JC ' MICHELIS R TIE-TZ A | 2003 | Biology of Reproduction2003，69，1： | 1 |
| 17 | Hardwaro-software cosynthesis for digital systems显示文摘 | Gupts R Micheli G D | 1993 | IEEE Design & Test of computers1993，26，4： | 1 |
| 18 | Radial distribution pattern of pectin methylesterases across the cambial region of hybrid aspen at activity and dormancy显示文摘 | Micheli F Sundberg B Goldberg R | 2000 | Plant Physiology2000，124，1： | 1 |
| 19 | Mulfirate self tuning predictive control with application to a binary distillation column 显示文摘 | Carini P Micheli P Scattolini R | 1990 | International Journal of System Science1990，21，： | 1 |
| 20 | X-Band micro-wave characterization of carbon-based nanocomposite material,absorption capability comparison and RAS design simulation显示文摘 | MICHELI D APOLLO C PASTORE R | 2010 | Composites Science and Technology2010，70，40： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员