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| 1 | 基于流行病学、空间、基因组学数据的中国上海内部人口流动与结核病传播动力学研究显示文摘中国国内人口大规模从农村向城市流动,为结核病控制工作带来了新的挑战。2018年7月的《The Lancet. Infectious diseases》刊载了一项研究,旨在将基因组数据、空间数据和流行病学数据结合起来,描述有大量流动人口的城市环境中结核病的传播动力学特征。研究者们针对上海松江地区的培养阳性结核分枝杆菌开展了一项基于人群的研究。采用全基因组测序法,对具有相同"数目可变串联重复序列(VNTR)"组合的结核分枝杆菌表观基因簇进行了区分,并分析了居住距离与基因学成簇的结合分枝杆菌感染风险之间的关系。 | Yang C Lu L Warren JL | 2018 | 疾病监测2018，33，8： | 17 |
| 2 | Preliminary study on light hydrocarbons in ore-forming fluids of gold and antimony deposits in southwestern Guizhou, China显示文摘METAL minerals precipitate generally from ore-forming fluid. It is suggested that organic mat-ter in ore-forming fluid is one of the best media which show the role of organic matter in oregenesis. Because mineralizing temperatures of many ore deposits exceeded the stable rangesof liquid hydrocarbons, only light hydrocarbons were preserved well in inclusions. Thus, | Zhuang, HP Lu, JL Fu, JM Liu, JZ Shi, JX | 1997 | Chinese Science Bulletin1997，42，20： | 8 |
| 3 | Tojapride Reverses Esophageal Epithelial Inflammatory Responses on Reflux Esophagitis Model Rats显示文摘Objective To investigate the mechanism of Tojapride,a Chinese herbal formula extract,on strengthening the barrier function of esophageal epithelium in rats with reflux esophagitis(RE).Methods Ten out of 85 SD rats were randomly selected as the sham group(n10),and 75 rats were developed a reflux esophagitis model(RE)by the esophageal and duodenal side-to-side anastomosis.Fifty successful modeling rats were divided into different medicated groups through a random number table including the model,low-,medium-,and high-dose of Tojapride as well as omeprazole groups(n10).Three doses of Tojapride[5.73,11.46,22.92 g/(kg•d)]and omeprazole[4.17 mg/(kg•d)]were administrated intragastrically twice daily for 3 weeks.And the rats in the sham and model groups were administered 10 mL/kg distilled water.Gastric fluid was collected and the supernatant was kept to measure for volume,pH value and acidity.Esophageal tissues were isolated to monitor the morphological changes through hematoxylin-eosin(HE)staining,and esophageal epithelial ultrastructure was observed by transmission electron microscopy.The expressions of nuclear factor kappa-light-chain-enhancer of activated B cells p65(NF-KBp65),κB kinase beta(IKKß),occludin,and zonula occludens-1(ZO-1)in the esophageal tissues were measured by immunohistochemistry and Western blot,respectively.Results The gastric pH value in the model group was significantly lower than the sham group(P<0.05).Compared with the model group,gastric pH value in the omeprazole and medium-dose of Tojapride groups were significantly higher(P<0.05).A large area of ulceration was found on the esophageal mucosa from the model rats,while varying degrees of congestion and partially visible erosion was observed in the remaining groups.Remarkable increase in cell gap width and decrease in desmosome count was seen in RE rats and the effect was reversed by Tojapride treatment.Compared with the sham group,the IKKßlevels were significantly higher in the model group(P<0.05).However,the IKKßlevels were down-regulated after treatment by all doses of Tojapride(P<0.01 or P<0.05).The occluding and ZO-1 levels decreased in the model group compared with the sham group(Ps0.01 or Ps0.05),while both indices were significantly up-regulated in the Tojapride-treated groups(P<0.01 or P<0.05).Conclusions Tojapride could improve the pathological conditions of esophageal epithelium in RE rats.The underlying mechanisms may involve in down-regulating the IKKßexpression and elevating ZO-1 and occludin expression,thereby alleviating the inflammation of the esophagus and strengthening the barrier function of the esophageal epithelium. | YIN Xiao-lan ZHONG Linda LIN Cheng-yuan SHI Xiao-shuang ZHANG Jiao CHEN Zheng-yi CHE Hui MA Xiang-xue TIAN Ya-xin DUAN Yuan-zhi LU Lin Jl Hai-jie ZHAO Ying-pan TANG Xu-dong WANG Feng-yun | 2021 | Chinese Journal of Integrative Medicine2021，27，8： | 4 |
