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| 1 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 2 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 3 | Identifying and assessing ecotourism visitor impacts at eight protected areas in Costa Rica and Belize显示文摘 | Tracy A Farrell Jeffrey L Marion | 2001 | Environment Conservation2001，28，3： | 1 |
| 4 | Real-time reverse transcription PCR analysis of expression of atrazine catabolism genes in two bacterial strains isolated from soil 显示文摘 | Marion D Guy S Fabrice M L | 2004 | Journal of Microbiological Methods2004，56，1： | 1 |
| 5 | Systematic analysis of protein subcellular localization and interaction using high-throughput tran sient transformation of Arabidopsls seedlings显示文摘 | MARION J BACH L BELLEC Y | 2008 | Plant Journal2008，56，1： | 1 |
| 6 | Treatment of traumatic brain injury with moderate hypothermia 显示文摘 | MARION D W PENROD L E KELSEY S F | 1997 | N Engl J Med1997，336，8： | 1 |
| 7 | Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence显示文摘AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data.RESULTS Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC < 2.35 × 10^(-3) mm^2/s [sensitivity = 0.85, specificity = 0.65, positive predictive value(PPV) = 0.85, negative predictive value(NPV) = 0.65] and RCE > 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high performances to detect endoscopic POR(sensitivity = 0.67, specificity = 0.93, PPV = 0.89 and NPV = 0.77).CONCLUSION Faecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD. | Pierre Baillet Guillaume Cadiot Marion Goutte Felix Goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson | 2018 | World Journal of Gastroenterology2018，24，5： | 1 |
| 8 | Comparison between oral and vaginal administration of misoprostol on uterine contractility显示文摘 | Danielsson KG Marions L Rodriguez A | 1999 | Obstet Gynecol1999，93，： | 1 |
| 9 | Ametaanalysis of the response of soil respiration,net nitrogen mineralization,and aboveground plant growth to experimental ecosystem warming显示文摘 | RUSTAD L E CAMPBELL J L MARION G M | 2001 | Oecologia2001，126，4： | 1 |
| 10 | The solubilities of carbonates and phosphates in calcareous soil suspensions显示文摘 | Marion G M and K L Babcock | 1977 | Psssa1977，41，： | 1 |
| 11 | Synthesis of azolyl carboximidamides as ligands for Zn(11)and Cu(11):application of the Zn(11)complexes as catalysts for the copolymerization of carbon dioxide and epoxides显示文摘 | Martin W Kurt W Marion L | 2006 | J Org Chem2006，71，： | 1 |
| 12 | A Meta analysis of the Response of Soil Respiration, Net Nitrogen Mineralization and Aboveground Plant Growth to Experimental Ecosystem Warming 显示文摘 | Rustad L E Campbell J L Marion G M | 2001 | Oecologia2001，126，： | 1 |
| 13 | A meta-analysis of the response of soil respiration, net nitrogen mineralization, and aboveground plant growth to experimental ecosystem warming显示文摘 | Rustad L Campbell J Marion G | 2001 | Oecologia2001，126，： | 1 |
| 14 | High occurrence of a new variant of Chlamydia trachomatis escaping diagnostic tests among STI clinic patients in Stockholm,Sweden显示文摘 | Marions L Rotzen-Ostlund M Grillner L | 2008 | Sex Transm Dis2008，35，1： | 1 |
| 15 | Comparison between oral and vaginal administration of misoprostol on uterine contractility显示文摘 | Marions L Rodriguez A | 1999 | Obstet Gonecol1999，93，： | 1 |
| 16 | A comprehensive review of opioid-in- duced hyperalgesia显示文摘 | Marion L Sanford S Hans H | 2011 | Pain Physician2011，14，2： | 1 |
| 17 | Bird assemblages as bio - indicators of water regime management and hunting disturbance in natural wet grasslands 显示文摘 | PAILLISSON J M REEBER S MARION L | 2002 | Biological Conservation2002，106，1： | 1 |
| 18 | A meta-analysis of the response of soil respiration, net nitrogen mineralization, and aboveground plant growth to experimental ecosystem wanning 显示文摘 | Rustad L E Campbell J L Marion G M | 2001 | Oecolo- gia2001，126，： | 1 |
| 19 | 显示文摘 | Esther L Marion G Marjan S | 2002 | Arterioscler Thromb Vasc Biol2002，22，： | 1 |
| 20 | A meta- analysis of the response of soil respiration, net nitro gen mineralization,and aboveground plant growth to experimental ecosystem warming 显示文摘 | Rustad L E Campbell J L Marion G M etal | 2001 | Oecologia2001，126，4： | 1 |
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