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| 1 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 2 | Diagnostic neuroradiology:Ready for the neurointerventional age?显示文摘Acute cerebral ischemia or stroke is currently considered an emergency for which therapeutic options are available if the therapeutic window of 4.5 h is respected.Imaging modalities have progressed greatly over the last few decades,rendering ischemia detectable in the first hours after the event.However,in order for treatment to be efficacious it is necessary to speed up all the processes before the start of therapy.Thus,one must decrease the time to arrival at the hospital and to the radiological method that is to be employed(be it computed tomography or magnetic resonance imaging);only then will the medical or interventional techniques available fulfill their potential. | Karl-Olof Lvblad Vitor Mendes Pereira | 2012 | World Journal of Radiology2012，4，9： | 2 |
| 3 | An enzyme-linked immunosorbent assay for the detection of vesicular stomatitis virus antibodies 显示文摘 | Allende R Sepulveda L Mendes da Silva A | 1992 | Prev Vet Med1992，14，： | 1 |
| 4 | Effect of frozen storage on thechemical and physical properties of black and silver scabbard fish显示文摘 | DAIAS J NUNES M L MENDES R | 1994 | Journal of the Science of Food and Agriculture1994，66，3： | 1 |
| 5 | Effect of transglutaminaseand carrageenan on restructured fish products containing dietaryfibres 显示文摘 | Cardoso C Mendes R Nunes M L | 2007 | International Journal of Food Science and Technology2007，42，： | 1 |
| 6 | Acclima- tion of Myrtus communis to contrasting Mediterranean light environments effects on structure and chemical composition of foliage and plant water relations 显示文摘 | Mendes M M Gazarini L C Rodrigues M L | 2001 | En- vironmental and Experimental Botany2001，45，2： | 1 |
| 7 | Theinfluence of doublepulse on porosity formation in aluminum GMAW 显示文摘 | Mendes da Silva C L Scotti A | 2006 | Journal of Materials Processing Technology2006，171，： | 1 |
| 8 | Pharmacodynamic comparisons of antimicrobials against nosocomial isolates of escherichia coli,klebsiella pneumoniae,acinetobacter baumannii and pseudomonas aeruginosa from the MYSTIC surveillance program:the OPTAMA Program,South America 2002显示文摘 | KIFFER C R MENDES C KUTI J L | 2004 | Diagn Microbiol Infect Dis2004，49，2： | 1 |
| 9 | Travel and Tourism: Into a Com- plex Network显示文摘 | Migu6ns J I L Mendes J F F | 2008 | Physica A2008，387，： | 1 |
| 10 | Development of a healthylow-fat fishsausage containing dietary fibre 显示文摘 | Cardoso C Mendes R Nunes M L | 2008 | InternationalJournal of Food Science andTechnology2008，43，： | 1 |
| 11 | Load-independent parameters of diastolic and systolic function by speckle tracking and tissue doppler in hemodialysis patients 显示文摘 | Mendes L Ribeiras R Adragao T | 2008 | Rev Port Cardiol2008，27，9： | 1 |
| 12 | Obstruction of pipelines due to paraffin deposition during the flow of crude oils显示文摘 | Ribeiro F S Mendes P R S Braga S L | 1997 | International Journal of Heat Mass Transfer1997，18，1： | 1 |
| 13 | Rolling - circle amplification of Torque teno virus ( TTV ) complete genomes from human and swine sera and identification of a novel swine TTV genogroup 显示文摘 | NIEL C DINIZ - MENDES L DEVALLE S | 2005 | J Virol2005，86，： | 1 |
| 14 | Travel and tourism: into a complex network显示文摘 | Migu6ns J I L Mendes J F F | 2008 | Physica A : Statistical Mechanics and its Applications2008，387，12： | 1 |
| 15 | Prediction of success in external cephalic version under toco- lysis: still a challenge显示文摘 | VAZ DE MACEDO C CLODE N MENDES DA GRA A L | 2015 | Acta Medica Portuguesa2015，28，5： | 1 |
| 16 | 牙周炎与高血压的相关性显示文摘牙周炎是一种常见的慢性炎症性疾病,可能会对血压产生重要影响。本研究旨在探究:(1)在一项大型代表性队列中研究牙周健康与血压的相关性;(2)牙周炎在未明确诊断血压升高患者中的诊断预测价值;(3)年龄是否在牙周健康与血压的相关性中起介导作用。在纳入随机招募的参与者1057例[平均年龄(60.9±16.3)岁,57.7%为女性]中行牙周临床评估,并使用自动血压计测量单次血压。 | 袁源(摘译) 练桂丽(审校) Machado V Aguilera EM Botelho J Hussain SB Leira Y Proenca L D’Aiuto F Mendes JJ | 2020 | 中华高血压杂志2020，28，9： | 1 |
| 17 | Theinfluence of doublepulse on porosity formation in aluminum GMAW 显示文摘 | Mendes da Silva C L Scotti A | 2006 | Journal of Materials Processing Technology2006，171，： | 1 |
| 18 | Recovery of the high aggregated compounds present in the deodorizer distillate of the vegetable oils using supercritical fluids 显示文摘 | Mendes M F Pessoa F L P Coelho G V | 2005 | Journal of Supercritical Fluids2005，，34： | 1 |
| 19 | Linezolid update: stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanisms显示文摘 | Mendes R E Deshpande L M Jones R N | 2014 | Drug Resist Updat2014，，： | 1 |
| 20 | 显示文摘 | SUMNER L W MENDES P DIXON R A | 2003 | Phytochemistry2003，62，6： | 1 |
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