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| 1 | Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process显示文摘Aging is a dynamic and progressive process that begins at conception and continues until death.This process leads to a decrease in homeostasis and morphological,biochemical and psychological changes,increasing the individual’s vulnerability to various diseases.The growth in the number of aging populations has increased the prevalence of chronic degenerative diseases,impairment of the central nervous system and dementias,such as Alzheimer’s disease,whose main risk factor is age,leading to an increase of the number of individuals who need daily support for life activities.Some theories about aging suggest it is caused by an increase of cellular senescence and reactive oxygen species,which leads to inflammation,oxidation,cell membrane damage and consequently neuronal death.Also,mitochondrial mutations,which are generated throughout the aging process,can lead to changes in energy production,deficiencies in electron transport and apoptosis induction that can result in decreased function.Additionally,increasing cellular senescence and the release of proinflammatory cytokines can cause irreversible damage to neuronal cells.Recent reports point to the importance of changing lifestyle by increasing physical exercise,improving nutrition and environmental enrichment to activate neuroprotective defense mechanisms.Therefore,this review aims to address the latest information about the different mechanisms related to neuroplasticity and neuronal death and to provide strategies that can improve neuroprotection and decrease the neurodegeneration caused by aging and environmental stressors. | Mariana Toricelli Arthur Antonio Ruiz Pereira Guilherme Souza Abrao Helena Nascimento Malerba Julia Maia Hudson Sousa Buck Tania Araujo Viel | 2021 | Neural Regeneration Research2021，16，1： | 8 |
| 2 | Sectoral systems of innovation and production显示文摘 | Franco Malerba | 2002 | Research Policy2002，，2： | 4 |
| 3 | Technological entry, exit and survival: an empirical analysis of patent data显示文摘 | Franco Malerba Luigi Orsenigo | 1999 | Research Policy1999，，6： | 2 |
| 4 | Innovation and the dynamics and evolution of industries: Progress and challenges显示文摘 | Malerba F | 2007 | International Journal of Industrial Organization2007，25，： | 1 |
| 5 | Influence of dif- ferent chemical elements on irradiation-induced hardening embrittlement of RPV steels 显示文摘 | Lambrecht M Malerba L Almazouzi A | 2008 | Journal of Nuclear Ma- terials2008，378，3： | 1 |
| 6 | Diodovich C Inhibition of CFU-E/BFU-E and CFU-GM colony growth by cyclophosphamide,5-fluorou-racil and taxol:development of a high-throughput in vitromethod显示文摘 | Malerba I Casati S Diodovich C | 2004 | Toxicol In Vitro2004，18，3： | 1 |
| 7 | Ambroxol in the 21 st century : pharmacologi- cal and clinical update显示文摘 | Malerba M Ragnoli B | 2008 | Expert Opinion on Drug Metabolism & Toxicology2008，4，： | 1 |
| 8 | The potential therapeutic role of potassium channel modulators in asthma and chronic obstructive pulmo- nary disease 显示文摘 | MALERBA M RADAELI A MANCUSO S | 2010 | J Biol Regul Homeost Agents2010，24，2： | 1 |
| 9 | Human colon cancerepithelial cells harbour active HEDGEHOG-GLI signalling thatis essential for tumour growth, recurrence, metastasis and stemcell survival and expansion 显示文摘 | Varnat F Duquet A Malerba M | 2009 | EMBO Mol Med2009，1，67： | 1 |
| 10 | Demand, innovation, and the dynamics of market structure : The role of experimental users and diverse preferences 显示文摘 | MALERBA F NELSON R | 2007 | J Evol Econ2007，17，： | 1 |
| 11 | A comparative analysis of methods for pruning decision tree显示文摘 | Floriana Esposito Donato Malerba Giovanni Semeraro | 1997 | IEEE Tranactions of Pattern Analysis and Machine Intelligence1997，19，5： | 1 |
| 12 | Optimizing antisense oligonucleotides using phosphorodiamidate morpholino oli gomers显示文摘 | Popplewell L J Malerba A Dickson G | 2012 | Methods Mol Biol2012，867，： | 1 |
| 13 | FADS genotypes and de saturase activity estimated by the ratio of arachidonic acid to lino leic acid are associated with inflammation and coronary artery dis ease显示文摘 | Martinelli N Girelli D Malerba G | 2008 | Am J Clin Nutr2008，88，4： | 1 |
| 14 | Platelet activation as a novel mechanism of atherothrombotic risk in chronic obstructive pulmonary disease 显示文摘 | Malerba M Clini E Malagola GC | 2013 | Expert Rev Hematol2013，6，4： | 1 |
| 15 | Innovation, industrial dynamics and structural transformation: Schumpeterian legacies显示文摘 | Franco Malerba Uwe Cantner | 2006 | Journal of Evolutionary Economics (-)2006，，1： | 1 |
| 16 | Technological regimes and sec- toral patterns of innovative activities显示文摘 | Malerba F Orsenigo L | 1997 | Industrial and Corporate Change1997，6，1： | 1 |
| 17 | Demand,innovation,and the dynamics of market structure:The role of experimental users and diverse preferences显示文摘 | Franco Malerba Richard Nelson Luigi Orsenigo Sidney Winter | | 0，，17： | 1 |
| 18 | Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth,recurrence,metastasis and stem cell survival and expansion显示文摘 | Varnat F Duquet A Malerba M | 2009 | EMBO Mol Med2009，1，67： | 1 |
| 19 | Schumpeterian Patterns of Innovative Activity in the ICT Field显示文摘 | Corrocher N Malerba F Montobbio F | 2007 | Research Policy2007，，3： | 1 |
| 20 | In vitro tests to e- valuate immunotoxicity : a preliminary study 显示文摘 | CARFI M GENNARI A MALERBA I | 2007 | Toxicology2007，229，12： | 1 |
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