|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Up-regulation of hypoxia-inducible factor-1α enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats显示文摘Hyperlipidemia 是在 ischemic 心疾病的发展的一个独立风险因素,它能增加心肌的危险性到 ischemia/reperfusion (I/R ) 损害。Ischemic postconditioning (PostC ) 现在作为新奇策略被表明了处于正常条件对心肌的 I/R 损害利用自然的保护。然而, hyperlipidemic 动物上的 PostC 的效果留下逃犯。PostC 减少心肌的 I/R 损害,这在我们的以前的学习被显示出,并且组织缺氧可诱导的 factor-1 (HIF-1 ) 可以在正常老鼠上在 PostC 的 cardioprotective 机制起一个重要作用。这里,我们测试了 hyperlipidemic 老鼠上的 PostC 的 cardioprotection 与起来调整的 HIF-1 表示被联系的假设。男 Wistar 老鼠用一本高脂肪的食谱被喂 8 个星期,然后随机把组划分了成五:假冒, I/R, dimethyloxalylglycine (DMOG )+ I/R, PostC,和 DMOG + PostC 组织。I/R 损害导致的有害索引包括了梗塞尺寸,血浆肌酸 kinase (CK ) 活动和 caspase-3 活动。,结果与 I/R 组相比证明 PostC 能减少梗塞尺寸,它与血浆 CK 的重要底层一致活动和 caspase-3 活动,和那它在 hyperlipidemic 老鼠增加了 HIF-1 的表示。当 DMOG 在 PostC 前被给起来调整 HIF-1 蛋白质水平时, I/R 损害的度被稀释。在结论,这些数据建议 HIF-1 的起来规定可以是对在 hyperlipidemic 老鼠的 I/R 损害的 PostC 的 cardioprotective 机制之一。 | Xiaoyu Li Huanxin Zhao Ye Wu Suli Zhang Xiaoqin Zhao Yan Zhang Jin Wang Jie Wang Huirong Liu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 9 |
| 2 | Ultra-small platinum nanoparticles segregated by nickle sites for efficient ORR and HER processes显示文摘In the electrochemical process,Pt nanoparticles(NPs)in Pt-based catalysts usually agglomerate due to Oswald ripening or lack of restraint,ultimately resulting in reduction of the active sites and catalytic efficiency.How to uniformly disperse and firmly fix Pt NPs on carbon matrix with suitable particle size for catalysis is still a big challenge.Herein,to prevent the agglomeration and shedding of Pt NPs,Ni species is introduced and are evenly dispersed in the surface of carbon matrix in the form of Ni-N-C active sites(Ni ZIF-NC).The Ni sites can be used to anchor Pt NPs,and then effectively limit the further growth and agglomeration of Pt NPs during the reaction process.Compared with commercial Pt/C catalyst,Pt@Ni ZIF-NC,with ultralow Pt loading(7 wt%)and ideal particle size(2.3 nm),not only increases the active center,but also promotes the catalysis kinetics,greatly improving the ORR and HER catalytic activity.Under acidic conditions,its half-wave potential(0.902 V)is superior to commercial Pt/C(0.861 V),and the mass activity(0.38 A per mg Pt)at 0.9 V is 4.7 times that of Pt/C(0.08 A per mg Pt).Besides,it also shows outstanding HER performance.At 20 and 30 mV,its mass activity is even 2 and 6 times that of Pt/C,respectively.Whether it is under ORR or HER conditions,it still shows excellent durability.These undoubtedly indicate the realization of dual-functional catalysts with low-Pt and high-efficiency properties. | Lvhan Liang Huihui jin Huang Zhou Bingshuai Liu Chenxi Hu Ding Chen Jiawei Zhu Zhe Wang Hai-Wen Li Suli Liu Daping He Shichun Mu | 2022 | Journal of Energy Chemistry2022，31，2： | 2 |
