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| 1 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 2 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 3 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 4 | Solid phase extraction and high performance liquid chromatographic determination of doxophylline in plasma显示文摘 | Lagana A Bizzarri M Marino A | 1990 | Biomed Chromatogr1990，4，5： | 2 |
| 5 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 6 | More about singular line graphs of trees显示文摘 | MARINO M C SCIRIHA I SIMIC S K | 2006 | Publications De L''Institut Mathematique Nouvelle serie2006，79，93： | 1 |
| 7 | Reliability programming in reservoir manage显示文摘 | Marino M A | 1982 | Water Resources Research1982，，4： | 1 |
| 8 | Primary bílateral adrenal B-cell lymphoma associated with EBV and JCV infection显示文摘 | Barzon L Trevisan M Marino F | 2009 | Infect Agent Cancer2009，4，4： | 1 |
| 9 | Epidemiology of non-alco- holic fatty liver disease 显示文摘 | Bellentani S Scaglioni F Marino M | 2010 | J Dig Dis2010，28，1： | 1 |
| 10 | Catecholamine production and tyrosine hydroxylase expression in peripheral blood mononuclear cells from multiple sclerosis patients:effect of cell stimulation and possible relevance for activation-induced apoptosis显示文摘 | Cosentino M Zaffaroni M Marino F | 2002 | J Neuroimmunol2002，133，： | 1 |
| 11 | Sympathetic storming in a patient with intracranial basal ganglia hemorrhage显示文摘 | Siu G Marino M Desai A | 2011 | Am J Phys Med Rehabil2011，90，3： | 1 |
| 12 | Grapefruit juice reduces theoral bioavailability of fexofenadine but not desloratadine显示文摘 | Banfield C Gupta S Marino M | 2002 | ClinPharmacokinet2002，41，： | 1 |
| 13 | Phenylselenenyl sulfate induced cyclization of allylhydrazines, synthesis of pyrazole derivatives显示文摘 | Tiecco M Testaferri L Marino F | 1997 | Tetrahedron1997，53，12： | 1 |
| 14 | Strategies and Metric for Resili- ence in Computer Networks 显示文摘 | Salles R M Marino D A J R | 2011 | The Computer Journal Ad- vance Access published2011，2011，： | 1 |
| 15 | Diagnostic utility of thyroglobulin detection in fine-needle aspiration of cervical cystic metastatic lymph nodes from papillary thyroid cancer with negative cytology显示文摘 | Cignarelli M Ambrosi A Marino A | 2003 | Thyroid2003，13，： | 1 |
| 16 | Digital control and simulation for power electronic apparatus in dualvoltage railway locomotive 显示文摘 | Busco B Marino P Porzio M | 2003 | IEEE Transactions on Power Electronics2003，18，5： | 1 |
| 17 | Acute and severe liver damage associated with intravenous glucocorticoid pulse the rapy in patients with Graves ophthalm opathy 显示文摘 | Marino M Morabito E Bmnetto MR | 2004 | Thyroid2004，14，5： | 1 |
| 18 | Applicability of the geological strength index(GSI) classification for very weak and sheared rock masses显示文摘 | Hoek E Marinos P Benissi M | 1998 | Geology Environment1998，57，2： | 1 |
| 19 | Membrane association of estrogen receptor alpha and beta influences 17beta-estradiolmediated cancer cell proliferation显示文摘 | Marino M Ascenzi P | 2008 | Steroids2008，73，910： | 1 |
| 20 | Efficacy of lamivudine to prevent hepatitis reactivation in hepatitis B virusinfected patients treated for non-Hodgkin lymphoma 显示文摘 | Persico M De Marino F Russo GD | 2002 | Blood2002，99，2： | 1 |
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