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| 1 | Progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of acute pancreatitis显示文摘BACKGROUND: Acute pancreatitis (AP) is a common acute abdomen with high mortality, multiple complications and complicated causes. There is no effective therapy for AP. Radix salviae miltiorrhizae (Danshen), a traditional herbal medicine, has a low price and a wide range of clinical applications. It is effective to promote blood flow, eliminate stagnancy, and relieve pain. It is also found to be effective in treating AP. We reviewed the progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of AP. DATA SOURCES: An english-language literature search was conducted using MEDLINE (1988-2005) on Radix salviae miltiorrhizae (Danshen) and acute pancreatitis. RESULTS: The mechanisms of Danshen in the treatment of AP include improvement of microcirculatory disturbances; elimination of oxygen free radicals; modulation of the metabolism of lipid inflammatory mediator; and blocking of calcium inflow and prevention of calcium overload.CONCLUSION: Danshen can effectively reduce the mortality and complications of AP. | Xi-Ping Zhang, Zhi-Jun Li and Da-Ren Liu Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, China , Zhejiang University of Traditional Chinese Medine, Hangzhou 310053, China Department of General Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 15 |
| 2 | Yin and Yang of mesenchymal stem cells and aplastic anemia显示文摘Acquired aplastic anemia(AA) is a bone marrow failure syndrome characterized by peripheral cytopenias and bone marrow hypoplasia. It is ultimately fatal without treatment, most commonly from infection or hemorrhage. Current treatments focus on suppressing immune-mediated destruction of bone marrow stem cells or replacing hematopoietic stem cells(HSCs) by transplantation. Our incomplete understanding of the pathogenesis of AA has limited development of targeted treatment options. Mesenchymal stem cells(MSCs) play a vital role in HSC proliferation; they also modulate immune responses and maintain an environment supportive of hematopoiesis. Some of the observed clinical manifestations of AA can be explained by mesenchymal dysfunction. MSC infusions have been shown to be safe and may offer new approaches for the treatment of this disorder. Indeed, infusions of MSCs may help suppress auto-reactive, T-cell mediated HSC destruction and help restore an environment that supports hematopoiesis. Small pilot studies using MSCs as monotherapy or as adjuncts to HSC transplantation have been attempted as treatments for AA. Here we review the current understanding of the pathogenesis of AA and the function of MSCs, and suggest that MSCs should be a target for further research and clinical trials in this disorder. | Larisa Broglie David Margolis Jeffrey A Medin | 2017 | World Journal of Stem Cells2017，9，12： | 3 |
| 3 | Stem cell differentiation and human liver disease显示文摘Human stem cells are scalable cell populations capable of cellular differentiation.This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells.Such an approach has the potential to improve our understanding of human biology and treating disease.In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases.In recent years,eff icient hepatic differentiation from human stem cells has been achieved by several research groups including our own.In this review we provide an overview of the f ield and discuss the future potential and limitations of stem cell technology. | Wen-Li Zhou Claire N Medine Liang Zhu David C Hay | 2012 | World Journal of Gastroenterology2012，18，17： | 3 |
| 4 | Nanocrystalline metal oxides: a new family of mesoporous inorganic materials useful for destructive adsorption of environmental toxins显示文摘 | Klabunde KJ Medine G Bedilo A | 2005 | Acs Symp Ser2005，890，： | 1 |
| 5 | Respects for Similarity显示文摘 | Medin D L Goldstone R L Gentner D | 1993 | Psychological Review1993，100，2： | 1 |
| 6 | Smoothed Particle Hydrodynamics Using Interparticle Contact Algorithm 显示文摘 | Parshikov A N Medin S A | 2002 | J Comput Phys2002，180，： | 1 |
| 7 | Cancer immunotherapy using virally tran- duced dendritic cells: Aninml studies and human clinical trails 显示文摘 | Mossoba ME Medin JA | 2006 | Expert Rev Vaccines2006，5，5： | 1 |
| 8 | Folkecology,cultural epidemiology,and the spirit of the commons:A garden experiment in the maya lowlands,19912001 1显示文摘 | Atran S Medin D Ross N | 2002 | Current Anthropology2002，43，3： | 1 |
| 9 | Improvements in SPH Method by Means of Interparticle Contact Algorithm and Analysis of Perforation Tests at Moderate Projectile Velocities 显示文摘 | Parshikov A N Medin S A Loukashenko I I | 2000 | Int J Impact Eng2000，24，： | 1 |
| 10 | Concept and concept formation 显示文摘 | Medin D L Smith E E | 1984 | Annual Review Psychology1984，35，2： | 1 |
| 11 | Categorization and reasoning among tree experts: do all roads lead to Rome显示文摘 | | 1997 | Cognitive Psychology,1997，32，： | 1 |
| 12 | Elderly persons'ex- perience and management of eating situations 6 months after stroke显示文摘 | Medin J Larson J Von Arbin M | 2010 | Disabil Rehabil2010，32，16： | 1 |
| 13 | Indirect electrosynthesis of p-methoxybenzaldehyde 显示文摘 | Kreysa G Medin H | 1986 | J Appl Electrochem1986，16，： | 1 |
| 14 | Factors Behind the Environmental Kuznets Curve显示文摘 | Bruvoll A Medin H | 2003 | Environmental and Resource Economics2003，，24： | 1 |
| 15 | Dosimetrie verification of RapidArc treatment delivery显示文摘 | Korreman S Medin J Kjaer-Kristoffersen F | | 0，，： | 1 |
| 16 | Improved Techniques to Alle- viate Sustained Casing Pressure in a Mature Gulf of Mexico Field 显示文摘 | Kevin Soter Felix Medine | 2003 | SPE 84556- MS2003，，： | 1 |
| 17 | Hepatitis C transmission in a hemodialysis unit: molecular evidence for spread of virus among patients not sharing equipment显示文摘 | Allander T Medin C Jacobson SH | 1994 | J Med Virol1994，43，4： | 1 |
| 18 | Physiological changes in pigs exposed to a blast wave from a detonating high-explosive charge 显示文摘 | Axelsson H Hjelmqvist H Medin A | 2000 | Mil Med2000，165，2： | 1 |
| 19 | Improvements in SPH method by means of interparticle contact algorithm and analysis of perforation tests at moderate projectile velocities显示文摘 | Parshikov A N Medin S A Loukashenko I I | 2000 | Int J Impact Eneng2000，24，8： | 1 |
| 20 | Physiologica chan- ges in pigs exposed to a blastwave from a detonating high - ex- plosive charge 显示文摘 | Axelsson H H ielmqvist H Medin A | 2000 | Mil M ed2000，165，2： | 1 |
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