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57篇 您的检索式：作者名="Loubani"

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	题名	作者	年代	出处	被引量
1	Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation?显示文摘Atrial fibrillation(AF)is the most common cardiac arrhythmia worldwide.The prevalence of the disease increases with age,strongly implying an age-related process underlying the pathology.At a time when people are living longer than ever before,an exponential increase in disease prevalence is predicted worldwide.Hence unraveling the underlying mechanics of the disease is paramount for the development of innovative treatment and prevention strategies.The role of voltage-gated sodium channels is fundamental in cardiac electrophysiology and may provide novel insights into the arrhythmogenesis of AF.Na_v1.5 is the predominant cardiac isoform,responsible for the action potential upstroke.Recent studies have demonstrated that Na_v1.8(an isoform predominantly expressed within the peripheral nervous system)is responsible for cellular arrhythmogenesis through the enhancement of pro-arrhythmogenic currents.Animal studies have shown a decline in Na_v1.5 leading to a diminished action potential upstroke during phase 0.Furthermore,the study of human tissue demonstrates an inverse expression of sodium channel isoforms;reduction of Na_v1.5 and increase of Na_v1.8 in both heart failure and ventricular hypertrophy.This strongly suggests that the expression of voltage-gated sodium channels play a crucial role in the development of arrhythmias in the diseased heart.Targeting aberrant sodium currents has led to novel therapeutic approaches in tackling AF and continues to be an area of emerging research.This review will explore how voltage-gated sodium channels may predispose the elderly heart to AF through the examination of laboratory and clinical based evidence.	Emmanuel Isaac Stephanie M Cooper Sandra A Jones Mahmoud Loubani	2020	World Journal of Cardiology2020，12，4：	3
2	Efficacy of transmyocardial laser revascularization and thoracic sympathectomy for the treatment of refractory angina显示文摘	Loubani M Sensky PR	2004	Ann Thorac Surg2004，78，1：	1
3	Coronary endarterectomy in the current era显示文摘	Tiruvoipati R Loubani M Peek G	2005	Curr Opin Cardiol2005，20，6：	1
4	Evidence, lack of evidence, controversy, and debate in the provision and performance of the surgery of acute type A aortic dissection 显示文摘	Bonser RS Ranasinghe AM Loubani M	2011	J Am Coil Cardiol2011，58，：	1
5	Safety and efficiacy of transplantation of autologous bone marrow into scarred myocardium for the enhancement of cardiac function in man显示文摘	Galinanes M Loubani M Davies J	2002	Circulation2002，106，：	1
6	The effect of gliclazide and glibenclamide on preconditioning of the human myocardium 显示文摘	Loubani M Fowler A Standen NB	2005	Eur J Pharmacol2005，515，：	1
7	Coronary endarterecto- my: impact on morbidity and mortality when combined with coro- nary artery bypass surgery显示文摘	Tiruvoipati R Loubani M Lencioni M	2005	Ann Thorac Surg2005，79，6：	1
8	Coronary endarterec- tomy: impact on morbidity and mortality when combined with coro- nary artery bypass surgery 显示文摘	Tiruvoipati R Loubani M Lencioni M	2005	Ann Thorac Surg2005，79，6：	1
9	Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium显示文摘	Hassouna A Loubani M Matata BM	2006	Cardiovasc Res2006，2，：	1
10	Delayed preconditioning of the human myocardium:signal transduction and clinical implications显示文摘	Loubani M Hassouna A Galinanes M	2004	Cardiovasc Res2004，61，3：	1
11	Long-term administration of nicorandil abolishes ischemic and pharmacologic preconditioning of the humen myocardium: role of mitochondrial adenosine triphosphate-dependent potassium channels 显示文摘	Loubani M	2002	J Thorac Cardiovasc Surg2002，124，4：	1
12	Delayed precondition- ing of the human myocardium: signal transduction and clinical implications 显示文摘	Loubani M Hassouna A Galinanes M	2004	Cardiovasc Res2004，61，3：	1
13	Mitochondrial dysfunc- tion as the cause of the failure to precondition the diabetic human myocardium 显示文摘	Hassouna A Loubani M Matata BM	2006	Cardiovase Res2006，69，：	1
14	Safety and efficacy of transplantation of autologous bone marrow into scarred myoeardium for the en hancement of cardiac function in man显示文摘	GALINANES M LOUBANI M DAVIES J	2002	Circulation2002，，：	1
15	Delayed preconditioning of the human myocardium: signal transduction and clinical implications显示文摘	Loubani M Hassouna A Galinanes M	2004	Cardiovasc Res2004，61，3：	1
16	Paclitaxel inhibits natural killer cell binding to target cells by down-regulating adhesion molecule expression显示文摘	Loubani O Hoskin DW	2005	Anticancer Res2005，25，2：	1
17	The effect of deep hypo- thermia on the human pulmonary circulation 显示文摘	Ariyaratnam P Loubani M Cale AR	2014	J Therm Biol2014，40，1：	1
18	Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium显示文摘	Hassouna A Loubani M Matata BM	2006	Cardiovasc Res2006，69，2：	1
19	Autotransplantation of unmanipulated bone marrow into scarred myocardium is safe and enhances cardiac function in humans显示文摘	Galinanes M Loubani M Davies J	2004	Cell Transplant2004，13，1：	1
20	Delayed preconditioning of the human myocardium: signal transduction and clinical implications显示文摘	Loubani M Hassouna A Galinanes M	2004	Cardiovasc Res2004，61，3：	1

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