| 4 | Experimental study of gold distribution in the algae-organic matter-fluid system显示文摘THE previous simulating experiments show that many algae can greatly accumulate goldfrom solution under some conditions. Some other experiments further indicate that organ-ic matter and crude oil can also play an important role in gold geochemistry processes such asleaching, migration, reduction and precipitation. However, these biometallogeneses are | Xie, SC Yin, HF Wang, HM Zhou, XG Fu, JM Sheng, GY Zhang, HZ Lu, JL | 1997 | Chinese Science Bulletin1997，42，19： | 3 |
| 5 | Neuropsychiatric sym-ptoms are associated with progression from mild cognitive impairment to Alzheimer's disease显示文摘 | Teng E Lu PH Cummings JL | 2007 | Dement Geriatr Cogn Disord2007，24，4： | 1 |
| 6 | Mechanisims of myocardial reperfusion in - jury 显示文摘 | Park JL Lu chesi BR | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 7 | An unusual structural motif f antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides显示文摘 | Tam JP Lu YA Yang JL | 1999 | Proc Natl Acad Sci USA1999，96，16： | 1 |
| 8 | Adoptive transfer of T- cell precursors enhances T-cell reconstitution after aUogeneic hemato- poietic stem cell transplantation 显示文摘 | Zakrzewski JL Kochman AA Lu SX | 2006 | Nat Med2006，12，9： | 1 |
| 9 | Combinatorial modulation of galP and glk gene expression for improved alternative glucose utilization显示文摘 | Lu J Tang JL Liu Y | | 0，，06： | 1 |
| 10 | Functional and epige- netic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper ceils 显示文摘 | Lu KT Kanno Y Cannons JL | 2011 | Immunity2011，35，： | 1 |
| 11 | Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression显示文摘 | Lu L Song HF Wei JL | 2014 | Biochem Biophys Res Commun2014，443，： | 1 |
| 12 | Light-directed,spatially addressable parallel chemical synthesis显示文摘 | Fodor SP Read JL Pirrung MC Stryer L Lu AT Solas D | 1991 | Science1991，251，4995： | 1 |
| 13 | Educational diagnosis of self- management behaviors of parents with asthmatic children by tri- angulation based on PRECEDE-PROCEED model in Taiwan 显示文摘 | Chiang LC Huang JL Lu CM | 2003 | Patient Education and Counseling2003，49，1： | 1 |
| 14 | Total coumarins from Urtica dentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways显示文摘 | Wang J Lu JL Lan Y | 2013 | J Ethnopharmacol2013，146，1： | 1 |
| 15 | Hinge Atlas:relating protein sequence to sites of structural flexibility显示文摘 | Flores S C Lu L J Yang JL | 2007 | Bioinformatics2007，8，： | 1 |
| 16 | A new method for assessing variability of 24h blood pressure and its first application in 1526 elderly men显示文摘 | Duan JL Hao CN Lu W | 2009 | Clin Exp Pharmacol Physiol2009，36，： | 1 |
| 17 | Stepwise cumulation ofRUNX3 methylation mediated by Helicobacter pyloriinfection contributes to gastric carcinoma progression 显示文摘 | Lu XX Yu JL Ying LS | 2012 | Cancer2012，118，22： | 1 |
| 18 | Protective effect of green teapolyphenols against ultraviolet B -induced damage to HaCaT cells显示文摘 | Wu LY Zheng XQ Lu JL | 2009 | Hum Cell2009，22，1： | 1 |
| 19 | Stepwise cumulation of RUNX3methylation mediated by Helicobacter pylori infection contributes togastrin carcinoma progression 显示文摘 | Lu XX Yu JL Ying LS | 2012 | Cancer2012，118，22： | 1 |
| 20 | A new method for assessing variability of 24h blood pressure and its first application in 1526 elderly men显示文摘 | Duan JL Hao CN Lu W | 2009 | Clin Exp Pharmacol Physiol2009，36，11： | 1 |
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