| 3 | Autoantibody against angiotensin AT1 receptor from preeclamptic patients enhances collagen-induced human platelet aggregation显示文摘Hypercoagulability,血小板激活,和 thrombocytopenia 是 preeclampsia 的主要特征,但是他们的负责的内在的分子的机制仍然保持阴暗。最近的研究证明了对血管收缩素 II 类型 1 受体(AT1-AA ) 的自身抗体为 preeclampsia 组成一个新奇风险因素。然而,在血小板激活的 AT1-AA 和在 preeclampsia 的 hypercoagulability 的角色从来没被调查过。在现在的学习,我们决定了 AT1-AA 是否在 vitro 支持血小板聚集,并且把潜在的位于 \O 下面机制。AT1-AA 被连接酶的 immunosorbent 试金检测。在从 preeclamptic 病人净化的免疫球蛋白 G 部分以后,积极 sera 被加到从健康志愿者,血小板聚集和细胞内部的 Ca2+ 孤立的血小板层次被检测。AT1-AA 显著地在 vitro 提高了导致骨胶原的血小板聚集,效果由 AT1 受体对手 losartan 堵住了。另外, AT1-AA 在整个实验增加了并且维持导致骨胶原的 cytosolic 钙集中。我们第一次证明 AT1-AA 显著地在 vitro 通过血管收缩素类型 1 受体激活支持导致骨胶原的血小板聚集,潜在地经由增加的细胞内部的 Ca2+ 集中,作为一个潜在的贡献者支持 AT1-AA 到 preeclampsia 的 hypercoagulable 状态。 | Kehua Bai Ke Wang Xiaoyu Li Jie Wang Jie Zhang LiSong Jin Wang Suli Zhang Wayne Bond Lau Xinliang Ma Huirong Liu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 2 |
| 4 | GC-ECD analysis of S-metolachlor (Dual Gold) in cotton plant and soil in trial field显示文摘 | Pengying Cao Fengmao Liu Suli Wang | 2008 | Environ Monit Assess2008，143，： | 1 |
| 5 | Macrophage polarization is involved in liver fibrosis induced byβ_(1)-adrenoceptor autoantibody显示文摘Accumulating evidence suggests that liver injury can be induced by the over-expression ofβ_(1)-adrenergic receptors(β_(1)-ARs).High titers of autoantibodies specific toβ_(1)-adrenergic receptors(β_(1)-AA)are detected in the sera of heart failure patients,potentially playing agonist-like roles.However,the role ofβ_(1)-AA in liver function has not been characterized.In this study,we collect the sera of primary biliary cholangitis(PBC)patients,a condition which easily develops into liver fibrosis,and analyze the relationship between PBC andβ_(1)-AA.A passive immunization model is established to assess the effect ofβ_(1)-AA on the liver.Subsequently,the effect ofβ_(1)-AA on macrophages is investigated in vitro.Results show that PBC patients have a high titer and ratio ofβ_(1)-AA,compared to controls.Liver injury and fibrosis are induced byβ_(1)-AA.In vitro experiments with ROS probe demonstrate thatβ_(1)-AA induces macrophages to produce ROS and secrete TNFα.These effects can be partially reversed by metoprolol,a blocker forβ_(1)-AR.Results from the transwell and phagocytosis assays show thatβ_(1)-AA promotes macrophage migration and phagocytosis.FCM tests suggest thatβ_(1)-AA induces the alteration of M1 rather than M2 markers in macrophages.Finally,the Annexin V/PI assay indicates that macrophage culture supernatants stimulated byβ_(1)-AA cause hepatocyte apoptosis.Overall,these results suggest thatβ_(1)-AA is involved in PBC.Theβ_(1)-AA-induced activation,phagocytosis and phenotypic modification of macrophages may play an important role in the development of hepatic fibrosis and injury. | Ye Wu Xiongxiong Fan Haicun Yu Jingyi Liu Yanru Duan Suli Zhang Li Yan Yunhui Du Huirong Liu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 1 |
| 6 | Tunable Atomic-Scale Steps and Cavities Break Both Stability and Activity Limits of CoO_(x) Nanosheets to Catalyze Oxygen Evolution显示文摘A highly active interface can enhance the catalytic efficiency of catalysts toward the oxygen evolution reaction(OER).However,accurately tuning their atomic interface configurations of defects with sufficient activity and stability remains a grand challenge.Herein,we report on breaking the activity and stability limits of CoO_(x) nanosheets in the OER process by constructing copious high-energy atomic steps and cavities,in which S or Ce atoms simultaneously replace O or Co atoms from CoO_(x),thus achieving high-energy atomic interface Ce,O-Co_(3)S_(4) nanosheets.By combining in situ characterization and density