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| 1 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 2 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 3 | Corrosion of Alloy Steel in 30% Ethylene Glycol Solution and CrO_4^(2-) Under Hydrodynamic Condition显示文摘The electrochemical behavior of steel alloy in 30%ethylene glycol-water solution at different solution rotating speeds was investigated by polarization curves and AC impedance measurements.The results obtained showed that corrosion rate did not change significantly at different rotating speeds.The effect of chromate as the inhibitor was studied and high inhibition efficiency was obtained.It was found that surface passivation occurred in the presence of the inhibitor.The inhibiting effect of the chromate was explained on the basis of the competitive adsorption between the inorganic anions and the aggressive Cl-and the adsorption isotherm basically obeys the Langmuir adsorption isotherm.Thermodynamic parameters for inhibitor adsorption were determined and results reveal that the adsorption process is spontaneous. | M Niknejad Khomami I Danaee A A Attar M Peykari | 2013 | Journal of Iron and Steel Research(International)2013，20，6： | 3 |
| 4 | Disease dependent qualitative and quantitative differences in the inflammatory response to ascites occurring in cirrhotics显示文摘AIM:To assess differing patterns and levels of ascitic fluid cyctokine and growth factors exist between those with a high risk and low risk of spontaneous bacterial peritonitis(SBP). METHODS: A total of 57 consecutive patients with ascites requiring a large volume paracentesis were studied. Their age, gender, specific underlying disease conditions were recorded after a review of their clinical records. Each underwent a routine assessment prior to their paracentesis consisting of a complete blood count, complete metabolic profile and prothrombin time/international normalized ratio(INR) determination. The ascitic fluid was cultured and a complete cellcount and albumin determination was obtained on the fluid. In addition, blood and ascitic fluid was assessed for the levels of interleukin interleukin(IL)-1A, IL-1B, IL-2, IL-4, IL-8, IL-10, monocyte chemotactic protein(MCP)-1, tumor necrosis factor(TNF)-α, interferon(IFN)-γ, vascular endothelial growth factor(VEGF) and epidermal growth factor(EGF) utilizing the Randox Biochip platforms(Boston, MA). A serum-ascites gradient, for each cytokine and growth factor was calculated. The results are reported as mean ± SEM between disease groups with statistical analysis consisting of the student t-test(two tailed) with a P value of 0.05 defining significance. RESULTS: No clinically important demographic or biochemical differences between the 4 groups studied were evident. In contrast, marked difference in the cytokine and growth factors levels and pattern were evident between the 4 disease groups. Individuals with alcoholic cirrhosis had the highest levels of IL-1A, IL-1B, IL-4, IFNγ. Those with malignant disease had the highest levels of IL-2. Those with hepatitis C virus(HCV) associated cirrhosis had the highest value for IL-6, IL-8, IL-10, MCP-1 and VEGF. Those with cardiac disease had the highest level of TNF-α and EGF. The calculated serum- ascites gradients for the cardiac and malignant disease groups had a greater frequency of negative values signifying greater levels of IL-8, IL-10 and MCP-1 in ascites than did those with alcohol or HCV disease. CONCLUSION: These data document important differences in the cytokine and growth factor levels in plasma, ascitic fluid and the calculated plasma- ascites fluid gradients in cirrhotics requiring a large volume paracentesis. These differences may be important in determining the risk for bacterial peritonitis. | Bashar M Attar Magdalena George Nicolae Ion-Nedelcu Guilliano Ramadori David H Van Thiel | 2014 | World Journal of Hepatology2014，6，2： | 3 |
| 5 | Interference-limited resource allocation for cognitive radio in orthogonal frequency -division multiplexing networks显示文摘 | Attar A Holland O Nakhai M R | 2008 | IET Commun2008，，2： | 1 |
| 6 | MicroRNA 17-92 expressed by a transposon-based vector changes expres- sion level of cell-cycle-related genes 显示文摘 | Attar M Arefian E Nabiuni M | 2012 | Cell Biology International2012，36，11： | 1 |
| 7 | Resveratrol regulates cellular PKC α and δto inhibit growth and induce apoptosis in gastric cancer cells 显示文摘 | Atten M J Godoy - Romero E Attar BM | 2005 | Investigational New Drugs2005，23，： | 1 |
| 8 | Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase C-mediated mechanism显示文摘 | ATTEN M J ATTAR B M MILSON T | 2001 | Biochem Pharm2001，62，10： | 1 |
| 9 | Extra-articular manifestationsof rheumatoid arthritis:a hospital-based study显示文摘 | Al-Ghamdi A Attar S M | 2009 | AnnSaudi Med2009，29，： | 1 |
| 10 | Solar water heating systems feasibility for domestic requests in Tunisia : Thermal potential and economic analysis 显示文摘 | Hazami M Naili N Attar I | 2013 | Energy Conversion and Management Elsevier Ltd2013，76，： | 1 |
| 11 | Discovery of BMS 536924, a small molecule inhibitor of IGF-I R with broad spectrum in vivo activity 显示文摘 | Wittman M Carboni J Attar R | 2005 | Amer Chem Soc2005，229，： | 1 |
| 12 | Synthesis and characterization of Anatase and Ruffle TiOz nanorods by template-sssisted method显示文摘 | Sadeghzadeh Attar A Sasani Ghamsari M Hajies- maeilbaigi F | 2008 | J Mater Sci2008，43，： | 1 |
| 13 | Another approach in analysis of paint coatings with EIS measurement: Phase angle at high frequencies 显示文摘 | Mabdavian M Attar M | 2006 | Corrosion Science2006，48，12： | 1 |
| 14 | Gastric Iipoma with Severe Hemorrhage显示文摘 | Myint M Atten MJ Attar BM | 1996 | Am J Gastroenterol1996，91，4： | 1 |
| 15 | Discovery of BMS-641988 ,a novel and potent inhibitor of androgen receptor signaling for the treatment of prostate cancer 显示文摘 | ATTAR R M JURE-KUNKEL M BALOG A | 2009 | Cancer Res2009，69，16： | 1 |
| 16 | Investigation on zinc phosphate effec- tiveness at different pigment volume concentrations via electro- chemical impedance spectro-scopy 显示文摘 | Mahdavian M Attar M M | 2005 | Eiectrochimica Acta2005，50，24： | 1 |
| 17 | Studying the influence of nano-Al2O3 particles on the cor- rosion performance and hydrolytic degradation resistance of an epoxy/polyamide coating on AA-1050 显示文摘 | GOLRU S S ATTAR M M RAMEZANZADEH B | 2014 | Progress in Organic Coatings2014，77，9： | 1 |
| 18 | BMS- 641988:a highly potent and rationally designed in- hibitor of the androgen receptor( AR), with efficacy in castration resistant human prostate cancer xeno- graft models显示文摘 | SALVATI M ATTAR R M BALOG A | 2008 | Ejc Suppl2008，6，12： | 1 |
| 19 | Effect of ZnO Nanoparticles on the Thermal and Mechanical Properties of Epoxy-based Nanocomposite显示文摘 | Ramezanzadeh B Attar M M Farzam M | 2011 | Journal of Thermal Analysis and Calorimetry2011，103，2： | 1 |
| 20 | Effect of ZnO nanoparticles on the thermal and mechanical proper- ties of epoxy-based nanocomposite显示文摘 | RAMEZANZADEH B ATTAR M M FARZAM M | 2011 | Journal of Thermal Analysis and Calorimetry2011，103，2： | 1 |
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