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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Leaf area index estimation with MODIS reflectance time series and model inversion during full rotations of Eucalyptus plantations显示文摘 | Maire G Marsden C Verhoef W | 2011 | Remote Sensing of Environment2011，115，2： | 1 |
| 3 | Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke显示文摘 | Weir C J Mair S W Waters M R | 2003 | Stroke2003，34，8： | 1 |
| 4 | Relationship between natriuretic peptides and hemodynamics in patients with heart failure at rest and after ergometric exercise显示文摘 | Friedl W Mair J Thomas S | 1999 | Clin Chim Acta1999，281，12： | 1 |
| 5 | Porosity measurement and the effects of finite pulse widths on xenon gas diffusion NMR studies of porous media显示文摘 | Mair R W | 2001 | Magnetic Resonance Imaging2001，，19： | 1 |
| 6 | Natriuretic peptides in assessment of left ventricular dysfunction 显示文摘 | Mair J Friedl W Thomas S | 1999 | Scand J Clin Lab Invest Suppl1999，230，： | 1 |
| 7 | Frequency of rib and sternum fractures associated with out-of hospital cardiopulmonary resuscitation is underestimated by conventional chest X ray显示文摘 | Lederer W Mair D Rabl W | 2004 | Resuscitation2004，60，2： | 1 |
| 8 | Natriuretic peptides in assessment of left ventricular dysfunction显示文摘 | Mair'J Friedl W Thomas | 1999 | Scand J Clin Lab Invest Suppl1999，230，： | 1 |
| 9 | Decline in perfluornoctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000--2006 显示文摘 | Olsen G W Mair D C Church T R | 2008 | Environmental Science & Technology2008，42，13： | 1 |
| 10 | The role of physical therapy in the rehailitation of patients with mastectomy and breast reconstruction 显示文摘 | Maire B Anaw M Kaye W | 2002 | Breast Disease2002，16，： | 1 |
| 11 | Magnetic resonance spectroscopy of memory and frontal brain region in early multiple sclerosis 显示文摘 | Staffen W Zauner H Mair A | 2005 | J Neuropsychiatry Clin Neurosci2005，17，3： | 1 |
| 12 | Natriuretic peptides in assessment of left ventricular dysfunction显示文摘 | Friedl W Thomas S | 1999 | Scand J Clin Lab Invest1999，230，： | 1 |
| 13 | The pathology of spinal cord lesions and their relation to the clinical features in protrusion of cervical intervertebral discs: a report of four cases 显示文摘 | Mair W G P Druckmen R | 1953 | Brain1953，76，： | 1 |
| 14 | Leaf Area Index Esti mation with MODIS Reflectance Time Series and Model In version during Full Rotations of Eucalyptus Plantations显示文摘 | Maire G Marsden C Verhoef W | 2011 | Remote Sensing of Environment2011，115，2： | 1 |
| 15 | Natfiutetic peptldes in assessment of Left- Ventricular dysfunction 显示文摘 | Mair J Friedl W Thomas S | 1999 | Scand din Invest1999，，： | 1 |
| 16 | Measuring the progession of idiopathic Parkinson disease with -beta-CIT SPECT显示文摘 | Staffen W Mair A Unterrainer J | 2000 | J Neural Transm2000，107，5： | 1 |
| 17 | Centrifugemodelling of tunnelling near driven piles显示文摘 | JACOBSZ S W STANDING J R MAIR R J | 2004 | Soils andFoundations2004，44，1： | 1 |
| 18 | Relationship between natriuretic peptides and hemodynamics in patients with heart failure at rest and after ergometric exercise显示文摘 | FRIEDL W MAIR J THOMAS S | 1999 | Clin Chim Acta1999，81，12： | 1 |
| 19 | Centrifuge modelling of tunnelling near driven piles显示文摘 | JACOBSZ S W STANDING J R MAIR R J | 2004 | Soils and Foundation2004，44，1： | 1 |
| 20 | Ca isotope variations in Allende显示文摘 | JUNGCK M H A SHIMAMURA T LUG- MAIR G W | 1984 | Geochim Cosmochim Acta1984，48，12： | 1 |
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