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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Season of the year influences infection rates following total hip arthroplasty显示文摘AIM To research the influence of season of the year on periprosthetic joint infections.METHODS We conducted a retrospective review of the entire Medicare files from 2005 to 2014. Seasons were classified as spring, summer, fall or winter. Regional variations were accounted for by dividing patients into four geographic regions as per the United States Census Bureau(Northeast, Midwest, West and South). Acute postoperative infection and deep periprosthetic infections within 90 d after surgery were tracked. RESULTS In all regions, winter had the highest incidence of periprosthetic infections(mean 0.98%, SD 0.1%) and was significantly higher than other seasons in the Midwest, South and West(P < 0.05 for all) but not the Northeast(P = 0.358). Acute postoperative infection rates were more frequent in the summer and were significantly affected by season of the year in the West.CONCLUSION Season of the year is a risk factor for periprosthetic joint infection following total hip arthroplasty(THA). Understanding the influence of season on outcomes following THA is essential when risk-stratifying patients to optimize outcomes and reduce episode of care costs. | Samuel Rosas Alvin C Ong Leonard T Buller Karim G Sabeh Tsun yee Law Martin W Roche Victor H Hernandez | 2017 | World Journal of Orthopedics2017，8，12： | 4 |
| 3 | A new Early Cretaceous dinosaur track assemblage and the first definite non-avian theropod swim trackway from China显示文摘The trackway of a swimming theropod (ichnogenus Characichnos) is reported from the Lower Cretaceous Feitianshan Formation of Sichuan, China. These swim tracks help confirm that non-avian theropods were capable of forging moderately deep bodies of water. The trackway occurs on the same surface as a typical walking trackway of a sauropod (ichnogenus Brontopodus). Both occurrences are the first reported from the Cretaceous of Sichuan, and the swim tracks are the first well-preserved example of a Characichnos trackway from China. Additionally, a theropod walking trackway and several ornithopod walking trackways (similar to the ichnogenus Caririchnium) occur in the same horizon. The ornithopod trackways show a parallel orientation, suggesting gregarious behavior of the trackmakers, which may have been iguanodontiforms and/or hadrosauriforms. The co-occurrence of theropod swim tracks and theropod walking tracks suggests a fluctuation of water depth within a distinct time span. | XING LiDa LOCKLEY Martin G ZHANG JianPing MILNER Andrew R C KLEIN Hendrik LI DaQing PERSONS IV W Scott EBI JieFang | 2013 | Chinese Science Bulletin2013，58，19： | 3 |
| 4 | Efficacy and safety of d, 1-sotalol in patients with ventricular tachycardia and in survivors of cardiac arrest显示文摘 | Haverkamp W Martines RA Hief C et ai | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 5 | An experimental study of the collapse of fluid columns on a rigid horizontal plane显示文摘 | Martin J C Moyce W J | 1952 | Philosophical Transactions of the Royal Society of London:Series A1952，244，882： | 1 |
| 6 | Invasion and Intracellular sur- vival of Burkholderia cepacia显示文摘 | Martin D W Mohr C D | 2000 | Infection and Immu- nity2000，68，1： | 1 |
| 7 | Aerial application methods for increasing spray deposition on wheat heads 显示文摘 | Fritz B K Hoffmann W C Martin D E | 2007 | Applied Engineering in Agriculture2007，23，6： | 1 |
| 8 | Particulate air pollution and daily mortality on Utah's wasatch front 显示文摘 | Arden P C Randy W H Martin G V | 1999 | Environmental Health Perspectives1999，107，7： | 1 |
| 9 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 10 | WACS--wide-area stability and voltage control system: R g~ D and online demonstration 显示文摘 | TAYLOR C W ERICKSON D C MARTIN K E | 2005 | Proceedings of the IEEE2005，93，5： | 1 |
| 11 | Mammalian caspases: structure, activation, substrates, and functions during apoptosis显示文摘 | EARNSHAW W C MARTINS L M KAUFMANN S H | 1999 | Annu Rev Biochem1999，68，： | 1 |
| 12 | Sequencing of cDNA clones from the genetic map of tomato(lycopersicon esculentum) 显示文摘 | Martin W G Rosemarie C Ulrich H | 1998 | Genome Research1998，8，8： | 1 |
| 13 | Environmental applications of semiconductor photocatalysis显示文摘 | HOFFMANN M R MARTIN S T WONGYONG C BAHNEMANN D W | 1995 | Chem Rev1995，95，： | 1 |
| 14 | Meniscal tears: pathologic correlation with MR imaging 显示文摘 | Stoller D W Martin C Crues J V 3rd | 1987 | Radiology1987，163，3： | 1 |
| 15 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 16 | Effect of arbuscular mycorrhizal(AM) fungal communities on growth of 'Volkamer' lemon in continually moist or periodically dry soil显示文摘 | FIDELIBUS M W MARTIN C A WRIGHT G C | 2000 | Scientia Horticulturae2000，84，1： | 1 |
| 17 | Foliar trichomes, boundary layers, and gas exchange in 12 species of epiphytic Tillandsia显示文摘 | BENZ B W MARTIN C E | 2006 | Journal of Plant Physiology2006，163，： | 1 |
| 18 | The composition of octopus renal fluid I Inorganic constitution显示文摘 | Emmanuel C F Martin A W | 1956 | Z vergl Physiol1956，39，： | 1 |
| 19 | Selective process for efficient isolation of soil Bacillus spp显示文摘 | Travers R S Martin P A W Reichelderfer C F | | 0，，06： | 1 |
| 20 | Crassulacean acid metabolism, CO2-recycling, and tissue desiccation in the Mexican epiphytc Tillandsia schiedeana Steud显示文摘 | MARTIN C WILLIAM W A | 1987 | Photosynthesis Research1987，11，： | 1 |
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