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| 1 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 2 | Isolation and proteomic analysis of the SYP61 compartment reveal its role in exocytic trafficking in Arabidopsis显示文摘endomembrane 系统是建筑群和动态细胞内部的 trafficking 网络。它很正在质问在实时追踪单个泡和他们的货物;然而,亲密关系纯化允许泡处于他们的自然状态被孤立以便他们的成分蛋白质能被识别。在植物开创这条途径,我们孤立 SYP61 trans-Golgi 网络分隔空间并且与从另外的细胞器的仅仅最小的干扰执行了它的内容的全面 proteomic 分析。SYP61 的 proteome 揭示了以前没被归功于到这分隔空间的未知功能的蛋白质的协会。我们识别了完全的 SYP61 圈套建筑群,包括规章的蛋白质并且由显示出在 planta 与 SYP61 联系的几这些蛋白质验证了 proteome 数据。我们进一步识别了 SYP121 复杂并且纤维素 synthases,建议那 SYP61 在 exocytic trafficking 和房间墙部件的运输起一个作用到血浆膜。在包括针鼹鼠的 SYP61 proteome 的未知功能的蛋白质的存在提供机会识别新奇 trafficking 部件和货物。处于他们的自然状态的植物泡的亲密关系纯化为复杂 endomembrane 网络的进一步的分析和解剖提供一个基础。途径是广泛地适用的并且能在植物负担得起几张泡人口的学习,它能与 SYP61 泡 proteome 相比。 | Georgia Drakakaki Wilhelmina van de Ven Songqin Pan Yansong Miao Junqi Wang Nana F Keinath Brent Weatherly Liwen Jiang Karin Schumacher Glenn Hicks Natasha Raikhel | 2012 | Cell Research2012，22，2： | 4 |
| 3 | Effects of Cu content and preaging on precipitation characteristics in aluminum alloy 6022 显示文摘 | MIAO W F LAUGHLIN D E | 2000 | Metallurgical and Materials Transactions A2000，31，2： | 1 |
| 4 | A novel synthesis and characterization of LiFePO4 of LiFePOJC as a cathode mate- rial for lithium-ion battery 显示文摘 | Miao C Bai P F Jiang Q Q | 2014 | Journal of Power Sources2014，245，： | 1 |
| 5 | How do alumni faculty behave in research collaboration? an analysis of Chang Jiang Scholars in China显示文摘 | LI F MIAO Y YANG C | 2015 | Research Policy2015，44，2： | 1 |
| 6 | Application of improved sparse A* algorithm in UAV path planning显示文摘 | Miao Y F Zhong L X Luo S | 2013 | Information Technology Journal2013，12，17： | 1 |
| 7 | Three-dimensional finite element analyses of passive pile behaviour显示文摘 | Miao L F Goh A T C Wong K S | 2006 | International Journal for Numerical and Analytical Methods in Geomechanics2006，，30： | 1 |
| 8 | Evidence relationship matrix and its application to D-S evidence theory for information fusion显示文摘 | Fan X F Huang H Z Miao Q | 2006 | LNCS IDEAL2006，4224，： | 1 |
| 9 | Cloning and expression of manganese superoxide dismutase of the silkworm,Bombyx mori by Bac-to-Bac/BmNPV Baculovirus expression system显示文摘 | Yue W F Miao Y G Nakagaki M | 2006 | Appl Microbiol Biotechnol2006，73，1： | 1 |
| 10 | An Observational and Modeling Study of Characteristics of Urban Heat Island and Boundary Layer Structures in Beijing 显示文摘 | Miao S G Chen F Lemone M A | 2009 | Journal of Applied Meteorology and Climatology2009，48，3： | 1 |
| 11 | Treatment of symptom- atie middle cerebral artery stenosis with balloon- mounted stents: long-term follow-up at a single center 显示文摘 | Miao ZR Feng L Zhu F | 2009 | Neurosurgery2009，64，1： | 1 |
| 12 | Localization of a new gene for bitterness in cucumber显示文摘 | Zhang S P Miao H Sun R F | 2013 | Journal of Heredity2013，104，1： | 1 |
| 13 | Risk prediction of one- year mortality in patients with cardiac arrhythmias using random survival forest显示文摘 | Miao F Cai YP Zhang YX | 2015 | Comput Math Methods Med2015，2015，30： | 1 |
| 14 | Screening genetically modified organisms using multiplex - PCR coupled with oligonucleotide microbar-ray显示文摘 | Xu J Miao H Z Wu H F | 2006 | Biosensors and Bioelectronics2006，22，1： | 1 |
| 15 | Fluorinated hyperbranched polyester acrylate used as an additive for UV curing coatings显示文摘 | Miao H Cheng L L Shi W F | 2009 | Prog Org Coat2009，65，1： | 1 |
| 16 | Structure and magnetic properties of mechanically milled Nd2xFe100-3xBx(x-2-6) 显示文摘 | Miao W F Ding J and Mccormick P G | 1996 | J Alloy Comp1996，240，： | 1 |
| 17 | In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions显示文摘 | Miao F Gonzalo IG Lanting L | 2004 | J Biol Chem2004，279，18： | 1 |
| 18 | In vitro antifungal activity of sanguinarine and chelerytbrine derivatives against phytopatho- genic fungi 显示文摘 | Yang X J Miao F Yao Y | 2012 | Molecules2012，17，13： | 1 |
| 19 | Risk factors for dementia with type 2 diabetes mellitus among elderly people in China 显示文摘 | Ma F Zhang YP Miao R J | 2013 | Age Ageing2013，42，3： | 1 |
| 20 | Mutations in the N-terminal coding region of the harpin protein hpal from Xan- :homonas oryzae cause loss of hypersensitive reaction induction in tobacco 显示文摘 | WANG X Y SONG C F MIAO W G | 2008 | Appl Microbiol Biotechnol2008，81，： | 1 |
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