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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | Shift of path- ways during initiation of thermophilie methanogenesis at different initial pH显示文摘 | Hao L P LII F Li L Shao L M He P J | 2012 | Bioresour Technd2012，126，： | 1 |
| 3 | Degradation of starch by polarised light显示文摘 | Fiedorowicz M Tomasik P Lii C Y | 2001 | Carbohydrate Polymers2001，45，1： | 1 |
| 4 | Viscous Flow During Sah Welding显示文摘 | Wagner lII B H Jackson M P A | 2011 | Tectonophysics2011，510，34： | 1 |
| 5 | Degradation of starch by polarised light 显示文摘 | FIEDOROWICZ M TOMASIK P LII C Y | 2001 | Carbohydrate Polymers2001，45，1： | 1 |
| 6 | Intensity modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: Does IMRT increase the integral dose to normal brain? 显示文摘 | Hermanto U Frija E K Lii M J | 2007 | Int J Radiat Oncol Biol Phys2007，67，4： | 1 |
| 7 | Small covers over prisms 显示文摘 | Cai M Z Chen X Lii Z | 2007 | Topology Appl2007，154，： | 1 |
| 8 | Degradation of starch by polarised light显示文摘 | Fiedorowicz M Tomasik P Lii C Y | 2001 | Carbohydrate Polymers2001，45，1： | 1 |
| 9 | Recommender systems 显示文摘 | Lii Linyuan Medo M Yeung C H | 2012 | Physics Reports2012，519，1： | 1 |
| 10 | Novel Slow-Release Muhielement Compound Fertilizer with Hydroscopieity and Moisture Preservation 显示文摘 | Ni B Liu M Lii S | 2010 | Industrial & Engineering Chemistry Research2010，49，10： | 1 |
| 11 | Effects of granular structures on the pasting behaviors of starches显示文摘 | Tsai M L Li C F Lii C Y | 1997 | Cereal Chemistry1997，74，6： | 1 |
| 12 | Effect of Amy lose content on the rheological properties of rice starch显示文摘 | Lii C Tsai M Tseng K | 1996 | Cereal C hemi stry1996，73，4： | 1 |
| 13 | Spreading in online social networks:the role of social reinforcement显示文摘 | Zheng M H Lii L Y Zhao M | 2013 | Physical Review E2013，88，1： | 1 |
| 14 | A new robust narrowband active noise control system in the presence of frequency mismatch 显示文摘 | YEGUI X LIYING M KHORASANI K | 2006 | Audio Speech and Language Processing IEEE Transactions on2006，14，6： | 1 |
| 15 | Xanthan gum-gelatin complexes显示文摘 | Lii C Liaw S C Lai V M F | 2002 | European Polymer Journal2002，38，7： | 1 |
| 16 | Recommender Systems 显示文摘 | Lii L Medo M Yeung C H | 2012 | Physics Reports-Review Section of Physics Letters2012，519，1： | 1 |
| 17 | Target specificity analysis of the Abl kinase using peptide microarray data显示文摘 | Rychlewski L Kschischo M Dong Liying | 2004 | J Mol Biol2004，336，： | 1 |
| 18 | Doing right leads to doing well: When the type of CSR and reputation interact to affect consumer eval- uations of the firm显示文摘 | Lii Y S Lee M | 2012 | Journal of Business Ethics2012，105，1： | 1 |
| 19 | Effect of Amylose content on the rheological properties of rice starch显示文摘 | Lii C Tsai M Tseng K | 1996 | Cereal Chemistry1996，73，4： | 1 |
| 20 | Effect of amylose content on the rheological property of rice starch显示文摘 | LII C Y TSAI M L TSENG K H | 1996 | Cereal Chemistry1996，73，4： | 1 |
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