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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 3 | Selective glucoeorticoid control of Rho kinase isoforms regulate cell-cell interactions 显示文摘 | Rubenstein N M Callahan J A Lo D H | 2007 | Biochem Biophys Res Commun2007，354，2： | 1 |
| 4 | Biomechanical correlations of lesions assocjated with traumatic diseases of the anterjor cruciate ligament:Analysis with MR显示文摘 | Demaria M Barbiera F Lo Casto A | 1996 | Radiol Med Torino1996，91，6： | 1 |
| 5 | Advances in the preparation of magnetic nanoparticles by the microemulsion method显示文摘 | LO' PEZ PE' REZ J A LO' PEZ QUINTELA M A MIRA J | 1997 | J Phys Chem B1997，101，41： | 1 |
| 6 | Microemulsion Dynamics and Reactions in Microemulsions显示文摘 | M A Lo'pez-Quimela C Tojo M C Blanco | 2004 | Current Opinion in Colloid and Interface Science2004，9，34： | 1 |
| 7 | Cystatin C and modification of diet in renal disease (MDRD) estimated glomerular filtration rate dif- fer during normal pregnancy显示文摘 | Larsson A Palm M Hansson LO | 2010 | Acta Obstet Gynecol Scand2010，89，7： | 1 |
| 8 | The science of stroke: mechanisms in search of treatments显示文摘 | Moskowitz M A Lo E H Iadecola C | 2010 | Neuron2010，67，2： | 1 |
| 9 | Defini-tion of relapse risk and role of nonanthracycline drugsfor consolidation in patients with acute promyelocyticleukemia: A joint study of the PETHEMA andG1MEMA cooperative groups 显示文摘 | SANZ M A LO COCO F MARTIN G | 2000 | Blood2000，96，： | 1 |
| 10 | Water storage in the wood and xylem cavitation in 1-year-old twigs of Populus deltoids 显示文摘 | Lo Gullo M A Salleo S | 1992 | Plant Cell and Environment1992，15，4： | 1 |
| 11 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 12 | Propionibacterium acnes and SAPHO syndrome:a case report and literature review显示文摘 | Colina M Lo Monaco A Khodeir M | 2007 | Clin Exp Rheumatol2007，25，3： | 1 |
| 13 | Generation of a new cystatin C-based estimating equation for glomerular filtration rate by use of 7 assays standardized to the international calibrator 显示文摘 | Grubb A Horio M Hansson LO | 2014 | Clin Chem2014，60，7： | 1 |
| 14 | Management of endoscopic retrograde cholangio- pancreatography: related duodenal perforations 显示文摘 | Avgerinos D V Llaguna O H Lo A Y Voli J Leitman I M | 2009 | Surg Endosc2009，23，： | 1 |
| 15 | Current theories on the pathogenesis of infan- tile hemangioma 显示文摘 | Lo K Mihm M Fay A | 2009 | Semin Ophthalmol2009，24，3： | 1 |
| 16 | The recurrent goiter:prevention and management显示文摘 | Cappel ani A Di Vita M Zanghì A Lo Menzo E Caval aro A Alfano G Giuffrida D | | 0，，04： | 1 |
| 17 | Asset allocation and derivatives,quant显示文摘 | Haugh M Lo A | 2001 | Finance2001，1，： | 1 |
| 18 | Vul-canization kinetics of natural rubber-organoclay nanocom-posites显示文摘 | M A Lo'pez-Manchado M Arroyo B Herrero | 2003 | Journal of Applied Polymer Science2003，，89： | 1 |
| 19 | Current theories on the pathogenesis of in- fantile hemangioma 显示文摘 | Lo K Mihm M Fay A | 2009 | Semin Ophthalmol2009，24，3： | 1 |
| 20 | Isolated hydatid diseases of the spleen: CT findings in patients and differential diagnosis显示文摘 | Lo Gasto A Galia M Barbiera F | 2002 | Radiol Med(Torino)2002，104，3： | 1 |
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