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	题名	作者	年代	出处	被引量
1	Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH.	Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong	2022	Stroke & Vascular Neurology2022，7，1：	3
2	An assessment of testing-effort dependent software reliability growth models 显示文摘	HUANG C Y KUO S Y LYU M R	2007	IEEE Trans on Reliability2007，56，2：	1
3	A unified scheme of some nonhomogenous poisson process models for software reliability estimation显示文摘	HUANG C v LYU M R KUO S	2003	IEEE Transactions on Software Engineering2003，29，3：	1
4	Field emission from well-aligned zinc oxide nanowires grown at low temperature显示文摘	LEE C J LEE T J LYU S C	2002	Appl Phy Lett2002，81，18：	1
5	显示文摘	Lee C J Lyu T J	2002	Applied Physics Letters2002，81，：	1
6	Coalescence in Polymer Blends During Shearing 显示文摘	Lyu S Bates F Macosko C	2000	AIChE Journal2000，46，2：	1
7	Chnical role of bone marrow angiogenesis in childhood acute lymphocytic leukemia显示文摘	Lyu C J Rha S Y Won S C	2007	Yonsei Med J2007，48，2：	1
8	An assessment of testing-effort dependent software reliability growth models 显示文摘	IUANG C Y KUO S Y LYU M R	2007	IEEE Transactions on Reliability2007，56，2：	1
9	Predicting missing links via local information显示文摘	ZHOU T LYU L ZHANG Y C	2009	The European Physical Journal B2009，71，4：	1
10	Investigation of the mechanical properties and chemical resistance of PC/PBT/impact modifier blends 显示文摘	LYU M Y PAE Y NAH C	2003	Int Polym Proc2003，18，4：	1
11	Component ranking for fault-tolerant cloud applications显示文摘	ZHENG Z B ZHOU T C LYU M R	2012	IEEE Transactions on Services Computing2012，5，4：	1
12	Topoisomerase Ilbeta mediated DNA double-strand breaks: implications indoxorubicin cardiotoxicity and prevention by dexmzoxane显示文摘	Lyu Y L Kerrigan J E Lin C P	2007	Cancer Res2007，67，18：	1
13	Catalytic synthesis and photoluminescence of gallium nitride nanowires显示文摘	Lyu S C Cha O H Suh E K	2003	Chemical Physics Letters2003，，367：	1
14	Optimal release time for software systems considering cost,test-effort,and test efficiency显示文摘	HUANG C Y LYU M R	2005	IEEE Transaction on Reliability2005，54，4：	1
15	Effects of CaF2 and CaCI2 addition on the formation of llCaO ~ 7A1203 ~ CaS solid solution in the CaO-A1203 slag显示文摘	Lyu N N Yu J K Su C	2013	Metalurgia International2013，6，：	1
16	查看详情显示文摘	Lee C J Lee T J Lyu S C		0，，：	1
17	Germline stem cells and neo-oo- genesis in the adult human ovary显示文摘	LIU Y WU C LYU Q	2007	Developmental Biology2007，306，1：	1
18	Modeling of Coalescence in Polymer Blends 显示文摘	Lyu S Bates F Macosko C	2002	AIChE Journal2002，48，1：	1
19	Wnt-Ta up-regulates matrix metalloproteinase-12 ex- pression and promotes cell proliferation in corneal epithelial ceils dur- ing wound healing 显示文摘	Lyu J Joo C K	2005	J Biol Chem2005，280，21：	1
20	Eleetrophysiologieal features of Hirayama disease显示文摘	Lyu R K Huang Y C Wu Y R	2011	Muscle Nerve2011，44，2：	1

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