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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 3 | identification of the 72- kDa(MMP - 2)and 92 - kDa(MMP - 9)gelatinase type iv collar - genase in preparations of laminin and Matrigel 显示文摘 | Mackay A R Gomez D E Cottam D W | 1993 | Biotech - niques1993，15，： | 1 |
| 4 | Real-time PCR in Virology 显示文摘 | Mackay I M Arden K E Nitsche A | 2002 | Nucleic Acids Res2002，30，6： | 1 |
| 5 | A Frame-work for classifying and quantifying the natural, capital, and e- cosystem services of soils显示文摘 | DOMINATI E PATTERSON M MACKAY A | 2010 | Ecological Economics2010，69，： | 1 |
| 6 | Effects of distribution-based pa- rameter aggregation on a spatially distributed agricultural nonpoint source pollution model 显示文摘 | Chen E Mackay D S | 2004 | Journal of Hydrolo- gy2004，295，1： | 1 |
| 7 | The non-structural polyprotein 3ABC of foot-and mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | Diego M D Brocchi E Mackay D | 1997 | Arch Virol1997，142，： | 1 |
| 8 | Real-time PCR in virology显示文摘 | Mackay I M Arden K E Nitsche A | | 0，，06： | 1 |
| 9 | Real-time PCR in virology 显示文摘 | Mackay I M Arden K E Nitsche A | 2002 | Nucleic Acids Res2002，30，6： | 1 |
| 10 | Advanced oxidation processes for organic contaminant destruction based on the Fenton reaction and related chemistry 显示文摘 | PIGNATELLO J J OLIVEROS E MACKAY A | 2006 | Crit Rev Environ Sci Technol2006，36，1： | 1 |
| 11 | Chemorheology of thermoset-an overview 显示文摘 | Halley P J Mackay M E | 1996 | Polymer Engineering and Science1996，36，5： | 1 |
| 12 | Comparison of transient thermal conduction in tellurium and organic dye based digital optical storage media显示文摘 | Burgess A N Evans K E Mackay M | 1987 | J Appl Phys1987，61，： | 1 |
| 13 | Investment and competition显示文摘 | Akdogu E Mackay P | 2008 | Journal of Financial Quantitative Analysis2008，43，： | 1 |
| 14 | Chemorheology of t her mal: An overview显示文摘 | all ey P J Mackay M E | 1996 | Poly mer Engineeri ng and Science1996，36，5： | 1 |
| 15 | General strategies for nanoparticle dispersion 显示文摘 | MACKAY M E TUTEJA A PHILLIP M | 2006 | Scierce2006，311，5768： | 1 |
| 16 | Chemorheology of thermosets-An overview 显示文摘 | Halley P J Mackay M E | 1996 | Polym Eng Sci1996，36，5： | 1 |
| 17 | The nonstrucrural protein 3ABC of foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | De Diego M Brocchi E Mackay D | 1997 | Arch Virol1997，142，10： | 1 |
| 18 | Effects of distribution-based parameter aggregation on a spatially distributed agricultural non-point source pollution model显示文摘 | Chen E Mackay D S | 2004 | Journal of Hydrology2004，295，14： | 1 |
| 19 | Turbulent Mixingand Exchange with Interior Waters on Sloping Boundaries显示文摘 | Kunze E MacKay C McPhee-Shaw E E | 2012 | Journal of Physical Oceanography2012，42，6： | 1 |
| 20 | The gel and rheological behaviour of radiation-crosslinked linear low-density polyethylene显示文摘 | Halley P J Mackay M E | 1994 | Polymer1994，35，10： | 1 |
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