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| 1 | 二氢乳清酸脱氢酶介导的铁死亡防御是肿瘤治疗中的潜在靶点显示文摘铁死亡是一种过度的脂质过氧化诱导的调节性细胞死亡形式,是关键的肿瘤抑制机制。谷胱甘肽过氧化物酶4(GPX4)和铁死亡抑制蛋白1(FSP1)构成了2个主要的铁死亡防御系统。本研究表明用GPX4抑制剂治疗癌细胞会导致N-氨基甲酰基-l-天冬氨酸(一种嘧啶生物合成中间体)的急性消耗,并伴随尿苷的积累。 | 李娜(编译) Mao C Liu X Zhang Y | 2021 | 国际老年医学杂志2021，42，4： | 69 |
| 2 | Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence显示文摘AIM: To study the correlation between the patterns of subcellular expression of p16 and CDK4 in colorectal epithelia in the normal-adenoma-carcinoma sequence. METHODS: Paraffin sections of 43 cases of normal colorectal epithelia and corresponding adenomas as well as carcinomas were analysed immunocytochemically for subcellular expression of p16 and CDK4 proteins. RESULTS: Most carcinomas showed more cytoplasmic overexpression for p16 and CDK4 than the adenomas from which they arised or the adjacent normal mucosa. Most normal or non-neoplastic epithelia showed more p16 and CDK4 expression in the nucleus than their adjacent adenomas and carcinomas. There was a significant difference between the subcellular expression pattern of p16 and CDK4 in normal-adenoma-carcinoma sequence epithelia (P < 0.001). Neither p16 nor CDK4 subcellular patterns correlated with histological grade or Dukes’ stage. CONCLUSION: Interaction of expression of p16 and CDK4 plays an important role in the Rb/p16 pathway. Overexpression of p16 and CDK4 in the cytoplasm, as well as loss expression of p16 in the nucleus might be important in the evolution of colorectal carcinoma from adenoma and, of adenoma from normal epithelia. | PO Zhao Xin Mao Ian C Talbot | 2006 | World Journal of Gastroenterology2006，12，39： | 5 |
| 3 | Microscopic colitis:A large retrospective analysis from a health maintenance organization experience显示文摘AIM:To examine the demographic data on a large multi-ethnic population of patients with microscopic colitis (MC) in Southern California and to determine the association of MC with inflammatory bowel disease (IBD) and colorectal cancer.METHODS: All patients diagnosed with MC by colonic biopsy from 1996-2005 were identified utilizing a pathology database. All biopsies were reviewed by experienced pathologists utilizing standard histologic criteria. Patients' medical records were reviewed and data regarding patient age, co-morbidities, sex, ethnicity, and medications were analyzed. An age-and sexmatched standard control group was also generated. Chi-square test was used to evaluate the associations of co-morbidities between lymphocytic colitis (LC), collagenous colitis (CC) and the control group.RESULTS: A total of 547 cases of MC were identif ied,376 patients with LC and 171 patients with CC. The female/male ratio was 3:1 in CC and 2.7:1 in LC patients. Celiac disease (P<0.001), irritable bowel syndrome (IBS) (P<0.001), and thyroid diseases (P<0.001) were found to have a higher occurrence in MC compared to the control group. No statistical differences in the occurrence of colorectal cancer, diabetes and IBD were found between the MC group and the control group.CONCLUSION: This is the largest group of patients with MC known to the authors that has been studied to date. Conditions such as celiac disease, IBS, and thyroid diseases were found to be related to MC. Furthermore, neither an increased risk of colorectal cancer nor IBD was associated with MC in this study. | Kevin T Kao Benito A Pedraza Amy C McClune David A Rios Yi-Qiong Mao Robert H Zuch Michael H Kanter Sony Wirio Chris N Conteas | 2009 | World Journal of Gastroenterology2009，15，25： | 5 |
| 4 | Raman Scattering Studies of the GeS2-Ga2 S3-CsCl Glassy System显示文摘 | H Z Tao X J Zhao C B Jing H Yang,S Mao | | 0，，： | 2 |
| 5 | Competition between radiation damping and transverse relaxation effects on NMR signal intensities 显示文摘 | Mao X A Guo J X Ye C H | 1994 | Chem Phys Lett1994，218，： | 2 |
| 6 | Standard CMOS implementation of a novel, fully differential optoelectronic integrated receiver 显示文摘 | YU C L MAO L H XIAO X D | 2009 | J of Optoelectronics Laser2009，20，4： | 1 |
| 7 | Influence of the addition of CeO2 on the microstructure and the magnetic properties of yttrium iron garnet ceramic 显示文摘 | Mao T C Chen J C | 2006 | J Magn Magn Mater2006，302，： | 1 |
| 8 | Influence of wavelength on fractionation in laser ablation ICP-MS 显示文摘 | Russo R E Mao X L Borisov 0 V Liu H C | 2000 | Journal of Analytical Atomic Spectrometry2000，15，： | 1 |
| 9 | Development of fetal brain renin-angiotensin system and hypertension programmed in fetal origins 显示文摘 | Mao C Shi L Xu F | 2009 | Neurobiology2009，87，4： | 1 |
| 10 | The application of competitive hopfield neural network to medical image segmentation显示文摘 | CHENG K S LIN J S MAO C W | 1996 | IEEE T Med Imaging1996，15，4： | 1 |
| 11 | The dynamically coursing processes of the microstructures in the nondendritic AlSi7Mg alloy remelted in the semi-solid state 显示文摘 | Mao W M Cui C L Zhao A M | 2000 | Trans Nonferrous Met Soc China2000，10，1： | 1 |
| 12 | Models of capital budgeting,E-V versus E-S显示文摘 | Mao J C T | 1970 | Journal of Financial and Quantitative Analysis1970，5，： | 1 |
| 13 | Re-Os isotopic dating of molybdenites in the Xiaoliugou W (Mo) deposit in the northern Qinling mountains and its geological significance显示文摘 | Mao J W Zhang Z C Zhang Z H | 1999 | Geochim Cosmochim Acta1999，36，： | 1 |
| 14 | A symmetric image encryption scheme based on 3D chaotic cat maps显示文摘 | CHEN G R MAO Y B CHUI C K | 2004 | Chaos Solitons and Fractals2004，21，3： | 1 |
| 15 | A new preconcentra?tion method for platinum and gold based on a macropore anion resin HHY-IOA显示文摘 | Li C Chai C Yang X Hou X Mao X | 1997 | Talanta1997，44，7： | 1 |
| 16 | Fluorescent carbon nanoparticles derived from candle soot 显示文摘 | Liu H Ye T Mao C | 2007 | Angew Chem Int Ed Engl2007，46，34： | 1 |
| 17 | Statistical Pattern Recognition: A Review显示文摘 | Jain A K Duin R P W Mao J C | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence2000，22，1： | 1 |
| 18 | Effect of high polymerization temperature on the microstructure of isotactic polypropylene prepared using heterogeneous TiC1JMgCI2 catalyst 显示文摘 | Zhong C F Mao Bingquan Gao Mingzhi | 2003 | Journal of Applied Polymer Science2003，90，： | 1 |
| 19 | A multiphase model for cold start of polymer electrolyte fuel cells显示文摘 | MAO L WANG C Y TABUCHI Y | 2007 | J of the Electrochemical Society2007，154，3： | 1 |
| 20 | Oriented Nucleation of Hydrox- ylapatite Crystals on Spider Dragline Silks显示文摘 | CAO B R MAO C B | 2007 | Lang- muir2007，23，10： | 1 |
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