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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 3 | The mental representation of spatial descriptions显示文摘 | Mani K Johnson-Laird P N | 1982 | Memory & Cognition1982，10，2： | 1 |
| 4 | Morphological and functional changes during thyroid hyperplasia and involution in C3H Mice:evidence for folliculoneogenesis during involution显示文摘 | MANY MC DENEF JF GATHY P | 1983 | Endocrinology1983，112，4： | 1 |
| 5 | Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice显示文摘 | Sidhu G S Mani H Gaddipati J P | 1999 | Wound Repair and Regeneration1999，7，5： | 1 |
| 6 | Region - based adaptive sli- cing显示文摘 | Mani K Kulkarni P | 1999 | Computer Aided Design1999，31，5： | 1 |
| 7 | Pyrolysis and combustion kinetics of Fosterton oil using thermogravimetric analysis显示文摘 | MURUGAN P MAHINPEY N MANI T | 2009 | Fuel2009，88，9： | 1 |
| 8 | Evaluation of hypoglycemic activity of inorganic constituents in Nelumbo nucifera seeds on streptozotocin-induced diabetes in rats显示文摘 | MANI S S SUBRAMANIAN I P PILLAI S S | 2010 | Biological Trace Element Research2010，138，3： | 1 |
| 9 | Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways显示文摘 | Onder T T Gupta P B Mani S A | 2008 | Cancer Research2008，68，10： | 1 |
| 10 | Effect of iron and molybdenum on yield and nutrition of horsegram in a red loamy sand soil 显示文摘 | DURAISAMY P MANI A K | 2001 | Indian Journal of Dryland Agricultural Research and Development2001，16，2： | 1 |
| 11 | Influence of proteins on the hydrothermal gasification and liquefaction of biomass (2): Model compounds 显示文摘 | Kruse A Mani P Spieler F | 2006 | Industrial & Engineering Chemistry Research2006，6，1： | 1 |
| 12 | Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract显示文摘 | Mani V Kumar K G Milind P | 2007 | Jourmd of Ethnopharmacology2007，109，： | 1 |
| 13 | Loss of E-cadherin promotes metastasis via multiple downstream transcriptional path- ways显示文摘 | ONDER T T GUPTA P B MANI S A | 2008 | Cancer Res2008，68，10： | 1 |
| 14 | Region-based adaptive slic- ing显示文摘 | Mani K Kulkarni P Dutta D | 1999 | Computer-Aided Design1999，31，5： | 1 |
| 15 | How scaf- folding nurtures the development of young children's lit- eracy repertoire: insiders ' and outsiders' collaborative understanding 显示文摘 | Henderson S D Many J E Wellbom H P | 2002 | Reading Research and Institution2002，41，4： | 1 |
| 16 | Picroliv preconditioning protects the rat liver against ischemia-reperfusion injury显示文摘 | Singh AK Mani H seth P | 2000 | Eur J Pharmacol2000，395，3： | 1 |
| 17 | Region-based adaptive slicing显示文摘 | MANI K KULKARNI P DUTTA D | 1999 | Computer Aided Design1999，31，5： | 1 |
| 18 | Analysis of bio-oil,biogas,and biochar from pressurized pyrolysis of wheat straw using a tubular reactor显示文摘 | MAHINPEV N MURUGAN P MANI T RAINA R | 2009 | Energy Fuels2009，23，5： | 1 |
| 19 | Management of mu- nicipal solid wastes and production of liquid biofertilizer through vermic activity of epigeic earthworm Eisenia fetida 显示文摘 | Mishra K Singh K Mani Tripathi C P | 2014 | International Journal of Recycling of Organic Waste in Agriculture2014，3，3： | 1 |
| 20 | Systemic acquired resistance显示文摘 | Sticher L Mani B Metraux J P | 1997 | Annual Review of Phytopathology1997，35，： | 1 |
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