|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life显示文摘AIM:To determine the dose-related effects of a novel probiotic combination,I.31,on irritable bowel syndrome(IBS)-related quality of life(IBS-QoL).METHODS:A multicenter,randomized,double-blind,placebo-controlled intervention clinical trial with three parallel arms was designed.A total of 84 patients(53female,31 male;age range 20-70 years)with IBS and diarrhea according to Rome-Ⅲcriteria were randomly allocated to receive one capsule a day for 6 wk containing:(1)I.31 high dose(n=28);(2)I.31 low dose(n=27);and(3)placebo(n=29).At baseline,and 3and 6 wk of treatment,patients filled the IBSQoL,Visceral Sensitivity Index(VSI),and global symptom relief questionnaires.RESULTS:During treatment,IBS-QoL increased in all groups,but this increment was significantly larger in patients treated with I.31 than in those receiving placebo(P=0.008).After 6 wk of treatment,IBS-QoL increased by 18±3 and 22±4 points in the high and the low dose groups,respectively(P=0.041 and P=0.023vs placebo),but only 9±3 in the placebo group.Gutspecific anxiety,as measured with VSI,also showed a significantly greater improvement after 6 wk of treatment in patients treated with probiotics(by 10±2 and14±2 points,high and low dose respectively,P<0.05for both vs 7±1 score increment in placebo).Symptom relief showed no significant changes between groups.No adverse drug reactions were reported following the consumption of probiotic or placebo capsules.CONCLUSION:A new combination of three different probiotic bacteria was superior to placebo in improving IBS-related quality of life in patients with IBS and diarrhea. | Vicente Lorenzo-Zú?iga Elba Llop Cristina Suárez Beatriz álvarez Luis Abreu Jordi Espadaler Jordi Serra | 2014 | World Journal of Gastroenterology2014，20，26： | 13 |
| 2 | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma显示文摘Pancreatic cancer(Pa C) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease. | Esther Llop Pedro E Guerrero AdriàDuran Sílvia Barrabés Anna Massaguer María JoséFerri Maite Albiol-Quer Rafael de Llorens Rosa Peracaula | 2018 | World Journal of Gastroenterology2018，24，24： | 4 |
| 3 | P2X4受体对活化的小胶质细胞的调控作用显示文摘小胶质细胞是中枢神经系统内的免疫细胞,当脑组织出现损伤时,小胶质细胞被激活,对脑组织起到保护作用。在自身免疫性脑脊髓炎模型大鼠和视神经脊髓炎患者体内,均观察到在脊髓炎性病灶及小胶质细胞内,P2X4受体表达上调。本课题组进行在体和离体实验,用LPS活化小胶质细胞,观察P2X4受体在小胶质细胞炎性反应中的作用。膜片钳检测显示,在LPS激活的小胶质细胞内,P2X4受体活性增加。P2X4受体阻断剂可显著降低小胶质细胞的膜皱缩、TNFα的分泌、细胞形态的改变及LPS导致的小胶质细胞死亡。在体研究显示,LPS髓内注射后会诱发炎性反应,迅速导致小胶质细胞丢失;给予P2X4受体阻断剂可显著减少小胶质细胞的丢失,而P2X4受体激活剂则可显著增加小胶质细胞的丢失。海马齿状回的小胶质细胞特别容易被LPS诱导的炎症反应激活。注射LPS后2 h,位于海马齿状回的小胶质细胞即被激活,大约24 h后死亡,P2X4受体阻断剂可减少LPS诱导的小胶质细胞活化和死亡。上述数据提示,P2X4受体对于小胶质细胞的激活和存活有重要的调控作用。 | Vázquez-Villoldo N Domercq M Martín A Llop J Gómez-Vallejo V Matute C | 2014 | 神经损伤与功能重建2014，9，1： | 4 |
| 4 | Estimation of visceral fat is useful for the diagnosis of significant fibrosis in patients with non-alcoholic fatty liver disease显示文摘BACKGROUND Obesity is a risk factor for non-alcoholic fatty liver disease(NAFLD),although obese patients with NAFLD do not always develop significant fibrosis.The distribution of body fat could predict the risk of NAFLD progression.AIM To investigate the role of bioelectrical impedance-estimated visceral fat(VF)in assessing NAFLD severity.METHODS In this cross-sectional study,patients with biopsy-proven NAFLD were prospectively included.All patients underwent anthropometric evaluation,blood tests and bioelectrical impedance analysis.RESULTS Between 2017 and 2020,119 patients were included[66.4%male,56 years(SD 10.7),62.2%obese,61.3%with metabolic syndrome].Sixty of them(50.4%)showed significant fibrosis(≥F2)in liver biopsy.Age,VF and metabolic syndrome were associated with significant fibrosis(61 years vs 52 years,16.4 vs 13.1,73.3%vs 49.2%,respectively;P<0.001 for all).In the multivariate analysis,VF and age were independently associated with significant fibrosis(VF,OR:1.11,95%CI:1.02-1.22,P=0.02;age,OR:1.08,95%CI:1.03-1.12,P<0.01).A model including these variables