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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Measurement of fractional flow reserve to assess moderately severe coronary lesions: correlation with dobutamine stress echocardiography显示文摘 | Jimenez Navarro M Alonso Briales J H Hernandez Garcia M J | 2001 | J Interv Cardiol2001，14，5： | 2 |
| 3 | Urinary cadmium levels during pregnancy and postpartum:a longitudinal study 显示文摘 | Hernandez M Schuhmacher M Fernandez JD | 1996 | Biol Trace Elem Res1996，53，： | 2 |
| 4 | Resistance to Corrosion of galvanized steel covered with an epoxy-poly-amideprimer coating 显示文摘 | Gonzalez S Gil M A Hernandez J O | 2001 | ProgressinOrganicCoatings2001，41，： | 1 |
| 5 | Videothoracoscopic extrapleural insertion of Walter Lorenz Surgical bar for pectus excavatum 显示文摘 | Hernandez H Varela A Cordoba M | 2003 | J Thorac Cardiovasc Surg2003，126，6： | 1 |
| 6 | Echocardiographic evaluation of the Jarvik 2000 axial-flow LVAD显示文摘 | Croitoru M Hernandez A | 2005 | Tex Heart Inst J2005，32，3： | 1 |
| 7 | Efficacy and tolerability of budesonide/formoterol added to tiotropium in patients with chron- ic obstructive pulmonary disease 显示文摘 | Welte T Miravitlles M Hernandez P | 2009 | Am J Respir Crit Care Med2009，180，： | 1 |
| 8 | Bioremediation of soil degraded by sewage sludge:Effects on soil properties and erosion losses显示文摘 | ROS M HERNANDEZ M T GARCIA C | 2002 | Environmental Management2002，31，6： | 1 |
| 9 | Ultrasound-assisted Method for the Determination of Chemical Oxygen Demand显示文摘 | CANALS A HERNANDEZ M D R | 2002 | Analytical and Bioanalytical Chemistry2002，374，6： | 1 |
| 10 | Psychological distress among Latino family caregivers of adults with schizophrenia : The roles of burden and stigma raymond cortez显示文摘 | Sandy M Magaa Jorge I Ramirez Garcia Maria G Hernandez | 2007 | Psychiatric Services2007，58，3： | 1 |
| 11 | Diagnosis and treatment of submucous cleft palate: A review of 108 cases显示文摘 | Garcia-Velasco M Ysunza A Hernandez X | 1988 | Cleft Palate J1988，25，： | 1 |
| 12 | Differential response ofantioxidatlve enzymes of chloroplast and mitochondria to long-term NaClstress of pea plants显示文摘 | Gomez J M Hernandez J A Jimenez A | 1999 | Free Radical Res1999，31，： | 1 |
| 13 | Cardiomyocyte apoptosis and cardiac angiotensin converting enzyme in spontaneously hypertensive rats显示文摘 | Diez J Panio A Hernandez M | 1997 | Hypertension1997，30，5： | 1 |
| 14 | Dopa- mine abnormalities in the neocortex of patients with temporal lobe epi- lepsy 显示文摘 | Rocha L Alonso- Vanegas M Villeda- Hernandez J | 2012 | Neurobiol Dis2012，45，1： | 1 |
| 15 | The decline of the public in- tellectual in social work 显示文摘 | KARGER H J HERNANDEZ M T | 2004 | Sociology and Social Welfare2004，31，3： | 1 |
| 16 | Proposal of a hae-morheological profile for early detection of hypertensive gesta-tional disorders显示文摘 | Bollini A Hernandez G? Bravo Luna M | 2003 | Clin Hemorheol Microcirc2003，28，2： | 1 |
| 17 | The Measurement and Modeling of the Variation of Stemflow in a Laurel Forest in Tenerife,Canary Islands显示文摘 | ABOAL J R MORALES D HERNANDEZ M | 1999 | Journal of Hy-drology1999，221，： | 1 |
| 18 | Development of real-time PCR systems based on SYBR(R) Green I, Amplifluor (TM) and TaqMan (R) technologies for specific quantitative detection of the transgenie maize event GA21 显示文摘 | Hernandez M Esteve T Prat S | 2004 | J Cereal Sci2004，39，： | 1 |
| 19 | Prevalence and management of Schneiderian membrane perforations during sinus-lift procedures 显示文摘 | HERNANDEZ A F TORRADEFLOT M M MARTI C | 2008 | Clinical Oral Implants Research2008，19，1： | 1 |
| 20 | Injectable acrylic bone cements for vertebroplasty based on a radiopaque hydroxyapatite : formulation and rheological behaviour 显示文摘 | Hernandez L Gurruchaga M Goni I | 2009 | Mater Sci: Mater Med2009，20，1： | 1 |
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