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| 1 | Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial显示文摘 | Martijn HGM van der Pas Eva Haglind Miguel A Cuesta Alois Fürst Antonio M Lacy Wim CJ Hop Hendrik Jaap Bonjer | 2013 | Lancet Oncology2013，，： | 17 |
| 2 | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation显示文摘BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis.In a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic control.AIM To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with Aramchol.METHODS Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 h.Subsequently,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled glucose.For the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 wk.Liver metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related metabolites.RESULTS Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes.This translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA cycle.Finally,liver metabolomic analysis showed that glucose homeostasis was improved by Aramchol in 0.1MCD fed mice in a dose-dependent manner,showing normalization of glucose,G6P,F6P,UDP-glucose,and Rbl5P/Xyl5P.CONCLUSION Aramchol exerts its effect on glucose and lipid metabolism in NASH through activation of AMPK and inhibition of mTORC1,which in turn activate FAβ-oxidation and oxidative phosphorylation. | David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 4 | Synthesis of protective Mo-Si-B coatings in molten salts and their oxidation behavior in an air-water mixture 显示文摘 | Sergey A Kuznetsov Evgeny V Rebov Martijn J M M | 2006 | Surface and Coatings Technology2006，201，34： | 1 |
| 5 | Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial显示文摘 | Martijn HGM van der Pas Eva Haglind Miguel A Cuesta Alois Fürst Antonio M Lacy Wim CJ Hop Hendrik Jaap Bonjer | 2013 | Lancet Oncology2013，，： | 1 |
| 6 | Multiple-ramp column-parallel ADC architec- tures for CMOS image sensors显示文摘 | Martijn F Snoeij Albert J P Theuwissen Kofi A A Makinwa | 2007 | IEEE Journal Of Solid-State Circuits2007，42，12： | 1 |
| 7 | Word sense disambiguation in the biomedical domain:an overview显示文摘 | Martijn J Jan A Barend M | 2005 | Journal of Computational Biology2005，12，5： | 1 |
| 8 | High-Intensity Pulse Progation in uniform Gratings and Grating Superstructures 显示文摘 | de Sterke C Martijn Eggleton Benjamin J Krug Peter A | 1997 | Journal of Lightwave Technology1997，15，8： | 1 |
| 9 | Synthesis of Protective Mo-Si-B Coatings in Molten Salts and Theiroxidation Behavior in an Air-Water Mixture显示文摘 | Rebrov Evgeny V Mies Martijn J M | 2006 | Surface & Coatings Technology2006，201，： | 1 |
| 10 | Induction of programmed cell death in lily by the fungal pathogen Botry- tis elliptica 显示文摘 | Peter Van Baarlen Martijn Staats Vankan J A L | 2004 | Molecular Plant Pathology2004，5，6： | 1 |
| 11 | Performance of subcutaneously implanted glucose sensor:a review显示文摘 | Jansen J A Alexander Kros | 1998 | Journal of Investigative Surgery1998，11，： | 1 |
| 12 | Centralnervous tissue damage after hypoxia and reperfusion inconjunction with cardiac arrest and cardiopulmonaryresuscitation : mechanisms of action and possibilities formitigation显示文摘 | Wiklund L Martijn C Miclescu A | 2012 | Int Rev Neurobiol2012，102，： | 1 |
| 13 | Theoretical, numerical, and experimental analysis of optical fiber tapering显示文摘 | Xue Shicheng Martijn A van Eijkelenborg GeoffW Barton | 2007 | Journal of Lightwave Technology2007，25，5： | 1 |
| 14 | Supramolecular copolyesters with tunable properties显示文摘 | D J M van Beek Martijn A J Gillissen Bart A C van As | 2007 | Macromolecules2007，40，17： | 1 |
| 15 | Influence of prenatal organohalogen levels on infant male sexual development: sex hormone levels, testes volume and penile length 显示文摘 | Meijer L Martijn A Melessen J | 2012 | Hum Reprod2012，27，3： | 1 |
| 16 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 1 |
| 17 | The course of hepatitis E virus infection in pigs after contact-infection and intrave- nous inoculation显示文摘 | Martijn B Saskia A R Chantal B R | 2009 | BMC Veterinary Research2009，5，： | 1 |
| 18 | Global microRNA profiling of well-differentiated small intestinal neuroendocrine tumors显示文摘 | Li SC Essaghir A Martijn C | 2013 | Mod Pathol2013，26，5： | 1 |
| 19 | Saturated fat and heart disease 显示文摘 | Martijn B Katan Ingeborg A Brouwer Robert Clarke | 2010 | American Journal of Clinical Nutrition2010，92，2： | 1 |
| 20 | Pharmacology in the elderly and newer anaesthesia drugs显示文摘 | Martijn R Kruijt S Nicolaas A | 2011 | Best Practice & Research Clinical Anaesthesiology2011，25，3： | 1 |
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