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| 1 | Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease显示文摘BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver axis.We hypothesize that, diet could be able to modulate intestinal permeability in patients with NAFLD.AIM To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat diet.METHODS The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat diet.CONCLUSION Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. | Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio Valenza Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 2 | 神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。 | 唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A | 2018 | 神经损伤与功能重建2018，13，2： | 2 |
| 3 | Corrosion control methods in supercritical water oxidation and gasification process 显示文摘 | Marrone P A Hong G T | 2009 | The Journal of Supercritical Fluids2009，51，2： | 1 |
| 4 | Wavelet analysis of blood pressure waves in vasovagal syncope显示文摘 | Marrone A Polosa AD Scioscia G | 1999 | Physics1999，，271： | 1 |
| 5 | Immunocompromised patients with HBsAg a determinant mutants: comparison of HBsAg diagnostic assays显示文摘 | Veropalumbo E Marrone A Vallefuoco L | | 0，，： | 1 |
| 6 | A multilevel investigation of antecedents and consequences of team member boundary-spanning behavior显示文摘 | Marrone J A Tesluk P E Carson J B | 2007 | Academy of Management Journal2007，50，6： | 1 |
| 7 | A Multilevel Investigation of Antecedents and Conse- quences of Team Member Boundary-Spanning Behav- ior显示文摘 | MARRONE J A TESLUK P E CARSON J B | 2007 | Academy of Management Journal2007，50，6： | 1 |
| 8 | Clinical reactivation during lamivudine treatment correlates with mutations in the precore/ core promoter and polymerase regions of hepatitis B virus in patients with anti - hepatitis B e - positive chronic hepatitis 显示文摘 | Marrone A Zampino R Karayannis P | 2005 | Aliment Pharmacol Ther2005，22，8： | 1 |
| 9 | Pericardial fluid postmortem: Comparative study of natural and violent deaths显示文摘 | Arroyo A Valero J Marron T | 1998 | Am J Forensic Med Pathol1998，19，3： | 1 |
| 10 | Polarisation-insensitive fibre optic Michelson interferometer显示文摘 | Kersey A D Marrone M J | 1991 | Electron Lett1991，27，6： | 1 |
| 11 | Shared leadership in teams= An investigation of anteeedent conditions and per- formance显示文摘 | Carson J B Tesluk P E and Marrone J A | 2007 | Academy of Management Journal2007，50，5： | 1 |
| 12 | Impact of end-stage renal disease care in planned dialysis start and type of renal replacement therapy a Spanish multicentre experience显示文摘 | Marron B Ortiz A de Sequera P | 2006 | Nephrol Dial Transplant2006，21，2： | 1 |
| 13 | Optimization and Stabilization of Visibility in Interferometrie Fiber-Optic Sensors Using Input-Polarization Control 显示文摘 | A D Kersey M J Marrone A Dandridge | 1988 | Lightwave Technology1988，6，10： | 1 |
| 14 | Optimization and stabilization of visibility in interferometric fiber-optic sensors using input-polarization control 显示文摘 | Kersey A D Marrone M J Dandridge A | 1988 | Lightwave Technology1988，6，10： | 1 |
| 15 | Respiratory disorders during sleep in chronic obstructive pulmonary disease显示文摘 | Marrone O Salvaggio A Insalaco G | 2006 | Int J Chron Obstruct Pulmon Dis2006，1，： | 1 |
| 16 | Team boundary spanning: A multilevel review of past research and proposals for the future显示文摘 | Marrone J A | 2010 | Journal of Management2010，36，4： | 1 |
| 17 | Team boundary spanning:a multilevel review of past research and proposals for the future 显示文摘 | MARRONE J A | 2010 | Journal of manage- ment2010，36，4： | 1 |
| 18 | Simple estimation of prevalence of Hortonian flow in New York City Watershed显示文摘 | Walter M T V K Mehta A M Marrone J | 2003 | Journal of Hydrology Engineering2003，，8： | 1 |
| 19 | Identification of a mutation associated with factor XI deficiency in Holstein cattle显示文摘 | MARRON B M ROBINSONJ L GENTRY P A et a1 | 2004 | Anim Genet2004，35，6： | 1 |
| 20 | Shared leadership in teams:an investigation of antecedent conditions and performance显示文摘 | CARSON J B TESLUK P E MARRONE J A | 2007 | Academy of Management Journal2007，50，5： | 1 |
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