functional theory calculations,it is shown that the unique orbital coupling between Ce-4f,O(S)-2p,and Co-3d causes it to be closer to the Fermi level,leading to faster charge transfer capability.More importantly,the novel structure breaks the stability limit of cobalt sulfide with planar defects,which gives high catalytic activity and stability in 0.1 M KOH solutions,better than commercial RuO_(2) and IrO_(2) noble metal catalysts.As expected,Ce,O-Co_(3)S_(4) possesses much better turnover frequency activity(0.064 s^(-1))at an overpotential of 300 mV,which is ~7 times larger than that of Ce-CoO_(x)(0.009 s^(-1)).Our work presents a new perspective of designing catalysts with atomically dispersed orbital electronic coupling defects toward efficient OER electrocatalysis. | Min Yu Xueqin Mu Weitao Meng Ziyue Chen Yu Tong Yu Ge Shiyuan Pang Shengjie Li Suli Liu Shichun Mu | 2023 | Renewables2023，1，4： | 1 |
| 7 | The organic ligands coordinated long after glow phosphor 显示文摘 | WU Suli ZHANG Shufen LIU Yu | 2007 | Maters Lett2007，61，： | 1 |
| 8 | The organic ligands coordinated long afterglow phosphor显示文摘 | WU Suli ZHANG Shufen LIU Yu | 2007 | Materials Letters2007，61，1415： | 1 |
| 9 | The organic ligands coordinated long afterglow phosphor 显示文摘 | WU Suli ZHANG Shufen LIU Yu | 2007 | Mater Lett2007，61，： | 1 |
| 10 | The organic ligands coordinated long afterglow phosphor显示文摘 | WU Suli ZHANG Shufen LIU Yu | | 0，，14： | 1 |
| 11 | Decreased dynamin-related protein 1-related mitophagy induces myocardial apoptosis in the aging heart显示文摘An increase in cardiomyocyte apoptosis is the main contributor to the observed high morbidity of cardiac disease during aging.Mitochondria play important roles in cardiac apoptosis,and dynamin-related protein 1(Drp1)is the critical factor that participates in mitochondrial fission and induces mitophagy to maintain mitochondria quality.However,whether Drp1 is involved in the increase of apoptosis in aging heart remains unclear.The purpose of this study was to determine whether Drp1 participates in inducing the apoptosis through regulating mitophagy in aging myocardium.To explore the effect of mitophagy and apoptosis in aging heart,we detected the expression of COX IV and the co-localization of COX IV and LC3 II,which reflect mitophagy,and measured adenosine triphosphate and reactive oxygen species contents,which reflect mitochondrial injury.Cell apoptosis was detected by measuring the activity of caspase-3 and the expression of cleaved caspase-3 and further confirmed by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling(TUNEL)assay.The results showed an increase in apoptosis and a decrease in mitophagy in aging cardiomyocytes,and apoptosis was ameliorated after the induction of mitophagy by carbonyl cyanide m-chlorophenyl hydrazone(a mitophagy activator)in D-galactose(D-gal)-induced senescence H9c2 cells.To clarify the role of Drp1 in apoptosis,we knocked down Drp1 by transfecting si-Drp1,or overexpressed Drp1 in senescent cells,and then detected mitophagy,mitochondrial injury,and apoptosis.The data showed that downregulated Drp1 induces mitochondrial damage and apoptosis.In addition,to explore the regulatory relationship between Drp1 and phosphatase and tensin homologue(PTEN)-induced putative