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| 1 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 2 | Multi-Centre European Experience with Intragastric Balloon in Overweight Populations: 13 Years of Experience显示文摘 | Alfredo Genco Gontrand López-Nava Christian Wahlen Roberta Maselli Massimiliano Cipriano Maria Mara Arenas Sanchez Chantal Jacobs Michele Lorenzo | 2013 | Obesity Surgery2013，，4： | 2 |
| 3 | Heavy metals in sewage sludge amended soils determined by sequential extractions as afunction of incubation time of soils显示文摘 | SANCHEZ M J GARCfA D M LORENZO L F | 2007 | Geoderma2007，，142： | 1 |
| 4 | ETHYI ENE RESPONSE FACTOR1 integrates signals from ethylene and j asmonate pathways in plant defense 显示文摘 | LORENZO O PIQUERAS R SANCHEZ - SERRANO J J | 2003 | Plant Cell2003，15，1： | 1 |
| 5 | The content and distribution of cadmium in soils as influenced by the soil properties显示文摘 | Sanchez Camazano M Sanchez-Martin M J Lorenzo L F | 1994 | Science of Total Environment1994，156，： | 1 |
| 6 | Assessment of erythropoiesis activity during hemodialysis therapy by soluble transferrin receptor levels and ferrokinetic measurements显示文摘 | Lorenzo J D Rodriguez M M Sanchez MS | | 0，，03： | 1 |
| 7 | Depressive symptoms and otherfactors associated with poor sef-rated health in the elderly gender differences显示文摘 | Millan-Calenti JC Sanchez A Lorenzo T | 2012 | Geriat Gerontol Int2012，12，2： | 1 |
| 8 | ETHYI,ENE-RESPONSE-FACTOR 1 integrates signals from ethylene and jasmonate pathways in plant defense显示文摘 | Lorenzo O Piqueras R Sanchez -Serrano J J | 2003 | Plant Ce112003，15，： | 1 |
| 9 | Hydrate formation in gas-dominant systems using a single-pass flowloop显示文摘 | LORENZO M D AMAN Z M SANCHEZ S G | 2014 | Energy & Fuels2014，28，5： | 1 |
| 10 | Evaluation of a greenhouse crop transpiration model with cucumber under high radiation conditions显示文摘 | Medrano E Lorenzo P Sanchez Guerrero M C | 2001 | Acta-Horticulturae2001，559，2： | 1 |
| 11 | Non-glucose carbohydrates in the parenteral nutrition of patients with systemic inflammatory response syndrome 显示文摘 | Lopez Martinez J Sanchez CastiUa M de Juana Velasco P Diaz Abad R Rodriguez Roldan JM Garcia de Lorenzo y Mateos A Del Nogal Saez F | 1999 | Nutricion Hospitalaria1999，14，2： | 1 |
| 12 | ETHYLENE RESPONSE FACTOR1 integrates signals from ethylene and jasmonate pathways in plant defense显示文摘 | Lorenzo O Piqueras R Sanchez S J | 2003 | The Plant Cell2003，15，1： | 1 |
| 13 | Significance of soil properties for content and distribution of cadmium and lead in natural calcareous soils 显示文摘 | Sanchez C Sanchez M Lorenzo L | 1998 | The Science of the Total Environment1998，218，： | 1 |
| 14 | Effect of An- nealing Time on the Self-nucleation Behavior of Semicrystal- line Polymers显示文摘 | Lorenzo A T Amal M L Sanchez J J | 2006 | Journal of Polymer Science Part B:Poly- mer Physics2006，44，12： | 1 |
| 15 | A semantic approach to discovering learning services in grid-based collaborative systems 显示文摘 | Vega-Gorgojo Guillermo Bore Lorenzo Miguel L Goomez- Sanchez Eduardo | 2006 | Future Generation Computer Systems2006，22，6： | 1 |
| 16 | Leach-ing of Cd,Zn,Pb,and Cu in packed and undisturbed columns of soils afected by the spill from a pyrite mine in the south of Spain显示文摘 | M J Sanchez Martin L F Lorenzo M Sanchez Camaza | | 0，，04： | 1 |
| 17 | Effectof modes of public services delivery on the efficiency of localgovernments: A two - stage approach 显示文摘 | C BALLESTEROS I M G SANCHEZ J LORENZO | 2013 | Utilities Policy2013，，2： | 1 |
| 18 | Ethylene response factorl integrates signals from ethylene and jasmonate pathways in plant defense显示文摘 | Lorenzo O Piqueras R Sanchez JJ | 2003 | Plant Ce112003，15，： | 1 |
| 19 | Early and Extended Therapy for Recurrent Hepatitis C after Liver Transplantation显示文摘 | F. García-Pajares C. Almohalla S. Lorenzo Pelayo R. Ruiz Zorrilla P. Pinto C. Ramos G. Sanchez Antolin A.C. Paton | 2012 | Transplantation Proceedings2012，，6： | 1 |
| 20 | Indications and effectiveness of the mammalian target of rapamycin in liver transplantation显示文摘 | Sanchez Antolín G Garcia Pajares F Lorenzo Pelayo S | 2011 | Transplant Proc2011，43，3： | 1 |
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