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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing显示文摘Localized surface plasmon resonance(LSPR)biosensing based on supported metal nanoparticles offers unparalleled possibilities for high-end miniaturization,multiplexing and high-throughput label-free molecular interaction analysis in real time when integrated within an opto-fluidic environment.However,such LSPR-sensing devices typically contain extremely large regions of dielectric materials that are open to molecular adsorption,which must be carefully blocked to avoid compromising the device readings.To address this issue,we made the support essentially invisible to the LSPR by carefully removing the dielectric material overlapping with the localized plasmonic fields through optimized wet-etching.The resulting LSPR substrate,which consists of gold nanodisks centered on narrow SiO2 pillars,exhibits markedly reduced vulnerability to nonspecific substrate adsorption,thus allowing,in an ideal case,the implementation of thicker and more efficient passivation layers.We demonstrate that this approach is effective and fully compatible with state-of-the-art multiplexed real-time biosensing technology and thus represents the ideal substrate design for high-throughput label-free biosensing systems with minimal sample consumption. | Srdjan S Aćimović Hana Šípová Gustav Emilsson Andreas B Dahlin Tomasz J Antosiewicz Mikael Käll | 2017 | Light(Science & Applications)2017，6，1： | 3 |
| 3 | A Method for Quantifying Vulnerability, Applied to the Agricultural System of the YaquiValley, Mexico 显示文摘 | Amy LL David B L Leonard S S | 2003 | Global Environmental Change2003，13，： | 1 |
| 4 | The β-1,3-glucan-binding protein from the crayfish Pacifastacus leniusculus, when reached with a β43 man, induces spreading and degranulation of crayfish granular cells显示文摘 | Barracco M A Duvic B Sǒderhāll K | 1991 | Cell Tissue Res1991，266，： | 1 |
| 5 | Neural mechanism of acupuncture - modulated gastric motility 显示文摘 | Ll Y Q Zhu B Rong P J | 2007 | World J Gastroenterol2007，13，5： | 1 |
| 6 | Deep sequencing of the oral microbiome reveals signatures of periodontal disease显示文摘 | Liu B Failer LL Klitgord N | 2012 | PLoS One2012，7，37： | 1 |
| 7 | β-1,3-glucan-binding protein from plasma of the fresh water crayfishes Astacus astacus and Procamnarus clarkii显示文摘 | Duvic B Sǒderhāll K | | J Crustacean Biology0，13，3： | 1 |
| 8 | Dietary supplementation with At-ractylodes Macrophala Koidz polysaccharides ameliorate metabolic status and improve immune function in early-weaned pigs显示文摘 | Li LL Yin FG Zhang B | 2011 | Livest Sci2011，142，1： | 1 |
| 9 | Homocysteine increases neuronal damage in hippocampal slices receiving oxygen and glucose deprivation显示文摘 | Zamin LL Salbego CG | 2006 | Metab Brain Dis2006，21，： | 1 |
| 10 | Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants显示文摘 | Stoll B J Hansen N Fanaroff AA Wright LL Carlo WA Ehrenkranz RA | 2002 | N Engl J Med2002，347，4： | 1 |
| 11 | Age-related differ?ences in visual perception, a PET study显示文摘 | Levine B Beason-Held LL Purpura KP | 2000 | Neurobiol Aging2000，21，4： | 1 |
| 12 | Differential T cell cytokine receptivity and not signal quality distinguishes IL 6 and IL-10 signaling during Th17 differentiation显示文摘 | Jones LL Alli R Li B | 2016 | J Immu- nol2016，196，7： | 1 |
| 13 | TGF beta1 expression and angiogenesis in colorectal cancer tissue显示文摘 | Xiong B Gong LL Zhang F | 2002 | World J Gastroenterol2002，8，3： | 1 |
| 14 | Orlly bioavailable beta 3-adrenergic receptor agonists as potential therapeutic agents for obesity and type 2diabetes mellitus显示文摘 | Hu B Jennings LL | 2003 | Prog Med Chem2003，41，： | 1 |
| 15 | 查看详情显示文摘 | T(o)r(o)k B Balázsik K Sz(o)ll(o)si G Felf(o)ldi K | | 0，，： | 1 |
| 16 | Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses显示文摘 | Hemmingsen B Christensen LL Wetterslev J | 2012 | Bri Med J2012，344，： | 1 |
| 17 | Homoeysteine increases neuronal damage in hippocampal slices receiving oxygen and glucose deprivation显示文摘 | Tagliari B Zamin LL Salbego CG | 2006 | Metab Brain Dis2006，21，4： | 1 |
| 18 | Vascular biology in implantation and placentation显示文摘 | HUPPERTZ B PEETERS LL | 2005 | Angiogenesis2005，8，2： | 1 |
| 19 | Association of gamma glutamyltransferase, metabolic syndrome and cardiovascular risk 显示文摘 | Martins MC Faleiro LL Afonso B | 2010 | Acta Med Port2010，23，4： | 1 |
| 20 | Artificial and bioartificial support systems for acute and acute-on-chronic liver failure:A systematic review显示文摘 | Kjaergard LL Liu J Als-Nielsen B | | 0，，02： | 1 |
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