kinase 1(PINK1)/Parkin-mediated mitophagy,we detected the expressions of PINK1 and Parkin after the overexpression of Drp1 in the D-gal group cells and found that Drp1-mediated mitophagy inhibited the PINK1/Parkin pathway in senescent cells.Our results demonstrated that insufficient Drp1 induces cardiomyocyte apoptosis by inhibiting mitophagy,and Drp1 affects the PINK1/Parkin pathway of mitophagy in the aging heart. | Xin Wei Ye Wu Wen Wang Suli Zhang Dan Liu Huirong Liu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 1 |
| 12 | Expression of 15?hydroxyprostaglandin dehydrogenase and cyclooxygenase?2in non?small cell lung cancer: Correlations with angiogenesis and prognosis显示文摘 | Ying Li Suli Li Dan Sun Linlin Song Xinmin Liu | 2014 | Oncology Letters2014，，4： | 1 |
| 13 | Dissipation and residueof 2,4-disooctyl ester in wheat and soil显示文摘 | Liu Congyun Li Li Wang Suli | 2012 | Environ MonitAssess2012，184，42： | 1 |
| 14 | GC-ECD analysis of S-metolachlor (Dual Gold) in cotton plant and soil in trial field显示文摘 | CAO Pengying LIU Fengmao WANG Suli | 2008 | Environ Monit Assess2008，143，13： | 1 |
| 15 | High Fe^(LS)(C)electrochemical activity of an iron hexacyanoferrate cathode boosts superior sodium ion storage显示文摘Sodium iron hexacyanoferrate(FeHCF)is one of the most promising cathode materials for sodium-ion batteries(SIBs)due to its low cost theoretical capacity.However,the low electrochemical activity of Fe^(LS)(C)in FeHCF drags down its practical capacity and potential plateau.Herein,FeHCF with high Fe^(LS)(C)electrochemical activity(C-FeHCF)is synthesized via a facile citric acid-assisted solvothermal method.As the cathode of SIBs,C-FeHCF shows superior cycling stability(ca.87.3%capacity retention for 1000 cycles at 10 C)and outstanding rate performance(ca.68.5%capacity retention at 50 C).Importantly,the contribution of Fe^(LS)(C)to the whole capacity was quantitatively analyzed via combining dQ/dV and discharge curve for the first time,and the index reaches 44.53%for C-FeHCF,close to the theoretical value.In-situ X-ray diffraction proves the structure stability of C-FeHCF during charge-discharge process,ensuring its superior cycling performance.Furthermore,the application feasibility of the C-FeHCF cathode in quasi-solid SIBs is also evaluated.The quasi-solid SIBs with the C-FeHCF cathode exhibit excellent electrochemical performance,delivering an initial discharge capacity of 106.5 mAh g^(−1) at 5 C and high capacity retention of 89.8%over 1200 cycles.This work opens new insights into the design and development of advanced cathode materials for SIBs and the beyond. | Junhong Guo Fan Feng Shiqiang Zhao Zhenhai Shi Rui Wang Meng Yang Fangfang Chen Suli Chen Zi-Feng Ma Tianxi Liu | 2023 | Carbon Energy2023，5，5： | 1 |
| 16 | The inhibitory effect of BKca channels induced by autoantibodies against angiotensin Ⅱ type 1 receptor is independent of ATIR显示文摘 | Peng Wang Suli Zhang Jie Ren Li Yan Lina Bai Li Wang Pengli Wang Jingwei Bian Xiaochen Yin Huirong Liu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 1 |
| 17 | Human ether-à-go-go-related gene expression is essential for cisplatinto induce apoptosis in human gastric cancer显示文摘 | Riping Zhang Pei Tian Qiang Chi Jizhou Wang Yongwei Wang Lingyu Sun Yang Liu Suli Tian Qifan Zhang | 2012 | Oncology Reports2012，，2： | 1 |
