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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma显示文摘瞄准:与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法:骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80, CD83, CD86 和 HLA 医生表示被分析。骨髓的的树枝状的房间从外部血被孤立,他们的功能被测试。吞噬作用用 FITC 葡聚糖祷告被分析,肽特殊刺激,在多形核白细胞 dI:dC 之上刺激 allogeneic T 房间和 cytokines 的分泌物的能力被测试。结果:骨髓的的树枝状的房间与 HCC 在病人被减少。在 CD80, CD83, CD86 和 HLA 医生表示的差别都没从 HCC 病人和健康控制在天真、刺激的骨髓的的树枝状的房间上被发现。肽 specific T 房间的正常吞噬作用或刺激与一个损害 allo-stimulatory 能力和减少的 IL-12 分泌物相对照被观察。结论:在病人的 mDCs 的损害 IL-12 生产能导致建议指导治疗可以提高的那 IL-12 的天真的 T 房间的一个损害 stimulatory 能力在 HCC 病人的肿瘤 specific 免疫者回答。 | Lars A Ormandy Anatol Frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F Greten | 2006 | World Journal of Gastroenterology2006，12，20： | 12 |
| 3 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 4 | Perils of Rib Fractures显示文摘 | Sharma Om P Oswanski Michael F Jolly Shashank Lauer Sherry K Dressel Rhonda Stombaugh Heather A | 2008 | The American Surgeon2008，，4： | 2 |
| 5 | 1,3-diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2显示文摘 | Sui Z Guan J Michael P F | 2000 | Bioorg Med Chem Lett2000，10，6： | 1 |
| 6 | A Daytime Complement to the Reverse Absorption Technique for Improved Automated Detection of Volcanic Ash显示文摘 | Michael J P Wayne F F Andrew K H | 2006 | Journal of Atmospheric and Ocean Technology2006，23，11： | 1 |
| 7 | HIPI and HIPlr stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains显示文摘 | Hyun T S Rao D S Saint-Dic D Michael L E Kumar P D Bradley S V Mizukami I F | | 0，，14： | 1 |
| 8 | Remote sensing and geomorphometry for studying relief production in high mountains显示文摘 | Michael P Bishop John F Shroder Jr Jeffrey D Colby | 2003 | Geomorphology2003，55，： | 1 |
| 9 | Increase glutathione hiosynthesis plays a role in nickel tolerance in thlaspi nickel hyperaecumulas显示文摘 | John L F Michael W P Ken N | 2004 | The Plant Cell2004，16，： | 1 |
| 10 | Headway on urban streets: observational data and an intervention to decrease tailgating显示文摘 | MICHAEL P G LEEMING F C DWYER W O | 2000 | Transporta- tion Research Part F2000，3，2： | 1 |
| 11 | Guidelines for the implementation of the CWELD and ACM2 spot weld models in structural dynamics 显示文摘 | Matteo P Michael I F John E M | 2004 | Finite Ele ments in Analysis and Design2004，41，2： | 1 |
| 12 | Target costing operationalization during product development:Model and application显示文摘 | Tiago P F Francisco J K N Michael R D | 2009 | Int J Production Economics2009，，118： | 1 |
| 13 | Fibmlamellar hepatocel- lular carcinoma: Imaging and pathologic findings in 31 recent cases 显示文摘 | Tomoaki I Michael P F Luigi G | 1999 | Radiology1999，213，2： | 1 |
| 14 | Geomorphology and the World Wide Web显示文摘 | John F Shroder J Michael P | 2002 | Geomorphology2002，47，： | 1 |
| 15 | Contact pressure evolution and its relation to wear in sheet metal forming 显示文摘 | Pereira Michael P Yan Wenyi Rolfe Bernard F | 2008 | Wear2008，265，： | 1 |
| 16 | Forum series : Research strategies for safety evaluation of nanomaterials, Part II: Toxicological and safety evaluation of nanomaterials, current challenges and data needs 显示文摘 | MICHAEL P H WILLIAM H F TIMOTHY D L | 2005 | Toxicol Sci2005，88，1： | 1 |
| 17 | Wear at the die radius in sheet metal stamping 显示文摘 | Pereira Michael P Yan Wenyi Rolfe Bernard F | 2012 | Wear2012，，274275： | 1 |
| 18 | The role of elevation and soil chemistry in the distribution and ion accumulation of floral morphs of Streptanthus polygaloides Gray (Brassicaceae), a Californian nickel?hyperaccumulator 显示文摘 | Nathaniel P Michael F Robert S B | 2014 | Plant ecology & diversity2014，7，42： | 1 |
| 19 | Probabilistic analysis of resistance degradation of reinforced concrete bridge beams under corrosion显示文摘 | MICHAEL P E DAN M F | 1998 | Engineering Structures1998，，20： | 1 |
| 20 | Increased glutathione biosynthesis plays a role in nickel tolerance in thlaspi nickel hyperaccumulators显示文摘 | John L F Michael W P Ken N | 2004 | The Plant Cell2004，16，： | 1 |
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