showed and area under the receiver operating characteristic curve(AUROC)of 0.75,which was not inferior to transient elastography or NAFLD fibrosis score AUROCs.We developed a nomogram including age and VF for assessing significant fibrosis in routine practice.CONCLUSION VF is a surrogate marker of liver fibrosis in patients with NAFLD.Bioelectrical impedance analysis is an inexpensive and simple method that can be combined with age to guide patient referral when other resources may be unavailable. | Marta Hernández-Conde Elba Llop Carlos Fernández Carrillo Beatriz Tormo Javier Abad Luis Rodriguez Christie Perelló Marta López Gomez JoséLuis Martínez-Porras Natalia Fernández Puga Maria Trapero-Marugan Enrique Fraga Carlos Ferre Aracil JoséLuis Calleja Panero | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 5 | Automated determination of aliphatic primary amines in wastewater by simultaneous derivatization and headspace solid-phase micro- extraction followed by gas chromatography-tandem mass spec- trometry 显示文摘 | Llop Anna Pocurull Eva Borrull Francesc | 2010 | Journal of Chromatography A2010，1217，4： | 1 |
| 6 | High levels of multiple antibiotic resistance among 938 Haemophilus influenzae type b meningitis isolates from Cuba (1990-2002)显示文摘 | Tamargo I Fuentes K Llop A | 2003 | J Antimicrob Chemother2003，52，4： | 1 |
| 7 | Prenatal exposure to lead in Spain: cord blood levels and associated factors 显示文摘 | Llop S Aguinagalde X Vioque J | 2011 | Sci Total Environ2011，409，： | 1 |
| 8 | Outpatient treatment of Pseudomonas aeruginosa bronchial colonization with long-term inhaled colistin, tobramycin, or both in adults without cystic fibrosis显示文摘 | Berlana D Llop JM Manresa F | 2011 | Pharmacotherapy2011，31，2： | 1 |
| 9 | A cDNA clone highly expressed in ripe banana fruit shows homology to pectate lyases显示文摘 | Dominguez-Puigianer E Llop I Vendrell M Prat S | 1997 | Plant Physiology1997，114，： | 1 |
| 10 | The importance of clinical factors in parenteral nutrition-associated hypertriglyceridemia显示文摘 | Llop J Sabin P GarauM | 2003 | Clin Nutr2003，22，： | 1 |
| 11 | Chemical modification of jute fibers for the production of green-composites 显示文摘 | Corrales F Vilaseca F Llop M | 2007 | Joumal of Haz- ardous Materials2007，144，3： | 1 |
| 12 | Coastal Chilean populations genetic markers in four locations显示文摘 | Llop E Moreno R | 1998 | Rev Med Chil1998，126，7： | 1 |
| 13 | Chemical Modification of Jute Fibers for the Production of Green-composites显示文摘 | Corrales F Vilaseca F Llop M | 2007 | Journal of Hazardous Materials2007，144，3： | 1 |
| 14 | Chemical modification of jute fibers for the production of green- composites显示文摘 | Corrales F Vilaseca F Llop M | 2007 | Journal of Hazardous Materials2007，144，3： | 1 |
| 15 | Economic impact of alternative water policy scenarios in the Spanish production system : An input - output analysis 显示文摘 | LLOP M | 2008 | Ecological Economics2008，68，12： | 1 |
| 16 | Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children显示文摘 | Casas L Fernández M F Llop S | 2011 | Environment International2011，37，5： | 1 |
| 17 | Development of a highly sensitivic nested-PCR procedure using a single closed tube for detection of Erwinia amylovora in asymptomatic plant material 显示文摘 | Llop P B A Penalver J | 2000 | Applied and Environmental Microbiology2000，66，： | 1 |
| 18 | Develop-ment of a highly sensitive nested-PCR procedure using a single closed tube for detection of Erwinia amylovora in asmptomatic plant material显示文摘 | PABOL LLOP ANNA BONATERRA JAVIER PEALVER | 2000 | Appl Environ Microbio2000，66，5： | 1 |
| 19 | Chemical modification of jute fibers for the production of green-composites显示文摘 | Corrales F Vilaseca F Llop M | 2007 | Journal of Hazardous Materials2007，144，3： | 1 |
| 20 | Variable rate dosing in precision viticulture: Use of electronic devices to improve application efficiency显示文摘 | Llorens J Gil E Llop J | 2010 | Crop Protection2010，29，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员