| 18 | The organic ligands coordinated long afterglow phosphor显示文摘 | SULI WU SHUFEN ZHANG YU LIU | 2007 | Materials Letters2007，，61： | 1 |
| 19 | Gi-protein-coupledβ_(1)-adrenergic receptor:re-understanding the selectivity ofβ_(1)-adrenergic receptor to G protein显示文摘β_(1)-adrenergic receptor(β_(1)-AR),a member in the family of G-protein-coupled receptors,is a transmembrane receptor of great significance in the heart.Physiologically,catecholamines activateβ_(1)-AR to initiate a positive chronotropic,inotropic,and dromotropic change.It is believed thatβ_(1)-AR couples to Gs protein and transmits the signal through second messenger cAMP.However,increasing research shows thatβ_(1)-AR can also bind with Gi protein in addition to Gs.Whenβ_(1)-AR-Gi is biasedly activated,cardioprotective effects are introduced by the activated cGMP-protein kinase G(PKG)pathway and the transactivation of epidermal growth factor receptor(EGFR)pathway.The discovery ofβ_(1)-AR-Gi signaling makes us reconsider the selectivity of G protein with regard toβ_(1)-AR,which also provides new ideas for the treatment of heart diseases.This review summarizes the discovery ofβ_(1)-AR-Gi pathway,including the evidence that supportsβ_(1)-AR’s capability to couple Gi,details of the transduction process and functions of theβ_(1)-AR-Gi signaling pathway. | Hao Chen Suli Zhang Ruiqi Hou Huirong Liu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 0 |
| 20 | Single-atom Fe Embedded Co_(3)S_(4) for Efficient Electrocatalytic Oxygen Evolution Reaction显示文摘Constructing atomically dispersed active sites with densely exposed and dispersed double metal-Sx catalytic sites for favorable OER catalytic activity remains rare and challenging.Herein,we design and construct a Fe_(1)S_(x)@Co_(3)S_(4) electrocatalyst with Fe single atoms epitaxially confined in Co_(3)S_(4) nanosheets for catalyzing the sluggish alkaline oxygen evolution reaction(OER).Consequently,in ultralow concentration alkaline solutions(0.1 mol/L KOH),such a catalyst is highly active and robust for OER with low overpotentials of 300 and 333 mV at current densities of 10 and 30 mA/cm^(2),respectively,accompanying long-term stability without significant degradation even for 350 h.In addition,Fe_(1)S_(x)@Co_(3)S_(4) shows a turnover frequency(TOF)value of 0.18 s−1,nearly three times that of Co_(3)S_(4)(0.07 s−1),suggesting the higher atomic utilization of Fe single atoms.Mössbauer and in-situ Raman spectra confirm that the OER activity of Fe_(1)S_(x)@Co_(3)S_(4) origins from a thin catalytic layer of Co(Fe)OOH that interacts with trace-level Fe species in the electrolyte,creating dynamically stable active sites.Combined with experimental characterizations,it suggests that the most active S-coordinated dual-metal site configurations are 2S-bridged(Fe-Co)S4,in which Co-S and Fe-S moieties are shared with two S atoms,which can strongly regulate the adsorption energy of reaction intermediates,accelerating the OER reaction kinetics. | QI Yuxue LI Tingting HU Yajie XIANG Jiahong SHAO Wenqian CHEN Wenhua MU Xueqin LIU Suli CHEN Changyun YU Min MU Shichun | 2022 | Chemical Research in Chinese Universities2022，38，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员